Gene-Edited Cell Models to Study Chronic Wasting Disease
Viruses, 2022 Prion diseases are fatal infectious neurodegenerative disorders affecting both humans and animals. They are caused by the misfolded isoform of the cellular prion protein (PrPC), PrPSc, and currently no options exist to prevent or cure prion diseases ...
Simrika Thapa +5 more
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A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis
Nature Communications, 2020 Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive dementia. No clinical blood tests are available for diagnosis. The authors identified three miRNAs in whole-blood that are downregulated in sCJD patients, and discriminate sCJD from ...
Penny J. Norsworthy +10 more
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Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence
Scientific Reports, 2021 Cellular senescence is a stable cell cycle arrest that normal cells undergo after a finite number of divisions, in response to a variety of intrinsic and extrinsic stimuli. Although senescence is largely established and maintained by the p53/p21WAF1/CIP1
Ruchi Kumari +7 more
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Prion protein self-peptides modulate prion interactions and conversion [PDF]
, 2009 Background: Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrPC) into the scrapie associated isoform (PrPSc), are poorly understood.
Bossers, A. +12 more
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Structural insights into how augmin augments the mitotic spindle
Nature Communications, 2023 Cell division critically requires amplification of microtubules (MTs) in the bipolar mitotic spindle. This relies on the filamentous augmin complex that enables MT branching. Studies by Gabel et al., Zupa et al. and Travis et al.
Szymon W. Manka
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Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc). [PDF]
, 2013 Prion diseases, also known as transmissible spongiform encephalopathies, are a group of fatal neurodegenerative diseases that include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in humans.
Jeremy C. Simpson (29225) +31 more
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Genetic Risk Factors of Creutzfeldt-Jakob Disease in the Population of Newborns in Slovakia
Pathogens, 2021 The most frequent human prion disease is Creutzfeldt–Jakob disease (CJD). It occurs as sporadic (sCJD), genetic (gCJD), iatrogenic (iCJD) form and as variant CJD.
Dana Kosorinova +4 more
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A New Cell Model for Investigating Prion Strain Selection and Adaptation
Viruses, 2019 Prion diseases are fatal neurodegenerative diseases that affect humans and animals. Prion strains, conformational variants of misfolded prion proteins, are associated with distinct clinical and pathological phenotypes.
Alexandra Philiastides +5 more
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Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro
Scientific Reports, 2022 Prion diseases are characterized by the cellular prion protein, PrPC, misfolding and aggregating into the infectious prion protein, PrPSc, which leads to neurodegeneration and death.
Arielle J. D. Hay +4 more
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Genetic risk factors for Creutzfeldt-Jakob disease
Neurobiology of Disease, 2020 Prion diseases are a group of fatal neurodegenerative disorders of mammals that share a central role for prion protein (PrP, gene PRNP) in their pathogenesis.
Emma Jones, Simon Mead
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