Results 121 to 130 of about 69,500 (311)

Differentiation of Plant and Animal‐Derived Cholesterol Using irm‐13C NMR and IRMS

Magnetic Resonance in Chemistry, EarlyView.
Determining and certifying the origin of ingredients, starting materials, and excipients used in manufactured goods like cosmetics and medicines can be difficult. In this report, we describe a robust approach for identifying the origin of cholesterol, a component of myriad consumer products using irm‐13C NMR and IRMS to differentiate plant versus ...
Anika M. Singh, Subir Chakraborty, Remington X. Poulin, R. Thomas Williamson   +3 more
wiley   +1 more source

Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease

, 2010
Hyperphosphorylation of the microtubule-associated protein tau is a significant determinant in AD (Alzheimer's disease), where it is associated with disrupted axonal transport and probably causes synaptic dysfunction.
Perry, V. Hugh, O'Connor, Vincent, Asuni, Ayodeji A.   +2 more
core   +1 more source

SERPINA3/SerpinA3n role in prion diseases [PDF]

, 2021
Prion diseases are a family of rare and fatal neurodegenerative disorders, characterized by the accumulation of abnormally folded prion protein. Previous data suggested that SERPINA3/SerpinA3n might be involved in the pathogenesis and the progression of ...
Zattoni, Marco
core  

Neuroprotective Effects of RNS60 in TDP‐43 Pathology‐Associated Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Introduction TDP‐43 pathology is broadly observed in the cerebral cortex of patients with amyotrophic lateral sclerosis (ALS). RNS60, an experimental treatment for acute ischemic stroke and ALS, enhanced mitochondrial biogenesis and function in other preclinical models.
Danny R. Vesevick, Supurna Ghosh, Andreas Kalmes, P. Hande Ozdinler, Mukesh Gautam   +4 more
wiley   +1 more source

Single-cell transcriptomics unveils molecular signatures of neuronal vulnerability in a mouse model of prion disease that overlap with Alzheimer’s disease

Nature Communications
Understanding why certain neurons are more sensitive to dysfunction and death caused by misfolded proteins could provide therapeutically relevant insights into neurodegenerative disorders.
Jessy A. Slota, Lise Lamoureux, Kathy L. Frost, Babu V. Sajesh, Stephanie A. Booth   +4 more
doaj   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Swine influenza A replicon particle and live attenuated influenza virus vaccines induce differential systemic and mucosal antibody and T cell responses

Frontiers in Veterinary Science
Influenza A virus (IAV) in swine is a significant economic concern, and there is a critical need to improve vaccine efficacy. Commercial and experimental vaccine platforms are effective against homologous infection but may not reliably provide protection
Meghan Wymore Brand, Bryan S. Kaplan, Carine K. Souza, Jayne E. Wiarda, J. Brian Kimble, Bailey Arruda, Daniel R. Perez, Amy L. Baker   +7 more
doaj   +1 more source

Silent Prions and Covert Prion Transmission

PLOS Pathogens, 2015
Prions are infectious agents with zoonotic potential that cause progressive neurodegenerative diseases, known as the transmissible spongiform encephalopathies (TSEs), in animals and humans. Prion disease can be initiated by a spontaneous event, handed down within families from generation to generation through genetic inheritance, or transmitted between
openaire   +4 more sources

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Genetic assessment of apolipoprotein E polymorphism and PRNP genotypes in rapidly progressive dementias in Pakistan

Prion
Rapidly progressive dementias (RPDs) are a type of fatal dementias that cause rapid progression of neuronal dysfunction. This study aimed to assess the prevalence of APOE genotypes (ε2, ε3, ε4) and PRNP mutations (E200K, M129V) in the general population ...
Urwah Rasheed, Minahil Khalid, Aneeqa Noor, Umar Saeed, Rizwan Uppal, Saima Zafar   +5 more
doaj   +1 more source