Results 61 to 70 of about 9,411 (168)

Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas

BMC Cancer
Background Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC) stands out as a potential candidate
Jacqueline Marcia Boccacino, Rafael dos Santos Peixoto, Camila Felix de Lima Fernandes, Giovanni Cangiano, Paula Rodrigues Sola, Bárbara Paranhos Coelho, Mariana Brandão Prado, Maria Isabel Melo-Escobar, Breno Pereira de Sousa, Shamini Ayyadhury, Gary D. Bader, Sueli Mieko Oba Shinjo, Suely Kazue Nagahashi Marie, Edroaldo Lummertz da Rocha, Marilene Hohmuth Lopes   +14 more
doaj   +1 more source

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

Aggregate, Volume 7, Issue 9, September 2026.
All‐D peptides that bind monomeric α‐synuclein shift the aggregation equilibrium, dismantle pathogenic fibrils, and suppress seeding activity in vitro and in cells. In a Parkinson's disease mouse model, treatment delays disease progression and extends survival, supporting direct aggregate disassembly as a disease‐modifying therapeutic strategy for ...
Sara Reithofer, Marc Sevenich, Madita Vollmer, Dila Kurtul, Laura Müller, Pelin Özdüzenciler, Laurin Gerhards, Kira Allmeroth, Mathias Wendt, Fahimeh Charbgoo, Sarah Schemmert, Marcel Naumann, Karolina Korostov, Gina Hartmann, Lothar Gremer, Gültekin Tamgüney, Dieter Willbold, Antje Willuweit   +17 more
wiley   +1 more source

Prnp manipulation.

, 2014
(A) The PrP protein coding sequence was replaced with GFP protein coding sequence. Rectangles represent exons, which are numbered above. The horizontal line connecting the exons represents DNA and the squiggly lines indicate the continuity of the ...
Clemens Krost (587510), Lech Kaczmarczyk (587512), Andrew W. Borkowski (587511), Walker S. Jackson (587509)   +3 more
core   +1 more source

PRNP overexpression sensitizes BRCA cells to gefitinib and improves cellular ROS levels.

, 2023
(A) BT-549 and MDA-MB-231 cells were transiently transfected with Flag-PRNP. PRNP protein expression was measured by western blotting. (B–C) CCK8 experiments were performed and overexpression of PRNP was found to increase the inhibitory effect of ...
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source

Entropy‐Driven Innovations: Entropy Stabilized Oxides for High‐Performance Next‐Generation Lithium–Sulfur Batteries

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
This article explores high‐entropy‐stabilized oxides (HEOs) as novel functional materials for addressing critical issues in lithium–sulfur (Li–S) batteries, including lithium polysulfide (LPS) shuttling, inadequate conductivity, and slow redox kinetics.
Hassan Raza, Jialiang Wei, Zhicai Wang, Zhaoyang Lv, Junye Cheng, Jia Xu, Liang An, Yuliang Liu, Sergey Ryazantsev, Shukui Li, Guangping Zheng   +10 more
wiley   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, Volume 15, Issue 3, Page 176-193, September 2026.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Targeting of the Prnp locus with CRISPR/Cas9.

, 2016
(A) Example PCR showing recombination of a 4kb long transgene into Prnp locus using HR Prnp 3 sgRNA; n.c.–negative control; p.c.–positive control; M—marker ladder.
Lech Kaczmarczyk (587512), Ylva Mende (191907), Walker S. Jackson (587509), Branko Zevnik (257460)   +3 more
core   +1 more source

Reassessing the Proposed Creatine–PrP Axis in Endometriosis: Methodological and Mechanistic Considerations

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT The research by Chen et al. (2024) presents an innovative hypothesis linking creatine metabolism to ferroptosis resistance in endometriotic stromal cells via PrP suppression. While conceptually valuable, methodological aspects warrant reflection.
Marco Machado
wiley   +1 more source

Associations between PRNP expression and immune inhibitors, immunomodulators, chemokines, and receptors from the TISIDB database.

, 2023
(A) The top four immune inhibitors linked with PRNP expression. PVRL2 was negatively correlated with PRNP levels, while those of PDCD1LG2, IL10RB, and IDO1 were positively correlated.
Changwei Lin (630203), Jiaqing He (1499947), Liying Song (2802685), Xiaopei Tong (9562448)   +3 more
core   +1 more source

Poliovirus type 1 infection of murine PRNP-knockout neuronal cells

, 2005
Transfection of the prion protein gene (Prnp) into prion-deficient mouse cells was shown to reduce the replication of coxsackievirus B3, an enterovirus. Because mice can be susceptible to poliovirus infection by parenteral routes, the authors tested the ...
NISHIMURA T, ONODERA T, BAJ, ANDREINA, TONIOLO, ANTONIO, BETTACCINI A   +4 more
core   +1 more source