Results 141 to 150 of about 2,165,687 (231)

Folding and fibril formation of prions [PDF]

Prions diseases are a group of fatal neurodegenerative disorders called the transmissible spongiform encephalopathies (TSEs), which include bovine spongiform encephalopathy in cattle, scrapie in sheep and Creutzfeldt-Jakob disease (CJD) in humans ...
Gierusz, Leszek A.
core  

An Integrated Analysis of Manganese Metabolism‐Related Genes and Their Association With Biomarkers, Immune Infiltration, and Clinical Subtypes in Alzheimer's Disease

Genes, Brain and Behavior, Volume 25, Issue 5, October 2026.
This study investigates the role of manganese metabolism in Alzheimer's disease (AD) pathogenesis. Using integrated bioinformatics and machine learning, four core manganese‐related diagnostic genes (TSPO, PTBP1, GLO1, ACACB) were identified, showing high diagnostic accuracy. The analysis also revealed significant immune microenvironment alterations and
Shengnan Shu, Jiahao Hu, Shanshan Hu, Yefeng Yao   +3 more
wiley   +1 more source

The Role of the Simulation in Supporting Newly Graduated Nurses in Their First 5 Months of Working Transition: Findings From a Mixed‐Method Study

Journal of Clinical Nursing, Volume 35, Issue 10, Page 4210-4220, October 2026.
ABSTRACT Aims To understand the role of simulation in ensuring the development of the competencies expected by newly graduated register nurses (NGRNs) from the work initiation up to 5 months of transition. Methods Mixed‐method study design. A longitudinal phase employing the Nurse Competence Scale (NCS, from 0 to 100, excellent) to assess the perceived
Maura Mesaglio, Sara Dentice, Luca Grassetti, Illarj Achil, Anna Bernardinis, Davide Caruzzo, Anna Inserra, Irene Mansutti, Elisa Mattiussi, Sandra Menegoz, Tommaso Piani, Elena Vanzo, Stefania Chiappinotto, Alvisa Palese   +13 more
wiley   +1 more source

Neurofluid Biomarker Sensors: Integrated Design Strategies From Molecular Recognition to Precision Neurological Diagnosis

Advanced Sensor Research, Volume 5, Issue 9, September 2026.
This review focuses on the principles and signal mechanisms of four types of neurofluid biomarker sensors (electrochemical, optical, mechanical, and multimodal), summarizes the detection strategies for biomarkers such as ions, neurotransmitters, metabolites, and inflammatory proteins and their applications in the diagnosis and treatment of neurological
Ting Li, Guoying Pan, Yuheng Wang, Xin Zou, Hui Yang   +4 more
wiley   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, Volume 13, Issue 51, 14 September 2026.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Aggregate, Volume 7, Issue 9, September 2026.
All‐D peptides that bind monomeric α‐synuclein shift the aggregation equilibrium, dismantle pathogenic fibrils, and suppress seeding activity in vitro and in cells. In a Parkinson's disease mouse model, treatment delays disease progression and extends survival, supporting direct aggregate disassembly as a disease‐modifying therapeutic strategy for ...
Sara Reithofer, Marc Sevenich, Madita Vollmer, Dila Kurtul, Laura Müller, Pelin Özdüzenciler, Laurin Gerhards, Kira Allmeroth, Mathias Wendt, Fahimeh Charbgoo, Sarah Schemmert, Marcel Naumann, Karolina Korostov, Gina Hartmann, Lothar Gremer, Gültekin Tamgüney, Dieter Willbold, Antje Willuweit   +17 more
wiley   +1 more source

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

Cell Biology International, Volume 50, Issue 9, September 2026.
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley   +1 more source

Performance of Alzheimer Disease Plasma Biomarkers in Patients With Prion Diseases. [PDF]

Neurology
Coysh T, Laban R, Veleva E, Heslegrave AJ, Darwent L, Holm-Mercer L, Mok TH, Hart MS, Lunn MP, Keshavan A, Schott JM, Jaunmuktane Z, Brandner S, Gonzalez-Ortiz F, Blennow K, Zetterberg H, Collinge J, Mead S.   +17 more
europepmc   +1 more source

Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
DPMSCs‐derived exosomal PSMD1 stimulates M2 polarization through the JAK2/STAT3 pathway. DPMSCs‐derived exosomal PSMD1 indirectly acts on NE‐4C cells. DPMSCs‐derived exosomal PSMD1 ameliorates SCI in a mouse model. ABSTRACT Background Exosomes derived from mesenchymal stem cells (MSCs) and their cargo contribute to the protective properties of MSCs in ...
Xiaohui Xing, Yuan Hao, Guanghui Zhang, Xiaoyang Xing, Hongfei Jia, Chenlong Liu, Xin Wang, Tao Li, Xueyuan Li, Yilei Xiao   +9 more
wiley   +1 more source