Results 271 to 280 of about 97,377 (307)

Hereditary prion protein amyloidoses

Clinics in Laboratory Medicine, 2003
Prion protein (PrP) amyloid accumulation is the pathologic hallmark of some inherited prion diseases such as Gerstmann-Sträussler-Scheinker disease (GSS) and PrP cerebral amyloid angiopathy (PrP-CAA). In GSS, parenchymal amyloidosis may coexist with spongiform degeneration or neurofibrillary tangles, whereas in PrP-CAA, vascular amyloid coexists with ...
Bernardino, Ghetti, Fabrizio, Tagliavini, M, Takao, Orso, Bugiani, Pedro, Piccardo   +4 more
openaire   +2 more sources

Prion Protein Functions and Dysfunction in Prion Diseases

Current Medicinal Chemistry, 2009
Prion diseases are zoonotic infectious diseases caused by infectious particles, termed prions. Main component of prions is presumably a misfolded, partially protease-resistant conformer (PrP(Sc)) of a normal cell surface protein, the cellular prion protein (PrP(C)), whose anti-oxidative role is presumed by studies using prion protein (PrP)-knockout ...
Akikazu, Sakudo, Kazuyoshi, Ikuta
openaire   +2 more sources

Prion protein amplification techniques

2018
Protein amplification techniques exploit the ability of PrPTSE to induce a conformational change in prion protein (PrP) in a continuous fashion, so that the small amount of PrPTSE found in tissues and biologic fluids in prion diseases can be amplified to a point where they are detectable by conventional laboratory techniques.
Alison J E, Green, Gianluigi, Zanusso
openaire   +2 more sources

Prion Protein Disease and Neuropathology of Prion Disease

Neuroimaging Clinics of North America, 2008
Human prion diseases, in common with other neurodegenerative diseases, may be sporadic or inherited and are characterized by the accumulation of cellular proteins accompanied by neuronal death and synaptic loss. Prion diseases are, however, unique in being transmissible.
openaire   +2 more sources

Prion Protein

Nihon rinsho. Japanese journal of clinical medicine, 2012
Naomi, Hachiya, Kiyotoshi, Kaneko
openaire   +3 more sources

Alternative Prion Proteins

The FASEB Journal, 2012
openaire   +2 more sources

Prion-like transmission of protein aggregates in neurodegenerative diseases

Nature Reviews Molecular Cell Biology, 2010
Patrik Brundin, Ronald Melki, Ron Kopito
exaly  

Prion protein

AfCS-Nature Molecule Pages, 2009
Rafael Linden, Vilma Martins, Marco Prado   +2 more
openaire   +1 more source

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

Lancet, The, 2000
Claudio Soto, Pierre Aucouturier, Thomas M Wisniewski   +2 more
exaly  

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Nature, 2012
Julie A Moreno, Helois Radford, Diego Peretti   +2 more
exaly