Results 111 to 120 of about 8,758 (210)

Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.

, 2001
Human prion diseases have inherited, sporadic, and acquired etiologies. The appearance of the novel acquired prion disease, variant Creutzfeldt-Jakob disease (vCJD), and the demonstration that it is caused by the same prion strain as that causing bovine ...
Campbell, T, Collinge, J, Fisher, Elizabeth, Farrall, M, Mahal, SP, Mead, Simon, Mahal, Sukhvir P, Beck, J, Beck, John, Fisher, E, Collinge, John, Farrall, Martin, Mead, S, Campbell, Tracy   +13 more
core   +1 more source

In silico analysis of prnp gene in buffalo (Bubalus bubalis) and comparative analysis with PRNP gene of bovine (bos Taurus)

, 2017
Bu çalışmada, manda populasyonlarında biyoinformatik yöntemlerle prion hastalığı ile ilişkin olan PrP proteinini kodlayan PRNP geni'nin Açık Okuma Çerçevesi'nin (AOÇ) analizi yapılmış, PrP proteininin post-translasyonel modifikasyon olasılıkları ...
Osmanlı, Zarifa
core  

Single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of prion protein gene (PRNP) in Nigerian livestock species

BMC Genomics
Background Prion diseases, also known as transmissible spongiform encephalopathies (TSEs) remain one of the deleterious disorders, which have affected several animal species.
Adeniyi C. Adeola, Semiu F. Bello, Abdussamad M. Abdussamad, Rahamon A. M. Adedokun, Sunday C. Olaogun, Nasiru Abdullahi, Akanbi I. Mark, Anyebe B. Onoja, Oscar J. Sanke, Godwin F. Mangbon, Jebi Ibrahim, Philip M. Dawuda, Adebowale E. Salako, Samia Kdidi, Mohamed Habib Yahyaoui   +14 more
doaj   +1 more source

Effect of a single coding polymorphism in the PRNP gene on PrPˢᶜ levels in prion‐infected sheep lymphoid tissues [PDF]

, 2017
Sheep orally infected with bovine spongiform encephalopathy (BSE) have been employed as a model for analysing the risk of transmission of variant Creutzfeldt‐Jakob disease by blood transfusion.
Tan, Boon Chin
core  

Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent

, 1998
Classical genetic analysis has identified Sinc/Prni as the major gene controlling mouse scrapie incubation time. Sinc/Prni is linked to Prnp, the gene encoding the prion protein (PrP).
David W. Melton, Melton, David W., Richard C. Moore, Manson, Jean C., Patricia A. McBride, McBride, Patricia A., Hope, James, Irene McConnell, James Selfridge, McConnell, Irene, Jean C. Manson, Moore, Richard C., Selfridge, James, James Hope   +13 more
core   +1 more source

miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting

Journal of Biomedical Science
Background Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms of lung cancer metastasis is crucial for developing new treatment strategies.
Hsiang-Ling Ho, Shin-Chih Lin, Chao-Wei Chiang, Ching Lin, Che-Wei Liu, Yi-Chen Yeh, Mei-Yu Chen, Teh-Ying Chou   +7 more
doaj   +1 more source

Hemizygous prion protein gene (PRNP) knockout in cattle fibroblasts

, 2008
Bovine spongiform encephalopathy (BSE) represents a real threat for human health, as has been demonstrated by the causal link with the variant form of Creutzfeldt-Jakob disease.
R. Duchi, C. Viscomi, F. Tagliavini, S. Colleoni, C. Galli, D. Piga, LAZZARI, GIOVANNA, GALLI, CESARE, I. Lagutina, G. Lazzari, G. Rossi, D. Brunetti, M. Catania, M. Zeviani   +13 more
core   +1 more source

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

PRNP/prion protein regulates the secretion of exosomes modulating CAV1/caveolin-1-suppressed autophagy

, 2016
Prion protein modulates many cellular functions including the secretion of trophic factors by astrocytes. Some of these factors are found in exosomes, which are formed within multivesicular bodies (MVBs) and secreted into the extracellular space to ...
Rita Sinigaglia-Coimbra (137245), Marcos V. S. Dias (3203310), Bruna R. Rodrigues (3118707), Martins, Vilma R., Rodrigues, Bruna R., Teixeira, Bianca L., Bianca L. Teixeira (3118695), Glaucia N. M. Hajj (3118704), Dias, Marcos V. S., Vilma R. Martins (3118689), Martín Roffé (3118698), Isabel Porto-Carreiro (3118692), Sinigaglia-Coimbra, Rita [UNIFESP], Roffe, Martin, Porto-Carreiro, Isabel, Hajj, Glaucia N. M.   +15 more
core   +1 more source

PRNP Gene [PDF]

, 2020
openaire   +1 more source