First report of novel single-nucleotide polymorphisms and genetic characteristics in the open reading frame of the prion protein gene (PRNP) in bats [PDF]
Frontiers in Veterinary ScienceBackgroundPrion diseases are fatal neurodegenerative disorders capable of causing transmissible spongiform encephalopathies (TSEs) and have been reported in humans and several animal species.
Doan-Phuong-Anh Tran +7 more
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Integrated multi-omics elucidates PRNP knockdown-mediated chemosensitization to gemcitabine in pancreatic ductal adenocarcinoma [PDF]
Frontiers in ImmunologyIntroductionPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with an extremely poor prognosis. Gemcitabine (GEM), the standard first-line chemotherapeutic agent for PDAC, often fails due to the development of drug resistance ...
Bing Qi +6 more
doaj +2 more sources
Novel polymorphisms and functional characterization of the prion protein gene in sparrows (Passer montanus) [PDF]
Frontiers in Veterinary ScienceBackgroundMisfolding of the prion protein (PrP) into an aberrant conformation causes prion diseases in several mammalian species; however, no prion infections have been documented in birds so far.
Chau-Giang Truong +5 more
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Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep [PDF]
Open Veterinary JournalBackground: Scrapie is a deadly neurodegenerative transmissible spongiform encephalopathy (TSE) that affects sheep and goats. TSEs are a consequence of polymorphisms of the prion protein gene PRNP, which result in misfolded prion proteins.
Arif Wicaksono +5 more
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PRNP is a pan-cancer prognostic and immunity-related to EMT in colorectal cancer
Frontiers in Cell and Developmental BiologyBackgroundPrion protein gene (PRNP) is widely expressed in a variety of tissues. Although the roles of PRNP in several cancers have been investigated, no pan-cancer analysis has revealed its relationship with tumorigenesis and immunity ...
Du Yao
exaly +3 more sources
PrP gene polymorphism and its influence on some productive traits of sheep breeds reared in Bulgaria [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 The rapid dissemination of scrapie over the past few decades led to development of a specific eradica-tion programme, based on the polymorphisms within the prion protein gene (PRNP).
T. Koynarski
doaj +1 more source
Prion protein expression regulates embryonic stem cell pluripotency and differentiation. [PDF]
PLoS ONE, 2011 Cellular prion protein (PRNP) is a glycoprotein involved in the pathogenesis of transmissible spongiform encephalopathies (TSEs). Although the physiological function of PRNP is largely unknown, its key role in prion infection has been extensively ...
Alberto Miranda +3 more
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Prion, 2022 Creutzfeldt-Jakob disease (CJD) is usually sporadic, but 10–15% of cases are caused by autosomal-dominant pathogenic variants in the prion protein gene (PRNP). A few PRNP variants show low penetrance.
Ilaria Gandoglia +5 more
doaj +1 more source
Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein
Alzheimer’s Research & Therapy, 2023 Background Progression of Alzheimer’s disease leads to synapse loss, neural network dysfunction and cognitive failure. Accumulation of protein aggregates and brain immune activation have triggering roles in synaptic failure but the neuronal mechanisms ...
Austin Stoner +8 more
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Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle. [PDF]
PLoS ONE, 2016 Previous investigations aimed at determining whether the mammalian prion protein actually facilitates tangible molecular aspects of either a discrete or pleiotropic functional niche have been debated, especially given the apparent absence of overt ...
Brian W Brunelle +3 more
doaj +1 more source