Results 11 to 20 of about 8,758 (210)

CRISPR/Cas9-editing of PRNP in Alpine goats

Veterinary Research
Misfolding of the cellular PrP (PrPc) protein causes prion disease, leading to neurodegenerative disorders in numerous mammalian species, including goats. A lack of PrPc induces complete resistance to prion disease.
Aurélie Allais-Bonnet, Christophe Richard, Marjolaine André, Valérie Gelin, Marie-Christine Deloche, Aurore Lamadon, Gwendoline Morin, Béatrice Mandon-Pépin, Eugénie Canon, Dominique Thépot, Johann Laubier, Katayoun Moazami-Goudarzi, Ludivine Laffont, Olivier Dubois, Thierry Fassier, Patrice Congar, Olivier Lasserre, Tiphaine Aguirre-Lavin, Jean-Luc Vilotte, Eric Pailhoux   +19 more
doaj   +7 more sources

Polymorphism of prion protein gene (PRNP) in Nigerian sheep

Prion, 2023
Polymorphism of the prion protein gene (PRNP) gene determines an animal’s susceptibility to scrapie. Three polymorphisms at codons 136, 154, and 171 have been linked to classical scrapie susceptibility, although many variants of PRNP have been reported ...
Adeniyi C. Adeola, Semiu F. Bello, Abdussamad M. Abdussamad, Akanbi I. Mark, Oscar J. Sanke, Anyebe B. Onoja, Lotanna M. Nneji, Nasiru Abdullahi, Sunday C. Olaogun, Lawal D. Rogo, Godwin F. Mangbon, Shamsudeen L. Pedro, Manasseh P. Hiinan, Muhammad M. Mukhtar, Jebi Ibrahim, Hayatu Saidu, Philip M. Dawuda, Rukayya K. Bala, Hadiza L. Abdullahi, Adebowale E. Salako, Samia Kdidi, Mohamed Habib Yahyaoui, Ting-Ting Yin   +22 more
doaj   +4 more sources

A nonsense mutation in PRNP associated with clinical Alzheimer's disease. [PDF]

Neurobiology of Aging, 2014
Here, we describe a nonsense haplotype in PRNP associated with clinical Alzheimer's disease. The patient presented an early-onset of cognitive decline with memory loss as the primary cognitive problem.
Guerreiro, Rita, Rademakers, Rosa, Wojtas, Aleksandra, Rademakers, R, Graff-Radford, N, Brás, José, Guerreiro, R, Hardy, J, Brás, J, Wojtas, A, Hardy, John, Graff-Radford, Neill   +11 more
core   +4 more sources

Autoantibodies against the prion protein in individuals with PRNP mutations [PDF]

Neurology, 2020
Objective To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease.
Losa, Marco, Castilla, Joaquín, Epskamp, Mirka, Anane, Alice, Knowles, Tuomas; https://orcid.org/, Minikel, Eric Vallabh; https://orcid.org/, Lutterotti, Andreas, Žáková, Dana, Aguzzi, Adriano; https://orcid.org/, Roiter, Ignazio, Camenisch, Ulrike, Safar, Jiri G, Haïk, Stéphane, Hornemann, Simone; https://orcid.org/, Lindner, Ewald, Frontzek, Karl; https://orcid.org/, Sanchez-Valle, Raquel, Brandel, Jean-Philippe, Carta, Manfredi; https://orcid.org/, Meisl, Georg; https://orcid.org/   +19 more
core   +6 more sources

Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility [PDF]

Journal of Biological Chemistry, 2005
The susceptibility of humans to the variant Creutzfeldt-Jakob disease is greatly influenced by polymorphisms within the human prion protein gene (PRNP). Similar genetic differences exist in sheep, in which PRNP polymorphisms modify the susceptibility to ...
Sander, Petra, Kashkevich, Kseniya, Henning Hamann, Katrin Schiebel, Hamann, Henning, Petra Sander, Kseniya Kashkevich, Drögemüller, Cord, Leeb, Tosso, Schiebel, Katrin, Tosso Leeb, Cord Drögemüller   +11 more
core   +3 more sources

Sequence variation in the bovine and ovine PRNP genes. [PDF]

Animal Genetics, 2003
A resequencing approach was adopted to identify sequence variants in the PRNP gene that may affect susceptibility or resistance to bovine spongiform encephalopathy.
SCHLAEPFER J, MACLEAN I, HILLS D, COMINCINI, SERGIO, DOLF G, WILLIAMS J., FERRETTI, LUCA, OLSAKER I   +7 more
core   +4 more sources

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom [PDF]

Veterinary Research, 2011
The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics
Goldmann Wilfred, Ryan Kelly, Stewart Paula, Parnham David, Xicohtencatl Rosa, Fernandez Nora, Saunders Ginny, Windl Otto, González Lorenzo, Bossers Alex, Foster James   +10 more
doaj   +2 more sources

Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia

BMC Medical Genetics, 2009
Background Polymorphisms of the prion protein gene (PRNP) at codons 129 and 219 play an important role in the susceptibility to Creutzfeldt-Jakob disease (CJD), and might be associated with other neurodegenerative disorders.
Jeong Byung-Hoon, Lee Kyung-Hee, Lee Yun-Jung, Kim Yun, Choi Eun-Kyoung, Kim Young-Hoon, Cho Young-Sook, Carp Richard I, Kim Yong-Sun   +8 more
doaj   +2 more sources

PRNP expression predicts imaging findings in sporadic Creutzfeldt‐Jakob disease

Annals of Clinical and Translational Neurology, 2023
Objective We explored the relationship between regional PRNP expression from healthy brain tissue and patterns of increased and decreased diffusion and regional brain atrophy in patients with sporadic Creutzfeldt‐Jakob disease (sCJD).
Iris J. Broce, Eduardo Caverzasi, Simone Sacco, Ryan Michael Nillo, Matteo Paoletti, Rahul S. Desikan, Michael Geschwind, Leo P. Sugrue   +7 more
doaj   +2 more sources

A robust, low- to medium-throughput prnp genotyping system in sheep

BMC Infectious Diseases, 2004
Background In many countries breeding programs for resistance to scrapie in sheep are established. Therefore, the demand on genotyping capacities of the polymorphisms of the prion protein gene (prnp) relevant to presently known disease associations and ...
Semmer Jördis, Buitkamp Johannes
doaj   +2 more sources