Results 151 to 160 of about 2,165,687 (231)

FIS1 dependent peripheral fission exacerbates mitochondrial fragmentation and dysfunction in prion diseases. [PDF]

Front Neurosci
Gou F, Li Z, Li J, Yang D, Zhao M, Wang D, Wen P, Sun Z, Wang J, Fan Q, Dai Y, Zhao D, Yang L.   +12 more
europepmc   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

Theory and simulations of delayed stochastic and deterministic models of prion diseases. [PDF]

J Math Biol
Boregowda G, Sharif O, Gutierrez Iii D, Simmons A, Pujo-Menjouet L, Oraby T, Lindstrom MR.   +6 more
europepmc   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases. [PDF]

Acta Neuropathol Commun
Zhang X, Zhang J, Zhang Y, Wang D, Liu G, Wang M, Li C, Shi Q, Dong X, Yuan C, Li W, Ma J.   +11 more
europepmc   +1 more source

The ESCRT Pathway's Role in Prion Diseases and Beyond. [PDF]

J Neurosci, 2023
Taha HB.
europepmc   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

The Risk of Transmission of Genetic Prion Diseases is Greater Than 50. [PDF]

Eur J Neurol
Kortazar-Zubizarreta I, Manero-Azua A, Eraña H, Aguire U, Castilla J, Perez de Nanclares G.   +5 more
europepmc   +1 more source

Modeling localized deer removal strategies for managing chronic wasting disease

The Journal of Wildlife Management, Volume 90, Issue 7, September 2026.
We used an agent‐based model developed for chronic wasting disease (CWD) in Midwestern white‐tailed deer to assess localized deer removal strategies and how local conditions affect management outcomes. Parcel‐based and ring culling were most effective at reducing CWD prevalence and persistence, and transmission was always greater at greater deer ...
Noelle E. Thompson, Daniel J. O'Brien, Daniel P. Walsh, Chad M. Stewart, Earl G. Krom, Gary J. Roloff   +5 more
wiley   +1 more source

Transmission Ratio Distortion in Genetic Prion Diseases: Clarifying Methodological Considerations. [PDF]

Eur J Neurol
Kortazar-Zubizarreta I, Manero-Azua A, Eraña H, Castilla J, Perez de Nanclares G.   +4 more
europepmc   +1 more source