Results 261 to 270 of about 5,604,422 (355)

Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation

Acta Crystallographica Section D, Volume 81, Issue 7, Page 357-379, July 2025.
SFPQ and NONO are DBHS‐family proteins that are essential for transcriptional regulation and the assembly of paraspeckles, which are subnuclear structures built on the long noncoding RNA NEAT1. Through SAXS, SANS and XL‐MS analyses, we reveal that the disordered regions of SFPQ surrounding its DBHS domain enable flexible interactions and that the full ...
Heidar J. Koning, Valerie Lai, Ashish Sethi, Shatabdi Chakraborty, Ching-Seng Ang, Archa H. Fox, Anthony P. Duff, Andrew E. Whitten, Andrew C. Marshall, Charles S. Bond   +9 more
wiley   +1 more source

Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector. [PDF]

Pathogens
Zhang J, Wang M, Wang D, Zhang X, Ma Y, Pardon E, Steyaert J, Abskharon R, Wang F, Ma J.   +9 more
europepmc   +1 more source

Arg177 and Asp159 from dog prion protein slow liquid-liquid phase separation and inhibit amyloid formation of human prion protein. [PDF]

J Biol Chem, 2023
Li XN, Gao Y, Li Y, Yin JX, Yi CW, Yuan HY, Huang JJ, Wang LQ, Chen J, Liang Y.   +9 more
europepmc   +1 more source

Intracellular mechanisms mediating the neuronal death and astrogliosis induced by the prion protein fragment 106–126 [PDF]

, 2000
Stefano Thellung, Tullio Florio, Alessandro Corsaro, Sara Arena, Massimo Merlino, Mario Salmona, Fabrizio Tagliavini, Orso Bugiani, Gianluigi Forloni, Gennaro Schettini   +9 more
openalex   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis. [PDF]

World J Gastrointest Surg
Shin DW, Cho YA, Moon SH, Kim TH, Park JW, Lee JW, Choe JY, Kim MJ, Kim SE.   +8 more
europepmc   +1 more source

Prion protein genes and prion diseases: studies in transgenic mice [PDF]

, 2000
Glenn C. Telling
openalex   +1 more source

Cortical ribbon sign: Initial sign of Creutzfeldt–Jakob disease

Journal of General and Family Medicine, Volume 26, Issue 4, Page 372-374, July 2025.
Shiori Nakamichi, Ryohei Ono, Michihiro Kudo, Shigeto Horiuchi, Izumi Kitagawa   +4 more
wiley   +1 more source

Regulation of physiological and pathological condensates by molecular chaperones

The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree, Valentina Secco, Flonia Levy‐Adam, Amal Younis, Serena Carra, Reut Shalgi   +5 more
wiley   +1 more source

Tau oligomers impair memory and synaptic plasticity through the cellular prion protein. [PDF]

Acta Neuropathol Commun
Balducci C, Orsini F, Cerovic M, Beeg M, Rocutto B, Dacomo L, Masone A, Busani E, Raimondi I, Lavigna G, Chen PT, Leva S, Colombo L, Zucchelli C, Musco G, Kanaan NM, Gobbi M, Chiesa R, Fioriti L, Forloni G.   +19 more
europepmc   +1 more source