Results 151 to 160 of about 45,606 (277)
‘I Don't Want to Kill Any More Mice’: Taboo and Silence in PhD Education
Higher Education Quarterly, Volume 80, Issue 3, July 2026.ABSTRACT Improving the experience and well‐being of doctoral students requires a deep and nuanced understanding of their challenges. Traditionally, researchers have used reactive methods, such as surveys and interviews, to address these issues. However, some topics may be difficult to capture through these approaches, particularly those that are ...
Saule Bekova, Ivan Smirnov
wiley +1 more source
Folding and fibril formation of prions [PDF]
Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
core
HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1283-1288, June 2026.ABSTRACT The Clinical Assessment Scale in Autoimmune Encephalitis (CASE) tracks disease severity in autoimmune encephalitis (AE), but no threshold for significant change exists. We aimed to determine the minimally clinically important difference (MCID) for CASE.
Yihui Goh +8 more
wiley +1 more source
RATIONAL DISCOVERY OF MULTI-TARGET AGENTS FOR PRION DISEASES
, 2011 Prion diseases are prototypical conformational diseases. From a medicinal chemistry point of view, all conformational diseases are ‘black boxes’ because the three-dimensional structure and the mechanistic properties of the target are not fully available.
G. Legname +4 more
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Efeito da proteina celular do Prion (PrPc) na atividade da enzima superóxido dismutase (SOD) em células vasculares sob estresse oxidativo [PDF]
, 2008 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em FarmáciaA proteína celular do prion (PrPC) é expressa em vários tipos celulares, especialmente em neurônios. Sua função fisiológica
Soprana, Hélen Zocche
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A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Proteína prion celular (PrPc) altera a suscetibilidade ao etanol através da modulação do sistema dopaminérgico [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em FarmacologiaO consumo de drogas com potencial aditivo, como o etanol, induz alterações sinápticas profundas na via mesocorticolímbica ...
Rial, Daniel
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Advanced Healthcare Materials, Volume 15, Issue 21, 5 June 2026.Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Prions and Public Health Office (PPHO) [PDF]
PPHO monitors human prion diseases in the US and coordinates programs related to these and other selected neurological diseases and illnesses of unknown causes such as Nodding syndrome and Kawasaki syndrome.
core +2 more sources