Results 31 to 40 of about 82,850 (254)

Short incubation periods of atypical H-type BSE in cattle with EK211 and KK211 prion protein genotypes after intracranial inoculation

Frontiers in Veterinary Science, 2023
In 2006, a case of atypical H-type BSE (H-BSE) was found to be associated with a germline mutation in the PRNP gene that resulted in a lysine substitution for glutamic acid at codon 211 (E211K). The E211K amino acid substitution in cattle is analogous to
Eric D. Cassmann, Alexis J. Frese, Alexis J. Frese, Alexis J. Frese, Kelsey A. Becker, Kelsey A. Becker, Justin J. Greenlee   +6 more
doaj   +1 more source

Genetic Factors Contributing to the Susceptibility of Development of Prion Diseases [PDF]

, 2017
This paper won an honorable mention writing flag award in the research category. Claire Culbertson, writing for Katherine Bruner’s BIO 325L class, “Lab Experience in Genetics”.Bruner, KatherineUndergraduate ...
Culbertson, Claire
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Genetic aspects of human prion diseases

Frontiers in Neurology, 2022
Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby, Brian S. Appleby, Shashirekha Shetty, Shashirekha Shetty, Mohamed Elkasaby   +4 more
doaj   +1 more source

Molecular Dynamics Studies on 3D Structures of the Hydrophobic Region PrP(109-136) [PDF]

, 2013
Prion diseases caused by the conversion from a soluble normal cellular prion protein into insoluble abnormally folded infectious prions, are invariably fatal and highly infectious degenerative diseases that affect a wide variety of mammalian species. The
Zhang, Jiapu, Zhang, Yuanli
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Swine influenza A replicon particle and live attenuated influenza virus vaccines induce differential systemic and mucosal antibody and T cell responses

Frontiers in Veterinary Science
Influenza A virus (IAV) in swine is a significant economic concern, and there is a critical need to improve vaccine efficacy. Commercial and experimental vaccine platforms are effective against homologous infection but may not reliably provide protection
Meghan Wymore Brand, Bryan S. Kaplan, Carine K. Souza, Jayne E. Wiarda, J. Brian Kimble, Bailey Arruda, Daniel R. Perez, Amy L. Baker   +7 more
doaj   +1 more source

Evaluation of Antemortem Diagnostic Techniques in Goats Naturally Infected With Scrapie

Frontiers in Veterinary Science, 2020
Scrapie is a naturally occurring transmissible spongiform encephalopathy (TSE) that affects sheep and goats. Sheep and goats can be infected with scrapie as lambs or kids via contact with the placenta or placental fluids, or from ingestion of prions shed
Najiba Mammadova, M. Heather West Greenlee, S. Jo Moore, Soyoun Hwang, Aaron D. Lehmkuhl, Eric M. Nicholson, Justin J. Greenlee   +6 more
doaj   +1 more source

Impact of maternal antibodies and weaning stress on the replication and transmission of human H3N2 influenza A in piglets

Journal of Virology
Human seasonal H3N2 influenza A viruses (IAV) are repeatedly transmitted to swine. Modern indoor swine production facilitates close contact between human employees and pigs in their care during certain husbandry events, like weaning, that may increase ...
Giovana Ciacci Zanella, Matias I. Cardenas, Carl R. Hutter, Celeste A. Snyder, Meghan Wymore Brand, Bailey Arruda, Daniel R. Perez, Tavis K. Anderson, Daniela S. Rajão, Amy L. Baker   +9 more
doaj   +1 more source

IVIG Delays Onset in a Mouse Model of Gerstmann-Sträussler-Scheinker Disease [PDF]

, 2019
Our previous studies showed that intravenous immunoglobulin (IVIG) contained anti-Aβ autoantibodies that might be able to treat Alzheimer's disease (AD).
Dodel, Richard, Du, Eileen, Du, Yansheng, Farlow, Martin R., Gu, Huiying, Kirchhein, Yvonne, Liu, Junyi, Mastrianni, James A., Peng, Hongjun, Zhao, Gang, Zhu, Timothy   +10 more
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A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody

Scientific Reports, 2022
There is an urgent need to develop disease-modifying therapies to treat neurodegenerative diseases which pose increasing challenges to global healthcare systems.
Madeleine Reilly, Iryna Benilova, Azadeh Khalili-Shirazi, Christian Schmidt, Parvin Ahmed, Daniel Yip, Parmjit S. Jat, John Collinge   +7 more
doaj   +1 more source

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]

, 2006
The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Andréoletti, Banks, Baron, Baylis, Bieschke, Brown, Buschmann, Catherine Viguié, Chantal Imbs, Ecroyd, Elsen, Green, Hunter, Le Dur, Mohammed Moudjou, Morel, Moudjou, Nicole Picard-Hagen, Pierre-Louis Toutain, Rezaei, Safar, Toutain, Véronique Gayrard, Weller, Wong   +24 more
core   +3 more sources