Results 81 to 90 of about 9,411 (168)
, 2021 Shadoo, encoded by Sprn , and PrP, encoded by Prnp , are related proteins whose biological functions are still incompletely understood. Although previous knockdown experiments have suggested the necessity of Shadoo in the absence of PrP during early ...
Daniel-Carlier, Nathalie +10 more
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Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, Volume 36, Issue 4, July 2026.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
The Effects of the PRNP Gene on Circadian Rhythms
, 2014 Fatal Familial Insomnia is a rare genetic disorder affecting about 27 families worldwide, caused by mutations in the prion protein gene PRNP. Symptoms include loss of sleep and disrupted circadian rhythms. The function of PNRP in circadian rhythms is not
Vlasac, Irma Marisela
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Molecular Characterization of the Rocky Mountain Elk (Cervus elaphus nelsoni) PRNP Putative Promoter [PDF]
, 2007 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting deer (Odocoileus spp.), moose (Alces alces), and Rocky Mountain elk (Cervus elaphus nelsoni).
Derr, J. +9 more
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Brain Pathology, Volume 36, Issue 4, July 2026.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Genetic characterization of the prion protein gene in camels (Camelus) with comments on the evolutionary history of prion disease in Cetartiodactyla [PDF]
PeerJTransmissible spongiform encephalopathies (TSEs) are a fatal neurogenerative disease that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE), and several others as well as the recently ...
Emily A. Wright +5 more
doaj +2 more sources
Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
, 2016 Marios P Giannakopoulos,1 Anna G Antonacopoulou,2 Anastasia E Kottorou,2 Haralabos P Kalofonos,2 Sotirios P Gartaganis1 1Department of Ophthalmology, School of Medicine, 2Department of Medicine, Molecular Oncology Laboratory, Division of Oncology ...
Kalofonos HP +4 more
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Identification of two novel mutations, PSEN1 E280K and PRNP G127S, in a Malaysian family
, 2015 Gaik-Siew Ch’ng,1,* Seong Soo A An,2,* Sun Oh Bae,2 Eva Bagyinszky,2 SangYun Kim3,41Department of Genetics, Kuala Lumpur Hospital, Malaysia; 2Department of Bionano Technology, Gachon University, 3Department of Neurology, Seoul National ...
Kim SY +4 more
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, 2012 A) Low power photomicrograph of a primary Prnp+/+ mixed culture showing NG2-positive oligodendrocytes (arrows) grown and differentiated over a GFAP-positive astrocyte monolayer.
Rosalina Gavín (171289) +8 more
core +1 more source
Ovine reference materials and assays for prion genetic testing
BMC Veterinary Research, 2010 Background Genetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests for scoring PRNP codons are essential tools for eradicating scrapie and for evaluating ...
Smith Timothy PL +6 more
doaj +1 more source