Results 71 to 80 of about 8,758 (210)
RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment
Precision Medical Sciences, EarlyView.This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run +7 more
wiley +1 more source
PRNP overexpression sensitizes BRCA cells to gefitinib and improves cellular ROS levels.
, 2023 (A) BT-549 and MDA-MB-231 cells were transiently transfected with Flag-PRNP. PRNP protein expression was measured by western blotting. (B–C) CCK8 experiments were performed and overexpression of PRNP was found to increase the inhibitory effect of ...
Changwei Lin (630203) +3 more
core +1 more source
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias +5 more
wiley +1 more source
, 2014 (A) The PrP protein coding sequence was replaced with GFP protein coding sequence. Rectangles represent exons, which are numbered above. The horizontal line connecting the exons represents DNA and the squiggly lines indicate the continuity of the ...
Clemens Krost (587510) +3 more
core +1 more source
PRNP polymorphisms in Tunisian sheep breeds
Livestock Science, 2014 Abstract In this study, genetic variation of ovine prion protein in Tunisian sheep breeds was analysed. Sequencing of the entire coding sequence of prion protein gene ( PRNP ) was performed in a total of 201 samples belonging to four breeds (Barbarin, Western Thin Tail, Sicilo Sarde and Black Thibar).
S. Kdidi +8 more
openaire +2 more sources
BMC CancerBackground Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC) stands out as a potential candidate
Jacqueline Marcia Boccacino +14 more
doaj +1 more source
A Practical Framework for GT‐Seq Panel Optimization
Molecular Ecology Resources, Volume 26, Issue 5, July 2026.ABSTRACT Genotyping‐in‐thousands by sequencing (GT‐seq) panels are powerful tools in ecological, evolutionary and conservation genomics, yet the optimization process critical for robust and reproducible genotyping remains poorly formalized. Here, we present an iterative workflow for GT‐seq panel optimization that emphasizes systematic refinement ...
Chandika RG +8 more
wiley +1 more source
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Targeting of the Prnp locus with CRISPR/Cas9.
, 2016 (A) Example PCR showing recombination of a 4kb long transgene into Prnp locus using HR Prnp 3 sgRNA; n.c.–negative control; p.c.–positive control; M—marker ladder.
Lech Kaczmarczyk (587512) +3 more
core +1 more source
, 2021 Shadoo, encoded by Sprn , and PrP, encoded by Prnp , are related proteins whose biological functions are still incompletely understood. Although previous knockdown experiments have suggested the necessity of Shadoo in the absence of PrP during early ...
Daniel-Carlier, Nathalie +10 more
core +1 more source