Results 101 to 110 of about 8,758 (210)

PUM1 regulates PRNP mRNA via its 3’UTR.

, 2021
(A) qRT-PCR analysis of U251-MG and GIMEN cell lines upon transfection with PUM1 siRNA in 6-well format. PUM1 mRNA was efficiently downregulated. ΔCt values were normalized to those of β-actin (ACTB).
Peter Heutink (39587), Berre Doğançay (11614489), Merve Avar (6029000), Daniel Patrick Pease (11614483), Simone Hornemann (269068), Ashutosh Dhingra (3424031), Elke Schaper (838689), Adriano Aguzzi (49294), Daniel Heinzer (6029003), Marc Emmenegger (11614492), Kevin Maggi (11614495), Simon Mead (237364), Jiang-An Yin (11614486), Anna Spinelli (1511230), Andra Chincisan (6028994)   +14 more
core   +1 more source

Analysis of PRNP Gene Codon 129 Polymorphism in the Greek Population

European Journal of Epidemiology, 2006
Creutzfeldt-Jakob disease (CJD) is a fatal transmissible neurodegenerative prion disease with a rapid progression comprising familial, sporadic, iatrogenic and variant forms. A polymorphism at codon 129 of PRNP gene has been implicated in the development of variant CJD.
Saetta, AA, Michalopoulos, NV, Malamis, G, Papanastasiou, PI, Mazmanian, N, Karlou, M, Kouzoupis, A, Korkolopoulou, P, Patsouris, E   +8 more
openaire   +3 more sources

Two novel PRNP truncating mutations broaden the spectrum of prion amyloidosis [PDF]

, 2018
Truncating mutations in PRNP have been associated with heterogeneous phenotypes ranging from chronic diarrhea and neuropathy to dementia, either rapidly or slowly progressive.
Vincenzo Donadio, D'Angelo, Roberto, Giovanna Calandra-Buonaura, Raffaele Lodi, Calandra-Buonaura, Giovanna, Camilla Terziotti, Terziotti, Camilla, Claudio Graziano, Silvia Piras, Anna Bartoletti-Stella, Capellari, Sabina, Loris Pironi, Pironi, Loris, Piras, Silvia, Roberto D'Angelo, Piero Parchi, Graziano, Claudio, Cortelli, Pietro, Rinaldi, Rita, Simone Baiardi, Lodi, Raffaele, Pietro Cortelli, Baiardi, Simone, Donadio, Vincenzo, Parchi, Piero, Bartoletti-Stella, Anna, Sabina Capellari, Rita Rinaldi   +27 more
core   +1 more source

Identification of the Highly Polymorphic Prion Protein Gene (PRNP) in Frogs (Rana dybowskii)

Animals
Prion diseases are fatal neurodegenerative diseases that can be transmitted by infectious protein particles, PrPScs, encoded by the endogenous prion protein gene (PRNP).
Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim   +3 more
doaj   +1 more source

Absence of single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of the prion protein gene (PRNP) in a large sampling of various chicken breeds

BMC Genomics, 2019
Background Prion diseases are zoonotic diseases with a broad infection spectrum among mammalian hosts and are caused by the misfolded prion protein (PrPSc) derived from the normal prion protein (PrPC), which encodes the prion protein gene (PRNP ...
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Deficiency of prion protein induces impaired autophagic flux in neurons

Frontiers in Aging Neuroscience, 2014
Normal cellular prion protein (PrPC) is highly expressed in the central nervous system. The Zürich I Prnp-deficient mouse strain did not show an abnormal phenotype in initial studies, however, in later studies, deficits in exploratory behavior and short-
Hae-Young eShin, Jeong-Ho ePark, Richard I Carp, Eun-Kyoung eChoi, Eun-Kyoung eChoi, Yong-Sun eKim, Yong-Sun eKim   +6 more
doaj   +1 more source

Accumulation Area of a Japanese PRNP P102L Variant Associated With Gerstmann-Sträussler-Scheinker Disease: The Ariake PRNP P102L Variant

Journal of Clinical Neurology
The coast of Kyushu Island on Ariake Sea in Japan is known to be an accumulation area for patients with a proline-to-leucine substitution mutation at residue 102 (P102L) of the human prion protein gene (PRNP), which is associated with Gerstmann-Sträussler-Scheinker disease. We designated this geographical distribution as the "Ariake PRNP P102L variant."
Kohei Suzuyama, Makoto Eriguchi, Hiromu Minagawa, Hiroyuki Honda, Keita Kai, Tetsuyuki Kitamoto, Hideo Hara   +6 more
openaire   +2 more sources

Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe

Veterinary Research, 2019
Susceptibility to prion diseases is largely determined by the sequence of the prion protein gene (PRNP), which encodes the prion protein (PrP). The recent emergence of chronic wasting disease (CWD) in Europe has highlighted the need to investigate PRNP ...
Amy L. Robinson, Helen Williamson, Mariella E. Güere, Helene Tharaldsen, Karis Baker, Stephanie L. Smith, Sílvia Pérez-Espona, Jarmila Krojerová-Prokešová, Josephine M. Pemberton, Wilfred Goldmann, Fiona Houston   +10 more
doaj   +1 more source

Ovine reference materials and assays for prion genetic testing

BMC Veterinary Research, 2010
Background Genetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests for scoring PRNP codons are essential tools for eradicating scrapie and for evaluating ...
Smith Timothy PL, Freking Brad A, Kalbfleisch Theodore S, Leymaster Kreg A, Heaton Michael P, Clawson Michael L, Laegreid William W   +6 more
doaj   +1 more source

Milk donor and recipient relationships and PRNP genotypes.

, 2018
Milk donor and recipient relationships and PRNP genotypes.
Sally A. Madsen-Bouterse (2802844), David A. Schneider (296568), Rohana P. Dassanayake (2802847), Margaret A. Highland (4594690), Dongyue Zhuang (2802835)   +4 more
core   +1 more source