Results 141 to 150 of about 78,455 (315)

Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease [PDF]

open access: hybrid, 2021
Julie-Myrtille Bourgognon   +8 more
openalex   +1 more source

Japan Brain Bank Net (JBBN)

open access: yesPsychiatry and Clinical Neurosciences, EarlyView.
Autopsies have long been performed to determine the cause of death in the medical field. In fact, autopsies have significantly contributed to our understanding of neurological and psychiatric disorders. Patients and their families who wish to donate bodies for autopsy may have various expectations, such as contributing to the development of treatments ...
Masaki Takao
wiley   +1 more source

Increased Borrelia burgdorferi Seroprevalence in Nova Scotia—Prevalence and Distribution 10 Years Later

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Lyme disease (LD), a tick‐borne infection, is endemic in Nova Scotia. One decade ago, the seropositivity rate to Borrelia burgdorferi was 2/1855 (0.14%). In the current study, using residual sera representing ages 10–64 years, we demonstrate an increase in seroprevalence, to 25/1872 (1.60%), with the highest seroprevalence in the western area ...
Carrie Phillips   +10 more
wiley   +1 more source

Electrostatics in the Stability and Misfolding of the Prion Protein: Salt Bridges, Self-Energy, and Solvation

open access: yes, 2010
Using a recently developed mesoscopic theory of protein dielectrics, we have calculated the salt bridge energies, total residue electrostatic potential energies, and transfer energies into a low dielectric amyloid-like phase for 12 species and mutants of
Cashman, Neil R.   +2 more
core   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer   +2 more
wiley   +1 more source

Serpin Signatures in Prion and Alzheimer’s Diseases [PDF]

open access: hybrid, 2022
Marco Zattoni   +14 more
openalex   +1 more source

Doppel as an early‐stage biomarker promoting EMT and dissemination in ovarian cancers

open access: yesInternational Journal of Cancer, Volume 158, Issue 6, Page 1755-1768, 15 March 2026.
What's new? Existing biomarkers for ovarian cancer (OC) lack the sensitivity and specificity needed to consistently distinguish the malignancy from non‐ovarian influences and other cancers. Here, the authors explored the ability of the prion‐like protein Doppel, normally found in the male testes, to detect OC.
Zulfikar Azam   +18 more
wiley   +1 more source

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