Results 41 to 50 of about 9,411 (168)

Prion gene haplotypes of U.S. cattle

BMC Genetics, 2006
Background Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein.
Harhay Gregory P, Smith Timothy PL, Keele John W, Heaton Michael P, Clawson Michael L, Laegreid William W   +5 more
doaj   +1 more source

Identification of Prion Disease-Related Somatic Mutations in the Prion Protein Gene (PRNP) in Cancer Patients

Cells, 2020
Prion diseases are caused by misfolded prion protein (PrPSc) and are accompanied by spongiform vacuolation of brain lesions. Approximately three centuries have passed since prion diseases were first discovered around the world; however, the exact role of
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Sequence variation in the bovine and ovine PRNP genes. [PDF]

, 2003
A resequencing approach was adopted to identify sequence variants in the PRNP gene that may affect susceptibility or resistance to bovine spongiform encephalopathy.
SCHLAEPFER J, MACLEAN I, HILLS D, COMINCINI, SERGIO, DOLF G, WILLIAMS J., FERRETTI, LUCA, OLSAKER I   +7 more
core   +1 more source

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

Frontiers in Cell and Developmental Biology, 2015
Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp-/-) mice.
Akikazu eSakudo, Takashi eOnodera
doaj   +1 more source

Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats. [PDF]

PLoS ONE, 2018
The polymorphisms of the prion protein (PRNP) gene, which encodes normal prion proteins (PrP), are known to be involved in the susceptibility of prion diseases.
Min-Ju Jeong, Yong-Chan Kim, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Distribution of the 23-bp polymorphism of the prion protein gene in Jersey cattles in Turkey

Journal of Experimental and Molecular Biology, 2023
Background: Bovine spongiform encephalopathy (BSE) is a prion disease that is always fatal in cattle and is considered an important risk factor for human health.
Melih Sercan USTAOGLU, Serbulent YIGIT, Muhammed Taha Kaya   +2 more
doaj   +1 more source

Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection

Journal of Alzheimer's Disease Reports, 2017
The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure.
Richard Lathe, Jean-Luc Darlix
doaj   +1 more source

Genetic variability of the prion protein gene (PRNP) in thin-tailed and fat-tailed sheep

Open Veterinary Journal
Background: Scrapie is a deadly neurodegenerative transmissible spongiform encephalopathy (TSE) that affects sheep and goats. TSEs are a consequence of polymorphisms of the prion protein gene PRNP, which result in misfolded prion proteins.
Arif Wicaksono, Aris Haryanto, Alek Ibrahim, Anggita Suryandari, Rana Ayuningtyas Adhi Puspita, Medania Purwaningrum   +5 more
doaj   +1 more source

Prevalence of Trinucleotide Expansions in SCA17/TBP and JPH3 Genes and Octapeptide Insertion in PRNP Gene in Iranian Patients with Huntington-Disease like Syndrome

Medical Laboratory Journal, 2020
Background and objective:  Huntingtonchr('39')s disease (HD) is an autosomal dominant disorder that mainly affects adults. Although mutations in the IT15 gene have been known as the main cause of the disease, patients with HD like (HDL) syndrome have ...
mana zakeri, amir hosein babaei, mohamad taghi akbari, shohreh zare, faravar khordadpoor   +4 more
doaj  

PRNP haplotype associated with classical BSE incidence in European Holstein cattle.

PLoS ONE, 2010
Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease of cattle. The bovine prion gene (PRNP) contains regions of both high and low linkage disequilibrium (LD) that appear to be conserved across Bos taurus populations.
Brenda M Murdoch, Michael L Clawson, Samuel Yue, Urmila Basu, Stephanie McKay, Matthew Settles, Rossana Capoferri, William W Laegreid, John L Williams, Stephen S Moore   +9 more
doaj   +1 more source