Results 91 to 100 of about 9,411 (168)

PUM1 regulates PRNP mRNA via its 3’UTR.

, 2021
(A) qRT-PCR analysis of U251-MG and GIMEN cell lines upon transfection with PUM1 siRNA in 6-well format. PUM1 mRNA was efficiently downregulated. ΔCt values were normalized to those of β-actin (ACTB).
Peter Heutink (39587), Berre Doğançay (11614489), Merve Avar (6029000), Daniel Patrick Pease (11614483), Simone Hornemann (269068), Ashutosh Dhingra (3424031), Elke Schaper (838689), Adriano Aguzzi (49294), Daniel Heinzer (6029003), Marc Emmenegger (11614492), Kevin Maggi (11614495), Simon Mead (237364), Jiang-An Yin (11614486), Anna Spinelli (1511230), Andra Chincisan (6028994)   +14 more
core   +1 more source

PRNP is a pan-cancer prognostic and immunity-related to EMT in colorectal cancer

Frontiers in Cell and Developmental Biology
BackgroundPrion protein gene (PRNP) is widely expressed in a variety of tissues. Although the roles of PRNP in several cancers have been investigated, no pan-cancer analysis has revealed its relationship with tumorigenesis and immunity ...
Haifeng Chen, Yao Du, Zhiyuan Kong, Xinghe Liao, Xinghe Liao, Weiping Li   +5 more
doaj   +1 more source

Identification of the Highly Polymorphic Prion Protein Gene (PRNP) in Frogs (Rana dybowskii)

Animals
Prion diseases are fatal neurodegenerative diseases that can be transmitted by infectious protein particles, PrPScs, encoded by the endogenous prion protein gene (PRNP).
Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim   +3 more
doaj   +1 more source

Absence of single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of the prion protein gene (PRNP) in a large sampling of various chicken breeds

BMC Genomics, 2019
Background Prion diseases are zoonotic diseases with a broad infection spectrum among mammalian hosts and are caused by the misfolded prion protein (PrPSc) derived from the normal prion protein (PrPC), which encodes the prion protein gene (PRNP ...
Yong-Chan Kim, Sae-Young Won, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1. [PDF]

, 2001
Human prion diseases have inherited, sporadic, and acquired etiologies. The appearance of the novel acquired prion disease, variant Creutzfeldt-Jakob disease (vCJD), and the demonstration that it is caused by the same prion strain as that causing bovine ...
Campbell, T, Collinge, J, Fisher, Elizabeth, Farrall, M, Mahal, SP, Mead, Simon, Mahal, Sukhvir P, Beck, J, Beck, John, Fisher, E, Collinge, John, Farrall, Martin, Mead, S, Campbell, Tracy   +13 more
core   +1 more source

DNA sequence analysis of codon 211 of the bovine Prnp and codon 200 of the human Prnp.

, 2013
DNA sequence analysis of codon 211 of the bovine Prnp and codon 200 of the human Prnp.
S. Mark Hall (376740), Jürgen A. Richt (148961)   +1 more
core   +1 more source

Deficiency of prion protein induces impaired autophagic flux in neurons

Frontiers in Aging Neuroscience, 2014
Normal cellular prion protein (PrPC) is highly expressed in the central nervous system. The Zürich I Prnp-deficient mouse strain did not show an abnormal phenotype in initial studies, however, in later studies, deficits in exploratory behavior and short-
Hae-Young eShin, Jeong-Ho ePark, Richard I Carp, Eun-Kyoung eChoi, Eun-Kyoung eChoi, Yong-Sun eKim, Yong-Sun eKim   +6 more
doaj   +1 more source

In silico analysis of prnp gene in buffalo (Bubalus bubalis) and comparative analysis with PRNP gene of bovine (bos Taurus)

, 2017
Bu çalışmada, manda populasyonlarında biyoinformatik yöntemlerle prion hastalığı ile ilişkin olan PrP proteinini kodlayan PRNP geni'nin Açık Okuma Çerçevesi'nin (AOÇ) analizi yapılmış, PrP proteininin post-translasyonel modifikasyon olasılıkları ...
Osmanlı, Zarifa
core  

Single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of prion protein gene (PRNP) in Nigerian livestock species

BMC Genomics
Background Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) remain one of the deleterious disorders, which have affected several animal species.
Adeniyi C. Adeola, Semiu F. Bello, Abdussamad M. Abdussamad, Rahamon A. M. Adedokun, Sunday C. Olaogun, Nasiru Abdullahi, Akanbi I. Mark, Anyebe B. Onoja, Oscar J. Sanke, Godwin F. Mangbon, Jebi Ibrahim, Philip M. Dawuda, Adebowale E. Salako, Samia Kdidi, Mohamed Habib Yahyaoui   +14 more
doaj   +1 more source

miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting

Journal of Biomedical Science
Background Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms of lung cancer metastasis is crucial for developing new treatment strategies.
Hsiang-Ling Ho, Shin-Chih Lin, Chao-Wei Chiang, Ching Lin, Che-Wei Liu, Yi-Chen Yeh, Mei-Yu Chen, Teh-Ying Chou   +7 more
doaj   +1 more source