Results 101 to 110 of about 1,553,593 (211)

Brain immune interactions and air pollution: Macrophage inhibitory factor (MIF), Prion cellular protein (PrPC), Interleukin-6 (IL-6), Interleukin 1 receptor antagonist (IL-1Ra), and Interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe versus low air pollution.

Frontiers in Neuroscience, 2013
Mexico City Metropolitan Area children chronically exposed to high concentrations of air pollutants exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, innate and adaptive immune responses along with accumulation of ...
Lilian eCalderon-Garciduenas, Janet V Cross, Maricela eFranco-Lira, Mariana eAragon-Flores, Michael eKavanaugh, Ricardo eTorres-Jardon, Chih-kai eChao, Charles eThompson, Jing eChang, Hongtu eZhu, Amedeo eD'Angiulli   +10 more
doaj   +1 more source

The presence of valine at residue 129 in human prion protein accelerates amyloid formation [PDF]

, 2005
The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies.
Tahiri-Alaoui, Abdessamad, Gill, A, Shaw, Michael, Shaw, M, Baskakov, I, Breydo, L, James, W, Tahiri-Alaoui, A, Disterer, Petra, Gill, Andrew, Baskakov, Ilia, Breydo, Leonid, Disterer, P, James, William   +13 more
core   +1 more source

Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy.

PLoS Pathogens, 2017
Aggregation of misfolded proteins or peptides is a common feature of neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, prion and other diseases.
Elizaveta Katorcha, Natallia Makarava, Young Jin Lee, Iris Lindberg, Mervyn J Monteiro, Gabor G Kovacs, Ilia V Baskakov   +6 more
doaj   +1 more source

PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction : [Langfassung]

, 2004
The cellular prion protein (PrPc) resides in lipid rafts, yet the type of raft and the physiological function of PrPc are unclear. We show here that cross-linking of PrPc with specific antibodies leads to 1) PrPc capping in Jurkat and human peripheral ...
Guse, Andreas H., Hannbeck von Hanwehr, Sylvia, Wiechers, Marianne F., Plattner, Helmut, Legler, Daniel F., Langhorst, Matthias F., Stürmer, Claudia   +6 more
core   +1 more source

Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression

Frontiers in Pharmacology, 2018
Naïve depression patients show alterations in serotonin transporter (SERT) and serotonin 2A (5HT2A) receptor clustering in peripheral lymphocytes, and these alterations have been proposed as a biomarker of therapeutic efficacy in major depression ...
Raquel Romay-Tallon, Erin Kulhawy, Kyle J. Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M. Olivares, Lisa E. Kalynchuk, Hector J. Caruncho   +7 more
doaj   +1 more source

Analysis of the protein expression to investigate the physiological funktion of the cellular prion protein (PrPc)

, 2012
Die genaue physiologische Funktion des zellulären Prionproteins (PrPc) ist bislang nicht abschließend geklärt. Einerseits gibt es zahlreiche Hinweise in vitro und auch in vivo, die auf eine neuroprotektive ...
Weiß, Eva Annabelle
core   +1 more source

Characterization of PrpC from Bacillus subtilis , a Member of the PPM Phosphatase Family

, 2000
We cloned the yloO gene and purified a His-tagged form of its product, the putative protein phosphatase YloO, which we now designate PrpC.
G. Boël, E. Madec, D. Delattre, M. Obuchowski, A. Iwanicki, S. J. Séror, D. Foulger   +6 more
core   +1 more source

Immunological role of cellular prion protein (PrPC) during cytomegaloviral infection

, 2022
Aims: Human cytomegalovirus (HCMV) infection is the most common congenital viral infection and the leading cause of lasting perinatal brain damage, with the inflammatory response being the primary cause of pathogenic manifestations. Accordingly, it has been shown that anti-inflammatory drugs can reduce abnormalities in newborn mice infected with mouse ...
Karner, Dubravka, Kveštak, Daria, Kučan Brlić, Paola, Cokarić Brdovčak, Maja, Lisnić, Berislav, Brizić, Ilija, Juranić Lisnić, Vanda, Golemac, Mijo, Tomac, Jelena, Hasan, Milena, Jonjić, Stipan, Lenac Roviš, Tihana   +11 more
openaire   +3 more sources

Implications of cellular prion protein in tumor biology

Frontiers in Oncology
Prion proteins (PrP) are primarily known for their role in neurodegenerative conditions like Creutzfeldt-Jakob Disease, where the misfolded, pathogenic isoform PrPSc propagates by using the normal cellular prion protein, PrPc, as a template, leading to ...
Ahmed Damra
doaj   +1 more source

Role of PrPC glycosylation in health and disease [PDF]

, 2013
Glycosylation is the most abundant post-translational modification of proteins and has the ability to change the physical properties of the protein and its cell biology. The cellular prion protein (PrPC) is a membrane bound host glycoprotein present in a
Iremonger, Kayleigh
core   +2 more sources