Results 1 to 10 of about 78,455 (315)
Genome-wide association study of behavioural and psychiatric features in human prion disease. [PDF]
, 2015 Prion diseases are rare neurodegenerative conditions causing highly variable clinical syndromes, which often include prominent neuropsychiatric symptoms.
Carswell, C +9 more
core +3 more sources
Potential Therapeutic Use of Stem Cells for Prion Diseases [PDF]
Cells, 2023 Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed +2 more
doaj +2 more sources
Genetic aspects of human prion diseases [PDF]
Frontiers in Neurology, 2022 Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby +4 more
doaj +2 more sources
Loss of Homeostatic Microglia Signature in Prion Diseases [PDF]
Cells, 2022 Prion diseases are neurodegenerative diseases that affect humans and animals. They are always fatal and, to date, no treatment exists. The hallmark of prion disease pathophysiology is the misfolding of an endogenous protein, the cellular prion protein ...
Yue Wang +7 more
doaj +2 more sources
Human prion diseases and the prion protein – what is the current state of knowledge? [PDF]
Translational Neuroscience, 2023 Prion diseases and the prion protein are only partially understood so far in many aspects. This explains the continued research on this topic, calling for an overview on the current state of knowledge.
Nafe Reinhold +2 more
doaj +2 more sources
New implications for prion diseases therapy and prophylaxis [PDF]
Frontiers in Molecular NeurosciencePrion diseases are rare, fatal, progressive neurodegenerative disorders that affect both animal and human. Human prion diseases mainly present as Creutzfeldt-Jakob disease (CJD).
Fangzhou Liu, Wenqi Lü, Ling Liu
doaj +2 more sources
An overview of animal prion diseases [PDF]
Virology Journal, 2011 Prion diseases are transmissible neurodegenerative conditions affecting human and a wide range of animal species. The pathogenesis of prion diseases is associated with the accumulation of aggregates of misfolded conformers of host-encoded cellular prion ...
Imran Muhammad, Mahmood Saqib
doaj +2 more sources
The Risk of Transmission of Genetic Prion Diseases is Greater Than 50. [PDF]
Eur J NeurolKortazar-Zubizarreta I +5 more
europepmc +3 more sources
Role of Biomarkers for the Diagnosis of Prion Diseases: A Narrative Review. [PDF]
Medicina (Kaunas), 2022 Altuna M +3 more
europepmc +3 more sources
Scientific Reports, 2022 Transgenic mice over-expressing human PRNP or murine Prnp transgenes on a mouse prion protein knockout background have made key contributions to the understanding of human prion diseases and have provided the basis for many of the fundamental advances in
Graham S. Jackson +5 more
doaj +1 more source