Results 11 to 20 of about 9,411 (168)

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom [PDF]

Veterinary Research, 2011
The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics
Goldmann Wilfred, Ryan Kelly, Stewart Paula, Parnham David, Xicohtencatl Rosa, Fernandez Nora, Saunders Ginny, Windl Otto, González Lorenzo, Bossers Alex, Foster James   +10 more
doaj   +2 more sources

PRNP expression predicts imaging findings in sporadic Creutzfeldt‐Jakob disease

Annals of Clinical and Translational Neurology, 2023
Objective We explored the relationship between regional PRNP expression from healthy brain tissue and patterns of increased and decreased diffusion and regional brain atrophy in patients with sporadic Creutzfeldt‐Jakob disease (sCJD).
Iris J. Broce, Eduardo Caverzasi, Simone Sacco, Ryan Michael Nillo, Matteo Paoletti, Rahul S. Desikan, Michael Geschwind, Leo P. Sugrue   +7 more
doaj   +2 more sources

Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia [PDF]

BMC Medical Genetics, 2009
Background Polymorphisms of the prion protein gene (PRNP) at codons 129 and 219 play an important role in the susceptibility to Creutzfeldt-Jakob disease (CJD), and might be associated with other neurodegenerative disorders.
Jeong Byung-Hoon, Lee Kyung-Hee, Lee Yun-Jung, Kim Yun, Choi Eun-Kyoung, Kim Young-Hoon, Cho Young-Sook, Carp Richard I, Kim Yong-Sun   +8 more
doaj   +2 more sources

Polymorphism of prion protein gene (PRNP) in Nigerian sheep

Prion, 2023
Polymorphism of the prion protein gene (PRNP) gene determines an animal’s susceptibility to scrapie. Three polymorphisms at codons 136, 154, and 171 have been linked to classical scrapie susceptibility, although many variants of PRNP have been reported ...
Adeniyi C. Adeola, Semiu F. Bello, Abdussamad M. Abdussamad, Akanbi I. Mark, Oscar J. Sanke, Anyebe B. Onoja, Lotanna M. Nneji, Nasiru Abdullahi, Sunday C. Olaogun, Lawal D. Rogo, Godwin F. Mangbon, Shamsudeen L. Pedro, Manasseh P. Hiinan, Muhammad M. Mukhtar, Jebi Ibrahim, Hayatu Saidu, Philip M. Dawuda, Rukayya K. Bala, Hadiza L. Abdullahi, Adebowale E. Salako, Samia Kdidi, Mohamed Habib Yahyaoui, Ting-Ting Yin   +22 more
doaj   +4 more sources

A robust, low- to medium-throughput prnp genotyping system in sheep [PDF]

BMC Infectious Diseases, 2004
Background In many countries breeding programs for resistance to scrapie in sheep are established. Therefore, the demand on genotyping capacities of the polymorphisms of the prion protein gene (prnp) relevant to presently known disease associations and ...
Semmer Jördis, Buitkamp Johannes
doaj   +3 more sources

CRISPR/Cas9-editing of PRNP in Alpine goats

Veterinary Research
Misfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease.
Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux   +19 more
doaj   +2 more sources

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System. [PDF]

Adv Sci (Weinh)
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Rankovic B, Geisterfer ZM, Chhabra A, Jovanovic VM, Seim I, Hoffmann C, Condric A, Aguilar Pérez G, de Boer R, Hofstede LT, Sun J, Freitag K, Nowick K, Jendrach M, Heppner FL, Despic V, Müller-McNicoll M, Sigrist S, Bogaart GVD, Reshetniak S, Gladfelter AS, Milovanovic D.   +21 more
europepmc   +2 more sources

Aptamer-Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN-STAT3 Complex and Enables Liquid Biopsy Detection. [PDF]

Adv Sci (Weinh)
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Wang C, Wu H, Zheng C, Zhang H, Wu X, Wang J, Chang Z, Xiang J, Liu Y, Zhang C, Wang Y, Jiang H, Zhong Y, Luo J, Chen Y, Zhang N, Zhang W, Yuan Z, Zou C, Tan W, Wang M, Hu H, Bing T, Wang G.   +23 more
europepmc   +2 more sources

Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility [PDF]

, 2005
The susceptibility of humans to the variant Creutzfeldt-Jakob disease is greatly influenced by polymorphisms within the human prion protein gene (PRNP). Similar genetic differences exist in sheep, in which PRNP polymorphisms modify the susceptibility to ...
Sander, Petra, Kashkevich, Kseniya, Henning Hamann, Katrin Schiebel, Hamann, Henning, Petra Sander, Kseniya Kashkevich, Drögemüller, Cord, Leeb, Tosso, Schiebel, Katrin, Tosso Leeb, Cord Drögemüller   +11 more
core   +2 more sources

A Phase-Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease-Associated Protein Aggregation and Guides Suppressor Design. [PDF]

Adv Sci (Weinh)
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Sio JS, Loo WXW, Loo YS, Tan WX, Lim HX, Liu H, Ng CS.   +6 more
europepmc   +2 more sources