Results 141 to 150 of about 42,402 (225)

A fixed brain seeded amplification assay to complement neuropathological prion disease diagnosis. [PDF]

J Neuropathol Exp Neurol
Lewis V, Ellett L, Lei E, Stehmann C, Birchall I, Senesi M, McLean C, Collins SJ.   +7 more
europepmc   +1 more source

Association of recurrence patterns and outcome with HR and HER2 status in patients with resected brain metastases from breast cancer

International Journal of Cancer, Volume 159, Issue 2, Page 440-449, 15 July 2026.
What's new? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller, Sophie Katzendobler, Frederic Thiele, Anna Riesberg, Patrick N. Harter, Frederick Klauschen, Rachel Wuerstlein, Stephan Schoenecker, Montserrat Pazos Escudero, Robert Forbrig, Niklas Thon, Florian Ringel, Michael Weller, Emilie Le Rhun, Veit M. Stoecklein   +14 more
wiley   +1 more source

FMRP‐Mediated Proteasome Regulation: A Novel Mechanism in ALS Pathology

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Schematic model of TDP‐43/TNKS‐mediated proteasome regulation in WT, FMRP‐depleted, and TDP‐43A315T‐Tg ALS neurons. In WT neurons, cytoplasmic TDP‐43 partially sequesters TNKS, maintaining balanced PI31 ribosylation and proteasome activity. FMRP depletion promotes nuclear translocation of TDP‐43, enhances TNKS/PI31 interaction, and increases axonal ...
Pritha Majumder, Asmar Ahsan, Pitchapa Bubphachat, Khadiza Akter, Jeffrey K. Huang, Chi‐Chen Sarah Huang   +5 more
wiley   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain. [PDF]

Animal Model Exp Med
Wang D, Sun Z, Wen P, Zhao M, He Y, Gou F, Wang J, Fan Q, Li X, Ma T, Wang X, Li W, Chen S, Zhao D, Yang L.   +14 more
europepmc   +1 more source

Mechanistic Insights Into Metal Binding in the Aggregation Pathway of an Immunoglobulin Light Chain Protein

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Cardiac antibody light chain (AL) amyloidosis is characterized by the deposition of light chain (LC) variable domain (VL) protein in the heart. Transition metals such as copper and zinc have been suggested to enhance the toxicity of circulating soluble LCs. We show here how divalent metal ions influence the aggregation behavior of the patient‐derived λ‐
Tejaswini Pradhan, Riddhiman Sarkar, Joshua Leonhard‐Preu, Adrian F. Schnell, Nadine Schwierz, Bernd Reif   +5 more
wiley   +1 more source

Refined Transgenic Mouse Models Which Recapitulate the Natural Features of Chronic Wasting Disease With Rapid Prion Disease Onsets. [PDF]

J Infect Dis
DeFranco JP, Kim S, Atkinson ZN, Crowell J, Lei S, Bian J, Telling GC.   +6 more
europepmc   +1 more source

'Prion' Diseases

Journal of the Royal College of Physicians of London, 1994
openaire   +2 more sources

Knockout of P2Y12 receptor facilitates neuronal envelopment by reactive microglia and accelerates prion disease. [PDF]

J Neuroinflammation
Makarava N, Safadi T, Bocharova O, Mychko O, Pandit NP, Molesworth K, Eyo UB, Baskakov IV.   +7 more
europepmc   +1 more source

Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease. [PDF]

Sci Adv
Yan R, Zhang Y, Zhang J, Zhang X, Han Y, Wang M, Wang D, Huang S, Liu W, Shi Q, Dong X, Zou WQ, Li Z, Ma J.   +13 more
europepmc   +1 more source

Dysregulated microRNAs in blood correlate with central nervous system neuropathology of prion disease. [PDF]

Vet Res
Pérez-Lázaro S, Martín-Burriel I, Cozzuto L, Ponomarenko J, Badiola JJ, Bolea R, Toivonen JM.   +6 more
europepmc   +1 more source