Results 141 to 150 of about 69,500 (311)

Studies of the transmissibility of the agent of bovine spongiform encephalopathy to the domestic chicken

, 2011
Background: Transmission of the prion disease bovine spongiform encephalopathy (BSE) occurred accidentally to cattle and several other mammalian species via feed supplemented with meat and bone meal contaminated with infected bovine tissue.
Stack Michael J, Robert B Green, Paul R Webb, Simmons, M.M., Timm Konold, Spencer, Y.I., Moore Jo, Marion M Simmons, Ian Dexter, Moore, J., Michael Dawson, Jo Moore, Chaplin, M.J., Webb, P.R., Dexter, I., Wells Gerald AH, Austin, A.R., Dawson, M., Austin Anthony R, Gerald AH Wells, Michael J Stack, Anthony R Austin, Wells, G.A.H, Green Robert B, Langeveld, J.P.M., Ian W Blamire, Stack, M.J., Melanie J Chaplin, Simmons, M., Konold Timm, Dawson Michael, Spencer Yvonne I, Hawkins, S.A.C., Konold, T., Simmons Marion M, Chaplin Melanie J, Hawkins Stephen AC, Dexter Ian, Blamire Ian W, Langeveld Jan PM, Jan PM Langeveld, Webb, P.R.I., Yvonne I Spencer, Green, R.B., Blamire, I.W., Webb Paul R, Stephen AC Hawkins   +46 more
core   +1 more source

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Prion-dependent proteome remodeling in response to environmental stress is modulated by prion variant and genetic background

, 2019
A number of fungal proteins are capable of adopting multiple alternative, self-perpetuating prion conformations. These prion variants are associated with functional alterations of the prion-forming protein and thus the generation of new, heritable traits
Dale M. Cameron (6371915), Shaima Kammoonah (6371912), Thibault Mayor (234478), Christina Kelly (6371909), Ben Allwein (6371906)   +4 more
core   +1 more source

Overlap of nonbreeding wandering albatrosses with fisheries and implications for colony‐specific population trajectories at South Georgia

Conservation Biology, EarlyView.
Abstract Bycatch in fisheries is one of the most serious threats to pelagic seabirds, causing major population declines. Mitigation measures can reduce bycatch substantially, but many fisheries fail to apply best practices, and seabird mortality remains high.
V. Warwick‐Evans, E. J. Pearmain, R. A. Phillips   +2 more
wiley   +1 more source

Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding

Prion
Mutations in superoxide dismutase 1 (SOD1) cause paralysis in familial amyotrophic lateral sclerosis and promote its misfolding into neurotoxic aggregates.
Guilian Xu, Amanda Lopez, Selma Brkic, Susan Fromholt, Paramita Chakrabarty, David R. Borchelt   +5 more
doaj   +1 more source

Prions and prion diseases [PDF]

The FEBS Journal, 2007
openaire   +2 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Synthesis and structural characterization of a mimetic membrane-anchored prion protein

, 2006
During pathogenesis of transmissible spongiform encephalopathies (TSEs) an abnormal form (PrPSc) of the host encoded prion protein (PrPC) accumulates in insoluble fibrils and plaques. The two forms of PrP appear to have identical covalent structures, but
Hicks, M R, David H. Crout, Crout, D H, Teresa J. T. Pinheiro, Ian D. Sylvester, Andrew C. Gill, Imanpreet K. Bath, Atvinder K. Rullay, Gill, A C, Bath, I K, Pinheiro, T J T, Matthew R. Hicks, Sylvester, I D, Rullay, A K   +13 more
core   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Prion seeding activity in DNA extractions: implications for laboratory biosafety

Prion
Infectious prions (PrPSc) are largely resistant to proteolytic digestion, including proteinase K (PK) digestion. While nucleic acid extracts are generally considered non-infectious from a classical microbiology context (i.e.
Sarah C. Gresch, Tamara Morrill, Maddy Ellis-Cramer, Maria Arifin, Lexi E. Frank, Jason C. Bartz, Marc D. Schwabenlander, Tiffany M. Wolf, Gordon B. Mitchell, Jiewen Guan, Peter A. Larsen   +10 more
doaj   +1 more source