Ovine PRNP untranslated region and promoter haplotype diversity
Journal of General Virology, 2009 The diversity and possible contribution of non-coding regions of the prion protein (PrP) gene (PRNP) to transmissible spongiform encephalopathy susceptibility and PrP regulation are not fully known. This study defined ten ovine PRNP promoters and five untranslated region (UTR) haplotypes found in atypical and classical scrapie cases and healthy control
Ginny C, Saunders +6 more
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Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype
Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.We present the clinical, pathological and prion biophysical features of three atypical cases of the MV1 subtype of sporadic Creutzfeldt–Jakob disease (sCJD). We propose that these heterozygous cases exist on a spectrum ranging from MM1‐like to VV1‐like phenotypes and recommend that subtyping be performed at pH 6.9 to avoid missing atypical or mixed ...
Satish K. Nemani +6 more
wiley +1 more source
, 2012 A) Low power photomicrograph of a primary Prnp+/+ mixed culture showing NG2-positive oligodendrocytes (arrows) grown and differentiated over a GFAP-positive astrocyte monolayer.
Rosalina Gavín (171289) +8 more
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Association of clinical characteristics and PRNP expression in BRCA patients.
, 2023 Association of clinical characteristics and PRNP expression in BRCA patients.
Changwei Lin (630203) +3 more
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Genetic characterization of the prion protein gene in camels (Camelus) with comments on the evolutionary history of prion disease in Cetartiodactyla [PDF]
PeerJTransmissible spongiform encephalopathies (TSEs) are a fatal neurogenerative disease that include Creutzfeldt–Jakob disease in humans, scrapie in sheep and goats, bovine spongiform encephalopathy (BSE), and several others as well as the recently ...
Emily A. Wright +5 more
doaj +2 more sources
Lack of association of the M129V polymorphism of the PRNP gene with pseudoexfoliation syndrome
, 2016 Marios P Giannakopoulos,1 Anna G Antonacopoulou,2 Anastasia E Kottorou,2 Haralabos P Kalofonos,2 Sotirios P Gartaganis1 1Department of Ophthalmology, School of Medicine, 2Department of Medicine, Molecular Oncology Laboratory, Division of Oncology ...
Kalofonos HP +4 more
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DNA sequence analysis of codon 211 of the bovine Prnp and codon 200 of the human Prnp.
, 2013 DNA sequence analysis of codon 211 of the bovine Prnp and codon 200 of the human Prnp.
S. Mark Hall (376740) +1 more
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Acta Neurobiologiae Experimentalis, 2001 Polymorphism at codon 129 of the prion protein gene (PRNP) is implicated both in susceptibility and phenotype of human prion diseases. We characterized the valine and methionine allele frequency at codon 129 in 109 individuals representing the normal Polish population and in 15 Polish CJD cases. The distribution of the genotype was 45% Met/Met, 39% Met/
J, Bratosiewicz +3 more
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Identification of two novel mutations, PSEN1 E280K and PRNP G127S, in a Malaysian family
, 2015 Gaik-Siew Ch’ng,1,* Seong Soo A An,2,* Sun Oh Bae,2 Eva Bagyinszky,2 SangYun Kim3,41Department of Genetics, Kuala Lumpur Hospital, Malaysia; 2Department of Bionano Technology, Gachon University, 3Department of Neurology, Seoul National ...
Kim SY +4 more
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TSE GENETICS IN GOATS. LOOKING OUTSIDE THE PRNP OPEN READING FRAME: MOLECULAR CHARACTERIZATION OF THE PRNP REGULATORY REGIONS AND ASSESSMENT OF THE ROLE OF THE SPRN GENE [PDF]
, 2012 Susceptibility of sheep to scrapie, a transmissible spongiform encephalopathy of small ruminants, is strongly influenced by polymorphisms of the prion protein gene (PRNP) and breeding programs to increase scrapie resistance in sheep populations have been
S. Peletto
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