Results 81 to 90 of about 1,553,593 (211)

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition

Frontiers in Cell and Developmental Biology, 2014
Knowledge of phenotypic changes the cellular prion protein (PrPC) contributes to may provide novel avenues for understanding its function. Here we consider data from functional knockout/down studies and protein-protein interaction analyses from the ...
Mohadeseh eMehrabian, Sepehr eEhsani, Gerold eSchmitt-Ulms   +2 more
doaj   +1 more source

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, Volume 99, Issue 5, Page 1303-1314, May 2026.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Pharmacological Agents Targeting the Cellular Prion Protein

Pathogens, 2018
Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain ...
Maria Letizia Barreca, Nunzio Iraci, Silvia Biggi, Violetta Cecchetti, Emiliano Biasini   +4 more
doaj   +1 more source

Characteristic distribution and molecular properties of normal cellular prion protein in human endocrine and exocrine tissues

Scientific Reports, 2022
Prion disease is an infectious and fatal neurodegenerative disease. Human prion disease autopsy studies have revealed abnormal prion protein (PrPSc) deposits in the central nervous system and systemic organs.
Sachiko Koyama, Hideko Noguchi, Kaoru Yagita, Hideomi Hamasaki, Masahiro Shijo, Motoi Yoshimura, Kohei Inoshita, Naokazu Sasagasako, Hiroyuki Honda   +8 more
doaj   +1 more source

Advanced Non‐Enzymatic Electrochemical Sensor Materials for Alzheimer's Disease Biomarkers

Analysis &Sensing, Volume 6, Issue 3, May 2026.
This review summarizes advances in materials‐driven, non‐enzymatic electrochemical biosensors for early Alzheimer's diagnosis via biofluid analysis. Amyloid‐β and hyperphosphorylated Tau are highlighted alongside sensor performance metrics, including sensitivity and selectivity.
Wei‐Ting Ting, Md Younus Ali, Claire Gage, Margaret Fahnestock, M. Firoz Mian, Matiar M. R. Howlader   +5 more
wiley   +1 more source

Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells [PDF]

Differentiation, 2011
The mammalian cellular prion protein (PrP(C)) is a highly conserved glycoprotein that may undergo conversion into a conformationally altered isoform (scrapie prion protein or PrP(Sc)), widely believed to be the pathogenic agent of transmissible spongiform encephalopathies (TSEs).
Oscar A, Peralta, William R, Huckle, Willard H, Eyestone   +2 more
openaire   +2 more sources

Variably Protease‐Sensitive Prionopathy: Two New Cases With Motor Neuron‐Dementia Syndrome

Annals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 827-833, April 2026.
ABSTRACT We describe two patients with variably protease‐sensitive prionopathy (VPSPr) who developed progressive upper motor neuron symptoms, insomnia, behavioral and cognitive decline, compatible with primary lateral sclerosis associated with frontotemporal dementia (FTD).
María Elena Erro, María Victoria Zelaya, Hasier Eraña, Javier Sánchez Ruiz de Gordoa, Fermín García‐Amigot, Anika Simonovska‐Serra, María Cristina Caballero, Isidre Ferrer, Ellen Gelpi, Ivonne Jericó, Joaquín Castilla   +10 more
wiley   +1 more source

Physiological role of the cellular prion protein (PrPc): Protein profiling study in two cell culture systems

, 2008
The physiological role of the cellular prion protein (PrPc) is still not fully understood. Current evidence strongly suggests that PrPc overexpression in different cell lines sensitizes cells to apoptotic stimuli through a p53 dependent pathway.
Groschup, Martin H., Armstrong, V.W., Zerr, Inga, Zerr, I., Wrede, Arne, Balkema-Buschmann, Anne, Wrede, A., Ramljak, Sanja, Asif, Abdul R., Bodemer, Walter, Buschman, Anne, Schulz-Schaeffer, Walter J., Armstrong, Victor William, Schulz-Schaeffer, W., Asif, A.R., Ramljak, S.   +15 more
core   +1 more source

Cellular prion protein (PrPC) protects neuronal cells from the effect of huntingtin aggregation [PDF]

Journal of Cell Science, 2007
The effect of normal cellular prion protein (PrPC) on abnormal protein aggregation was examined by transfecting huntingtin fragments (Htt) into SN56 neuronal-derived cells depleted of PrPC by RNA interference. PrPC depletion caused an increase in both the number of cells containing granules and the number of apoptotic cells.
Kyung-Jin, Lee, Antony, Panzera, David, Rogawski, Lois E, Greene, Evan, Eisenberg   +4 more
openaire   +2 more sources

Iron-Restricted Diet Affects Brain Ferritin Levels, Dopamine Metabolism and Cellular Prion Protein in a Region-Specific Manner

Frontiers in Molecular Neuroscience, 2017
Iron is an essential micronutrient for several physiological functions, including the regulation of dopaminergic neurotransmission. On the other hand, both iron, and dopamine can affect the folding and aggregation of proteins related with ...
Jessica M. V. Pino, Marcio H. M. da Luz, Hanna K. M. Antunes, Hanna K. M. Antunes, Sara Q. de Campos Giampá, Vilma R. Martins, Kil S. Lee   +6 more
doaj   +1 more source