Results 121 to 130 of about 50,704 (271)
Neuropathology, Volume 46, Issue 1, February 2026.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease (MND) characterized by progressive degeneration of both upper and lower motor neurons, along with skeletal muscles innervated by them. The identification of key molecules involved in disease pathology remains crucial for ALS, as no curative treatment is currently available ...
Paloma Martínez‐Alesón +3 more
wiley +1 more source
Transcriptional outputs and condensates – formation and function
New Phytologist, Volume 249, Issue 3, Page 1145-1154, February 2026.Summary The dynamic spatiotemporal organization of macromolecules is key to the proper function of the cell, allowing the exquisite regulation of diverse processes from gene expression to enzymatic function. The formation of biomolecular condensates via phase separation (PS) acts as a general mechanism for selectively concentrating proteins, nucleic ...
Stephanie Hutin +4 more
wiley +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani +12 more
wiley +1 more source
A cold water, ultrasonically activated stream efficiently removes proteins and prion-associated amyloid from surgical stainless steel [PDF]
, 2020 T.J. Secker +5 more
openalex +1 more source
Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo [PDF]
, 2023 Erik Gomez‐Cardona +4 more
openalex +1 more source
Marginal Stability of the YB1 Cold‐Shock Domain in Cells Enables Binding of Multiple Nucleic Acids
Advanced Science, Volume 13, Issue 1, 5 January 2026.This study suggests that the marginal stability of the YB1 Cold‐Shock Domain (CSDex) allows for a balance between multifunctionality and conformational changes under physiological conditions. This balance is driven by the dynamic equilibrium between the unfolded ensemble (UE) and the native ensemble (NE) of CSDex (PDB:6LMR).
Puja Shrestha +4 more
wiley +1 more source
Prion Protein Devoid of the Octapeptide Repeat Region Restores Susceptibility to Scrapie in PrP Knockout Mice [PDF]
, 2000 Eckhard Flechsig +8 more
openalex +1 more source
The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid
Advanced Science, Volume 13, Issue 4, 19 January 2026.Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz +12 more
wiley +1 more source
Amyloid properties of the yeast cell wall protein Toh1 and its interaction with prion proteins Rnq1 and Sup35 [PDF]
, 2018 Aleksandra Sergeeva +6 more
openalex +1 more source