Results 31 to 40 of about 97,942 (322)
Canine detection of chronic wasting disease (CWD) in laboratory and field settings
Prion, 2023 Chronic wasting disease (CWD) is a fatal transmissible spongiform encephalopathy that affects both free-ranging and farmed cervid species, including mule deer, white-tailed deer, and elk (Odocoileus hemionus, Odocoileus virginianus, and Cervus canadensis)
Amritha Mallikarjun +11 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 1984 Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
openaire +3 more sources
Prion, 2023 Gerstmann–Sträussler–Scheinker disease with a Pro-to-Leu substitution at codon 105 in the prion protein gene (GSS-P105L) is a rare variant of human genetic prion disease.
Honami Kawai +3 more
doaj +1 more source
Expression of the cellular prion protein by mast cells in the human carotid body
Prion, 2023 Prion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known.
Gregory D. Sweetland +4 more
doaj +1 more source
Prion, 2023 Among the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now a rising concern in wildlife within Europe, after the detection of the first case in Norway in 2016, in a wild reindeer and until June 2022 a ...
Jorge C. Pereira +21 more
doaj +1 more source
Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS
Nature, 2013 Summary Algorithms designed to identify canonical yeast prions predict that ~250 human proteins, including several RNA-binding proteins associated with neurodegenerative disease, harbor a distinctive prion-like domain (PrLD) enriched in uncharged polar ...
Hong-Joo Kim +36 more
semanticscholar +1 more source
Prion, 2022 Chronic wasting disease (CWD) is a fatal encephalopathy affecting North American cervids. Certain alleles in a host’s prion protein gene are responsible for reduced susceptibility to CWD.
Alberto F. Fameli +4 more
doaj +1 more source
Cellular Prion Protein Mediates Impairment of Synaptic Plasticity by Amyloid-β Oligomers
Nature, 2009 A pathological hallmark of Alzheimer’s disease is an accumulation of insoluble plaque containing the amyloid-β peptide of 40–42 amino acid residues. Prefibrillar, soluble oligomers of amyloid-β have been recognized to be early and key intermediates in ...
J. Laurén +4 more
semanticscholar +1 more source
What is the evidence that tau pathology spreads through prion-like propagation?
Acta Neuropathologica Communications, 2017 Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas.
A. Mudher +10 more
semanticscholar +1 more source
Prion-Like Propagation of Protein Misfolding and Aggregation in Amyotrophic Lateral Sclerosis
Frontiers in Molecular Neuroscience, 2019 The discovery that prion protein can misfold into a pathological conformation that encodes structural information capable of both propagation and inducing severe neuropathology has revolutionized our understanding of neurodegenerative disease.
Luke McAlary +3 more
semanticscholar +1 more source