Results 21 to 30 of about 49,492 (243)
A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis
Nature Communications, 2020 Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy +10 more
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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence
Scientific Reports, 2021 Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53/p21WAF1/CIP1
Ruchi Kumari +7 more
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The Journal of Infectious Diseases, 2002 The “protein only” hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain, and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in that they are transmissible, not only ...
C, Weissmann +4 more
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Structural insights into how augmin augments the mitotic spindle
Nature Communications, 2023 Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al.
Szymon W. Manka
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Genetic Risk Factors of Creutzfeldt-Jakob Disease in the Population of Newborns in Slovakia
Pathogens, 2021 The most frequent human prion disease is Creutzfeldt–Jakob disease (CJD). It occurs as sporadic (sCJD), genetic (gCJD), iatrogenic (iCJD) form and as variant CJD.
Dana Kosorinova +4 more
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A New Cell Model for Investigating Prion Strain Selection and Adaptation
Viruses, 2019 Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes.
Alexandra Philiastides +5 more
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Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro
Scientific Reports, 2022 Prion diseases are characterized by the cellular prion protein, PrPC, misfolding and aggregating into the infectious prion protein, PrPSc, which leads to neurodegeneration and death.
Arielle J. D. Hay +4 more
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Genetic risk factors for Creutzfeldt-Jakob disease
Neurobiology of Disease, 2020 Prion diseases are a group of fatal neurodegenerative disorders of mammals that share a central role for prion protein (PrP, gene PRNP) in their pathogenesis.
Emma Jones, Simon Mead
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A multiplexed, paired-pooled droplet digital PCR assay for detection of SARS-CoV-2 in saliva
Scientific Reports, 2023 In response to the SARS-CoV-2 pandemic, we developed a multiplexed, paired-pool droplet digital PCR (MP4) screening assay. Key features of our assay are the use of minimally processed saliva, 8-sample paired pools, and reverse-transcription droplet ...
Kaitlyn Wagner +26 more
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Proceedings of the National Academy of Sciences, 1984 Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
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