Results 21 to 30 of about 8,758 (210)

Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection [PDF]

Journal of Alzheimer's Disease Reports, 2017
The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure.
Richard Lathe, Jean-Luc Darlix
doaj   +2 more sources

Prion Protein Gene (PRNP) variation in German and Danish cervids [PDF]

Veterinary Research
The structure of cellular prion proteins encoded by the Prion Protein gene (PRNP) impactssusceptibility to transmissible spongiform encephalopathies, including Chronic Wasting Disease (CWD) in deer.
Dolores Gavier-Widén, Fiona Houston, Groschup, Martin H., Gavier-Widen, Dolores, Katayoun Moazami-Goudarzi, Miroslaw P. Polak, Polak, Miroslaw P., Markus Keller, Moazami-Goudarzi, Katayoun, Małgorzata Natonek-Wiśniewska, Agata Piestrzyńska-Kajtoch, Jörn Gethmann, Christine Fast, Sonja Ernst, Fast, Christine, Natonek-Wiśniewska, Małgorzata, Ernst, Sonja, Piestrzyńska-Kajtoch, Agata, Sadeghi, Balal, Martin H. Groschup, Houston, Fiona, Balal Sadeghi, Gethmann, Jörn, Keller, Markus   +23 more
core   +8 more sources

Comparative genomic organization of the human and bovine PRNP locus

Genomics, 2006
We sequenced a 208-kb BAC clone spanning the bovine prion protein (PRNP) locus, and compared the genomic structure with that of human. As a result, we determined the precise breakpoint between the two syntenic genomes, located on the 5′ UTR of the PRNP ...
Mi-Na Song, Sang-Haeng Choi, Yeo, Jung-Sou, Hong-Seog Park, Dae-Won Kim, Choi, Inho, Sung-Hwa Chae, Han-Ho Choi, Hong-Seog Park, Kim, Dae-Soo, Kim, Dae-Won, Choi, Han-Ho, Song, Mi-Na, I Choi, Jung-Sou Yeo, J S Yeo, Inho Choi, Il-Chul Kim, Kim, Il-Chul, Chae, Sung-Hwa, Choi, Sang-Haeng, Dae Soo Kim, I C Kim, M N Song, Park, Hong-Seog, Dae-Soo Kim   +25 more
core   +3 more sources

RORA Targeting PRNP Modulates Age-Related Cataract via Activation Oxidative Injury-Induced Cellular Senescence and Apoptosis of Lens Epithelial Cells. [PDF]

Aging Cell
The molecular mechanisms of RORA targeting PRNP activate oxidative injury‐induced cellular senescence and apoptosis of lens epithelial cells. Current research confirms that the transcription factor RORA targets PRNP, exacerbating cellular senescence and apoptosis of LECs (Figure 7).
Zou Y, Li W, Zhang J, Cen C, Zheng W, Li R, Cheng H, Liang L, Kang J, Wan W, Hu K, Zheng S.   +11 more
europepmc   +2 more sources

Differential expression of Prnp and Sprn in scrapie infected sheep also reveals Prnp genotype specific differences [PDF]

Biochemical and Biophysical Research Communications, 2009
The central role for PrP in the pathogenesis of the transmissible spongiform encephalopathies (TSEs) is illustrated by the resistance of Prnp(0/0) mice to disease and by the inverse association of Prnp gene dosage with incubation period. Understanding the role of PrP(C) in TSEs necessitates knowledge of expression levels of the Prnp gene during the ...
Gossner, A. G., Bennet, N., Hunter, N., Hopkins, J.   +3 more
openaire   +3 more sources

A Practice Framework for Genetic Testing in Asymptomatic Relatives of Patients With Creutzfeldt-Jakob Disease: Experience and Insights From Israel. [PDF]

Eur J Neurol
Presymptomatic genetic testing for genetic Creutzfeldt‐Jakob disease requires careful balancing of autonomy, psychological preparedness, and potential familial implications. Based on multidisciplinary experience in Israel, we propose a structured framework including pre‐test counseling, psychological appraisal, genetic testing, in‐person results ...
Shir D, Bregman N, David AB, Nathan T, Goldstein O, Gurevich T, Thaler A, Mirelman A, Shiner T, Weisz MG, Shkedi-Rafid S, Ganz G, Shani H, Pras E, Chorin O, Sorkin G, Markus-Bustani K, Merhavi SK, Shechory-Stahl M, Sharav MY, Dicastro M, Trigubov D, Barel D, Kahana E, Fellner A, Korczyn A, Feldman HB, Greenbaum L, Omer N.   +28 more
europepmc   +2 more sources

Epilepsia partialis continua as the presenting manifestation of Creutzfeldt-Jakob disease: A video-polygraphic clinical vignette. [PDF]

Epileptic Disord
Epileptic Disorders, Volume 28, Issue 3, Page 920-924, June 2026.
Cutellè R, Pascarella A, Santoro A, Cianci V, Mammì A, Tripodi GG, Prestandrea C, Gasparini S, Ferlazzo E.   +8 more
europepmc   +2 more sources

IGF-1-induced enhancement of PRNP expression depends on the negative regulation of transcription factor FOXO3a. [PDF]

PLoS ONE, 2013
The conformational conversion of the cellular prion protein (PrP(C)) into its β-sheet-rich scrapie isoform (PrP(Sc)) causes fatal prion diseases, which are also called transmissible spongiform encephalopathies (TSEs).
Ting Liu, Wenjing Yi, Boya Feng, Zheng Zhou, Gengfu Xiao   +4 more
doaj   +1 more source

Downregulated PRNP Facilitates Cell Proliferation and Invasion and Has Effect on the Immune Regulation in Ovarian Cancer

Journal of Immunology Research, 2022
Background. Ovarian cancer (OC) seriously threatens women’s life. Ferroptosis plays an essential role in the initiation and development of OC. However, more molecular targets and mechanisms for ferroptosis in OC remain to be further elucidated.
Kuan Hu, Xiaofang Zhang, Lei Zhou, Juanni Li   +3 more
doaj   +1 more source

Comparative Analysis of PRNP Gene Indel Polymorphism and Expression among Zhongdian Yellow Cattle, Zhongdian Yak, and Their Hybrids

Animals, 2023
Bovine spongiform encephalopathy (BSE) is a fatal disease in cattle caused by misfolded prion proteins and linked to indel polymorphisms in the promoter and intron 1 of the PRNP gene.
Xiaoming He, Sameeullah Memon, Dan Yue, Junhong Zhu, Ying Lu, Xingneng Liu, Heli Xiong, Guozhi Li, Weidong Deng, Dongmei Xi   +9 more
doaj   +1 more source