Results 51 to 60 of about 8,758 (210)

Prion gene haplotypes of U.S. cattle

BMC Genetics, 2006
Background Bovine spongiform encephalopathy (BSE) is a fatal neurological disorder characterized by abnormal deposits of a protease-resistant isoform of the prion protein.
Harhay Gregory P, Smith Timothy PL, Keele John W, Heaton Michael P, Clawson Michael L, Laegreid William W   +5 more
doaj   +1 more source

Aberrant expression of PRNP in pan-cancer.

, 2023
(A) mRNA levels of PRNP based on the TIMER2 database. (B) Total protein level of PRNP in normal tissue and BRCA, colon cancer, ovarian cancer, clear cell RCC, UCEC, lung cancer, PAAD, head and neck, glioblastoma and liver cancer tissues from CPTAC. (TIF)
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source

Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases. [PDF]

PLoS ONE, 2011
Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD) represent two distinct clinical entities belonging to a wider group, generically named as conformational disorders that share common pathophysiologic mechanisms. It is well-established that the
Olga Calero, María J Bullido, Jordi Clarimón, Ana Frank-García, Pablo Martínez-Martín, Alberto Lleó, María Jesús Rey, Alberto Rábano, Rafael Blesa, Teresa Gómez-Isla, Fernando Valdivieso, Jesús de Pedro-Cuesta, Isidro Ferrer, Miguel Calero   +13 more
doaj   +1 more source

Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]

, 2010
Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Meissner, Bettina, Bettina Meissner, Zerr, Inga, Redyk, Katharina, Christian Schmidt, Nico von Ahsen, Kretzschmar, Hans A., Lennart Krack, Schmidt, Christian, Roeber, Sigrun, von Ahsen, Nico, Katharina Redyk, Sigrun Roeber, Hans Kretzschmar, Inga Zerr, Krack, Lennart, Kretzschmar, Hans, Schmidt, Christian D., Krack, Lennart A., Ahsen, Nico von   +19 more
core   +1 more source

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP

Frontiers in Cell and Developmental Biology, 2015
Elucidation of prion protein (PrP) functions is crucial to fully understand prion diseases. A major approach to studying PrP functions is the use of PrP gene-knockout (Prnp-/-) mice.
Akikazu eSakudo, Takashi eOnodera
doaj   +1 more source

Identification of Prion Disease-Related Somatic Mutations in the Prion Protein Gene (PRNP) in Cancer Patients

Cells, 2020
Prion diseases are caused by misfolded prion protein (PrPSc) and are accompanied by spongiform vacuolation of brain lesions. Approximately three centuries have passed since prion diseases were first discovered around the world; however, the exact role of
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats. [PDF]

PLoS ONE, 2018
The polymorphisms of the prion protein (PRNP) gene, which encodes normal prion proteins (PrP), are known to be involved in the susceptibility of prion diseases.
Min-Ju Jeong, Yong-Chan Kim, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Distribution of the 23-bp polymorphism of the prion protein gene in Jersey cattles in Turkey

Journal of Experimental and Molecular Biology, 2023
Background: Bovine spongiform encephalopathy (BSE) is a prion disease that is always fatal in cattle and is considered an important risk factor for human health.
Melih Sercan USTAOGLU, Serbulent YIGIT, Muhammed Taha Kaya   +2 more
doaj   +1 more source

Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation

Veterinary Research, 2022
The Shadoo and PrP prion protein family members are thought to be functionally related, but previous knockdown/knockout experiments in early mouse embryogenesis have provided seemingly contradictory results.
Andrea Rau, Bruno Passet, Johan Castille, Nathalie Daniel-Carlier, Alexandre Asset, Jérome Lecardonnel, Marco Moroldo, Florence Jaffrézic, Denis Laloë, Katayoun Moazami-Goudarzi, Jean-Luc Vilotte   +10 more
doaj   +1 more source

FOXP2, APOE and PRNP new modulators in primary progressive aphasia [PDF]

, 2012
Primary progressive aphasia (PPA) is a heterogeneous disorder characterized by progressive language impairment. Polymorphisms within forkhead box P2 gene (FOXP2) gene have been associated with speech and language impairment.
Masullo, Carlo
core   +2 more sources