Results 51 to 60 of about 9,411 (168)

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation

Veterinary Research, 2022
The Shadoo and PrP prion protein family members are thought to be functionally related, but previous knockdown/knockout experiments in early mouse embryogenesis have provided seemingly contradictory results.
Andrea Rau, Bruno Passet, Johan Castille, Nathalie Daniel-Carlier, Alexandre Asset, Jérome Lecardonnel, Marco Moroldo, Florence Jaffrézic, Denis Laloë, Katayoun Moazami-Goudarzi, Jean-Luc Vilotte   +10 more
doaj   +1 more source

A nonsense mutation in PRNP associated with clinical Alzheimer's disease. [PDF]

, 2014
Here, we describe a nonsense haplotype in PRNP associated with clinical Alzheimer's disease. The patient presented an early-onset of cognitive decline with memory loss as the primary cognitive problem.
Guerreiro, Rita, Rademakers, Rosa, Wojtas, Aleksandra, Rademakers, R, Graff-Radford, N, Brás, José, Guerreiro, R, Hardy, J, Brás, J, Wojtas, A, Hardy, John, Graff-Radford, Neill   +11 more
core   +1 more source

FOXP2, APOE and PRNP new modulators in primary progressive aphasia [PDF]

, 2012
Primary progressive aphasia (PPA) is a heterogeneous disorder characterized by progressive language impairment. Polymorphisms within forkhead box P2 gene (FOXP2) gene have been associated with speech and language impairment.
Masullo, Carlo
core   +2 more sources

Investigating CRISPR/Cas9 gene drive for production of disease-preventing prion gene alleles

PLoS ONE, 2022
Prion diseases are a group of fatal neurodegenerative disorders that includes chronic wasting disease, which affects cervids and is highly transmissible.
Andrew R. Castle, Serene Wohlgemuth, Luis Arce, David Westaway   +3 more
doaj   +2 more sources

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Prediction of Prion Proteins in E. coli Based on Bimodal Sequence Characteristics

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prions are infectious proteins that bear misfolded conformations capable of converting folded states into misfolded aggregates under physiologically relevant conditions. In mammals, prions cause deadly maladies including Creutzfeldt‐Jakob and chronic wasting disease. To date, several prion proteins have been identified in eukaryotes, primarily
Katherine Shreeve, Jinoh Jang, Mridula Srivathsan, Siyu Li, Taylor D. Scott, Silvia Cavagnero   +5 more
wiley   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Novel Polymorphisms and Genetic Characteristics of the Prion Protein Gene in Pheasants

Frontiers in Veterinary Science, 2022
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are fatal neurodegenerative diseases. Prion diseases are caused by abnormal prion protein (PrPSc) derived from normal prion protein (PrPC), which is encoded by the prion ...
Kyung Han Kim, Kyung Han Kim, Yong-Chan Kim, Yong-Chan Kim, Byung-Hoon Jeong, Byung-Hoon Jeong   +5 more
doaj   +1 more source

Cell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment

Glia, Volume 74, Issue 10, October 2026.
Cell type–specific EVs were isolated from mouse brain and profiled by proteomics. Each EV subtype exhibited proteomic signatures consistent with the specialized functions of its cell of origin. Astrocyte‐derived EVs (ADEVs) were enriched for the GlialCAM/MLC1 network and GPCRs.
Alba M. Lucart‐Sanchez, Edward Sellés‐Climent, Jorge Navarro‐Calvo, Guillem Pont‐Espinós, Jose A. Gomez‐Sanchez, Raúl Estévez, Luis M. Valor, Rocío Pérez‐González   +7 more
wiley   +1 more source

PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle [PDF]

, 2007
Background Non-synonymous polymorphisms within the prion protein gene (PRNP) influence the susceptibility and incubation time for transmissible spongiform encephalopathies (TSE) in some species such as sheep and humans.
Dolf, G., Ziegler Ute, Schiebel Katrin, Zurbriggen Andreas, Zurbriggen, Andreas, Groschup, Martin H., Nicken, P., Leeb, T., Groschup, Martin H, Doherr, M.G., Ziegler, Ute, Drögemüller, C., Nicken Petra, Leeb Tosso, Seuberlich, Torsten, Groschup Martin H, Doherr Marcus G, Schiebel, K., Seuberlich, T., Doherr, Marcus G, Dolf Gaudenz, Seuberlich Torsten, Zurbriggen, A., Dolf, Gaudenz, Haase, B., Drögemüller Cord, Drögemüller, Cord, Leeb, Tosso, Schiebel, Katrin, Haase Bianca, Haase, Bianca, Nicken, Petra   +31 more
core   +2 more sources