Results 31 to 40 of about 9,411 (168)

APP deficiency and HTRA2 modulates PrPc proteostasis in human cancer cells

BBA Advances, 2022
Cellular protein homeostasis (proteostasis) requires an accurate balance between protein biosynthesis, folding, and degradation, and its instability is causally related to human diseases and cancers. Here, we created numerous engineered cancer cell lines
Denis S.F. Biard, Rafika Jarray, Nicolas Rebergue, François Leteurtre, Dulce Papy-Garcia   +4 more
doaj   +1 more source

Autoantibodies against the prion protein in individuals with PRNP mutations [PDF]

, 2020
Objective To determine whether naturally occurring autoantibodies against the prion protein are present in individuals with genetic prion disease mutations and controls, and if so, whether they are protective against prion disease.
Losa, Marco, Castilla, Joaquín, Epskamp, Mirka, Anane, Alice, Knowles, Tuomas; https://orcid.org/, Minikel, Eric Vallabh; https://orcid.org/, Lutterotti, Andreas, Žáková, Dana, Aguzzi, Adriano; https://orcid.org/, Roiter, Ignazio, Camenisch, Ulrike, Safar, Jiri G, Haïk, Stéphane, Hornemann, Simone; https://orcid.org/, Lindner, Ewald, Frontzek, Karl; https://orcid.org/, Sanchez-Valle, Raquel, Brandel, Jean-Philippe, Carta, Manfredi; https://orcid.org/, Meisl, Georg; https://orcid.org/   +19 more
core   +1 more source

Age-dependent impairment of eyeblink conditioning in prion protein-deficient mice. [PDF]

PLoS ONE, 2013
Mice lacking the prion protein (PrP(C)) gene (Prnp), Ngsk Prnp (0/0) mice, show late-onset cerebellar Purkinje cell (PC) degeneration because of ectopic overexpression of PrP(C)-like protein (PrPLP/Dpl).
Yasushi Kishimoto, Moritoshi Hirono, Ryuichiro Atarashi, Suehiro Sakaguchi, Tohru Yoshioka, Shigeru Katamine, Yutaka Kirino   +6 more
doaj   +1 more source

Relationship between PRNP expression and immune infiltrating cells in BRCA.

, 2023
(A) Twenty-four types of immune-infiltrating cells related to PRNP expression. The absolute values of Spearman R-value are indicated by the size of round dots.
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source

A polymorphism in the regulatory region of PRNP is associated with increased risk of sporadic Creutzfeldt-Jakob disease

BMC Medical Genetics, 2011
Background Creutzfeldt-Jakob disease (CJD) is a rare transmissible neurodegenerative disorder. An important determinant for CJD risk and phenotype is the M129V polymorphism of the human prion protein gene (PRNP), but there are also other coding and non ...
Will Robert G, Knight Richard SG, Croes Esther A, Bishop Matthew T, Sanchez-Juan Pascual, van Duijn Cornelia M, Manson Jean C   +6 more
doaj   +1 more source

Novel Prion Protein Gene Polymorphisms in Awassi Sheep in Three Regions of the Fertile Crescent

Veterinary Sciences, 2023
Scrapie is a fatal, neurodegenerative disease that affects sheep and goats, and genetic susceptibility to scrapie in sheep is associated with polymorphisms in the prion protein (PRNP) gene. The aim of this study is to identify PRNP polymorphism in Awassi
Faisal S. Rashaydeh, Mehmet A. Yildiz, Abdulrahman S. Alharthi, Hani H. Al-Baadani, Ibrahim A. Alhidary, Hasan Meydan   +5 more
doaj   +1 more source

Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Meissner, Bettina, Bettina Meissner, Zerr, Inga, Redyk, Katharina, Christian Schmidt, Nico von Ahsen, Kretzschmar, Hans A., Lennart Krack, Schmidt, Christian, Roeber, Sigrun, von Ahsen, Nico, Katharina Redyk, Sigrun Roeber, Hans Kretzschmar, Inga Zerr, Krack, Lennart, Kretzschmar, Hans, Schmidt, Christian D., Krack, Lennart A., Ahsen, Nico von   +19 more
core   +1 more source

Goats naturally devoid of PrPC are resistant to scrapie

Veterinary Research, 2020
Prion diseases are progressive and fatal, neurodegenerative disorders described in humans and animals. According to the “protein-only” hypothesis, the normal host-encoded prion protein (PrPC) is converted into a pathological and infectious form (PrPSc ...
Øyvind Salvesen, Arild Espenes, Malin R. Reiten, Tram T. Vuong, Giulia Malachin, Linh Tran, Olivier Andréoletti, Ingrid Olsaker, Sylvie L. Benestad, Michael A. Tranulis, Cecilie Ersdal   +10 more
doaj   +1 more source

Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases. [PDF]

PLoS ONE, 2011
Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD) represent two distinct clinical entities belonging to a wider group, generically named as conformational disorders that share common pathophysiologic mechanisms. It is well-established that the
Olga Calero, María J Bullido, Jordi Clarimón, Ana Frank-García, Pablo Martínez-Martín, Alberto Lleó, María Jesús Rey, Alberto Rábano, Rafael Blesa, Teresa Gómez-Isla, Fernando Valdivieso, Jesús de Pedro-Cuesta, Isidro Ferrer, Miguel Calero   +13 more
doaj   +1 more source

Aberrant expression of PRNP in pan-cancer.

, 2023
(A) mRNA levels of PRNP based on the TIMER2 database. (B) Total protein level of PRNP in normal tissue and BRCA, colon cancer, ovarian cancer, clear cell RCC, UCEC, lung cancer, PAAD, head and neck, glioblastoma and liver cancer tissues from CPTAC. (TIF)
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source