Results 21 to 30 of about 9,411 (168)

Comparative Analysis of PRNP Gene Indel Polymorphism and Expression among Zhongdian Yellow Cattle, Zhongdian Yak, and Their Hybrids

Animals, 2023
Bovine spongiform encephalopathy (BSE) is a fatal disease in cattle caused by misfolded prion proteins and linked to indel polymorphisms in the promoter and intron 1 of the PRNP gene.
Xiaoming He, Sameeullah Memon, Dan Yue, Junhong Zhu, Ying Lu, Xingneng Liu, Heli Xiong, Guozhi Li, Weidong Deng, Dongmei Xi   +9 more
doaj   +1 more source

Evidence for a pathogenic role of different mutations at codon 188 of PRNP [PDF]

, 2008
Clinical and pathological changes in familial Creutzfeldt-Jakob disease (CJD) cases may be similar or indistinguishable from sporadic CJD. Therefore determination of novel mutations in PRNP remains of major importance.
Eva-Maria Grasbon-Frodl, Hans A Kretzschmar, Roeber, Sigrun, Arzberger, Thomas, Sigrun Roeber, Weber Petra, Krebs, Bjarne, Schröter, Andreas, Petra Weber, Illig, T., Zerr, I., Schröter, A., Arzberger, T., Illig Thomas, Windl, Otto, Bjarne Krebs, Wei Xiang, Hans A. Kretzschmar, Schroeter, Andreas, Kretzschmar, H.A., Inga Zerr, Grasbon-Frodl, Eva-Maria, Weber, Petra, Windl, O., Zerr, Inga, Schröter Andreas, Kretzschmar, Hans A., Xiang, W., Xiang Wei, Illig, Thomas, Zerr Inga, Thomas Illig, Vollmert, C., Grasbon-Frodl Eva-Maria, Kretzschmar Hans A., Caren Vollmert, Weber, P., Krebs Bjarne, Grasbon-Frodl, E.M., Krebs, B., Vollmert Caren, Vollmert, Caren, Roeber Sigrun, Xiang, Wei, Arzberger Thomas, Roeber, S., Windl Otto, Andreas Schröter, Otto Windl, Thomas Arzberger   +49 more
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Association of a bovine prion gene haplotype with atypical BSE. [PDF]

PLoS ONE, 2008
BACKGROUND: Atypical bovine spongiform encephalopathies (BSEs) are recently recognized prion diseases of cattle. Atypical BSEs are rare; approximately 30 cases have been identified worldwide. We tested prion gene (PRNP) haplotypes for an association with
Michael L Clawson, Juergen A Richt, Thierry Baron, Anne-Gaëlle Biacabe, Stefanie Czub, Michael P Heaton, Timothy P L Smith, William W Laegreid   +7 more
doaj   +1 more source

Genetic variability of the prion protein gene (PRNP) in wild ruminants from Italy and Scotland [PDF]

, 2009
The genetics of the prion protein gene (PRNP) play a crucial role in determining the relative susceptibility to transmissible spongiform encephalopathies (TSEs) in several mammalian species.
Acutis, Pier Luigi, Pier Luigi Acutis, Ezio Ferroglio, Simone Peletto, Hugh W. Reid, Perucchini, Matteo, Serena Robetto, Acin, Cristina, Bozzetta, Elena, Reid, Hugh W., Dalgleish, Mark P., Orusa, Riccardo, Elena Bozzetta, Ferroglio, Ezio, Sacchi, Paola, Paula Stewart, Daniela Meloni, Wilfred Goldmann, Meloni, Daniela, Gennero, Silvia, Riccardo Orusa, Roberto Rasero, Rasero, Roberto, Cristina Acín, Matteo Perucchini, Mark P. Dalgleish, Goldmann, Wilfred, Stewart, Paula, Maria Caramelli, Silvia Gennero, Caramelli, Maria, Robetto, Serena, Peletto, Simone, Paola Sacchi   +33 more
core   +1 more source

State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology [PDF]

, 2009
Scrapie is a fatal, neurodegenerative disease of sheep and goats. It is also the earliest known member in the family of diseases classified as transmissible spongiform encephalopathies (TSE) or prion diseases, which includes Creutzfeldt-Jakob disease in ...
Olivier Andreéoletti, Groschup, Martin H., Simone Peletto, Foster, James, Barillet, F., Acin, Cristina, Pierluigi Acutis, Peletto, S., Langeveld, J., Theodoros Sklaviadis, Keulen, L.J.M., van, Bossers, Alex, Vaccari, G., Van Keulen, Lucien, Foster, J., Acin, C., Cristina Acin, Andreoletti, O., Jan Langeveld, Goldmann, Wilfred, Umberto Agrimi, Sklaviadis, T., Vaccari, Gabriele, Langeveld, Jan, van Keulen, L., Groschup, M.H., Peletto, Simone, Bossers, A., Gabriele Vaccari, James Foster, Panagiotidis, C.H., Cynthia H. Panagiotidis, Alex Bossers, Badiola, J. J., Badiola, J.J., van Keulen, L.J.M., Juan J. Badiola, Francis Barillet, Sklaviadis, Theodoros, Barillet, Francis, Langeveld, J.P.M., Wilfred Goldmann, Panagiotidis, Cynthia H., Acutis, Pierluigi, Andreeoletti, O., Badiola, Juan J., Goldmann, W., Panagiotidis, C. H., Groschup, M. H., Andreoletti, Olivier, Acutis, P., Agrimi, Umberto, Lucien Van Keulen, Martin H. Groschup, Agrimi, U.   +54 more
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PRNP expression in breast cancer tissues.

, 2023
Compared with normal breast tissue, a significantly reduced PRNP expression was found in (A) GSE21422, (B) GSE31192, (C) TCGA-BRCA, and (D) GEPTA2. (E) The verification of down-regulated expression of PRNP using the TNM-plot database.
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source

A novel protective prion protein variant that colocalizes with kuru exposure. [PDF]

, 2009
BACKGROUND: Kuru is a devastating epidemic prion disease that affected a highly restricted geographic area of the Papua New Guinea highlands; at its peak, it predominantly affected adult women and children of both sexes.
Whittaker, John, Mein, C., Shah, Paresh, Campbell, T., Whitfield, Jerome, Mein, Charles A, Whittaker, J., Alpers, Michael Philip, Hummerich, H., Collinge, J., Hummerich, Holger, Collinge, John, Uphill, J., Poulter, Mark, Beck, Jon, Al-Dujaily, Huda, Mead, S., Al-Dujaily, H., Alpers, Michael P, Beck, J., Verzilli, C., Mead, Simon, Verzilli, Claudio, Shah, P., Uphill, James, Poulter, M., Campbell, Tracy   +26 more
core   +1 more source

A sequencing strategy for identifying variation throughout the prion gene of BSE-affected cattle

BMC Research Notes, 2008
Background Classical and atypical bovine spongiform encephalopathies (BSEs) are cattle prion diseases. Distinct bovine prion gene (PRNP) alleles have been associated with classical and atypical BSE susceptibility.
Harhay Gregory P, Smith Timothy PL, Keele John W, Heaton Michael P, Clawson Michael L, Richt Juergen A, Laegreid William W   +6 more
doaj   +1 more source

Selected Prnp gRNAs induce Cas9-mediated cleavage within the Prnp ORF.

, 2022
(A) Agarose gel image showing that recCas9 cleaves a half-genomic Prnp expression construct (MoPrP.Xho.wt) when Prnp gRNA–1 is present. A cleavage product of the expected size is indicated by the red arrow.
Serene Wohlgemuth (114866), Luis Arce (12822236), David Westaway (43210), Andrew R. Castle (12822233)   +3 more
core   +1 more source

Creutzfeldt–Jakob disease associated with a T188K homozygous mutation in the prion protein gene: a case report and review of the literature

Prion, 2022
Genetic Creutzfeldt–Jakob disease (gCJD) is a prion disease caused by mutations in the prion protein gene (PRNP). It has an autosomal dominant inheritance, so gCJD with homozygous mutations is extremely rare, and the influence of homozygous mutations on ...
Yuheng Shan, Jiatang Zhang, Yuying Cen, Xiaojiao Xu, Ruishu Tan, Jiahua Zhao, Shengyuan Yu   +6 more
doaj   +1 more source