Results 41 to 50 of about 33,090 (271)

Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom [PDF]

, 2011
The application of genetic breeding programmes to eradicate transmissible spongiform encephalopathies in goats is an important aim for reasons of animal welfare as well as human food safety and food security. Based on the positive impact of Prnp genetics
Bossers, A., Windl, O., González Lorenzo, James Foster, Parnham David, Foster James, Alex Bossers, Ryan, K., Goldmann Wilfred, Ginny Saunders, Xicohtencatl Rosa, Kelly Ryan, Paula Stewart, Wilfred Goldmann, Lorenzo González, Foster, J., David Parnham, Stewart Paula, Goldmann, W., Nora Fernandez, A., B., Rosa Xicohtencatl, Fernandez Nora, Bossers Alex, Parnham, D., Saunders, G., Stewart, P., Xicohtencatl, R., Fernandez, N., Windl Otto, Gonzalez, L., Ryan Kelly, Saunders Ginny, Otto Windl   +33 more
core   +1 more source

First Report of Single Nucleotide Polymorphisms (SNPs) of the Leporine Shadow of Prion Protein Gene (SPRN) and Absence of Nonsynonymous SNPs in the Open Reading Frame (ORF) in Rabbits

Animals
Prion disorders are fatal infectious diseases that are caused by a buildup of pathogenic prion protein (PrPSc) in susceptible mammals. According to new findings, the shadow of prion protein (Sho) encoded by the shadow of prion protein gene (SPRN) is ...
Sameeullah Memon, Zerui Wang, Wen-Quan Zou, Yong-Chan Kim, Byung-Hoon Jeong   +4 more
doaj   +1 more source

Comparative genomic analysis of prion genes

BMC Genomics, 2007
Background The homologues of human disease genes are expected to contribute to better understanding of physiological and pathogenic processes. We made use of the present availability of vertebrate genomic sequences, and we have conducted the most ...
Gamulin Vera, Premzl Marko
doaj   +1 more source

Pros and cons of a prion-like pathogenesis in Parkinson's disease [PDF]

, 2011
Background: Parkinson's disease (PD) is a slowly progressive neurodegenerative disorder which affects widespread areas of the brainstem, basal ganglia and cerebral cortex.
Chapman Joab, Hilker, Ruediger, Brotchie, Jonathan M, Hilker, Rüdiger, Hilker Ruediger, Brotchie, Jonathan M., Joab Chapman, Ruediger Hilker, Chapman, Joab, Jonathan M Brotchie, Brotchie Jonathan M   +10 more
core   +1 more source

Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells

BMC Genomics, 2017
Background The function of the prion protein, involved in the so-called prion diseases, remains a subject of intense debate and the possibility that it works as a pleiotropic protein through the interaction with multiple membrane proteins is somehow ...
J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, P. M. Rodrigues, E. P. Melo   +7 more
doaj   +1 more source

The First Genetic Characterization of the SPRN Gene in Pekin Ducks (Anas platyrhynchos domesticus)

Animals
Prion diseases are fatal neurodegenerative disorders characterized by an accumulation of misfolded prion protein (PrPSc) in brain tissues. The shadow of prion protein (Sho) encoded by the shadow of prion protein gene (SPRN) is involved in prion disease ...
Thi-Thuy-Duong Nguyen, Mohammed Zayed, Yong-Chan Kim, Byung-Hoon Jeong   +3 more
doaj   +1 more source

Prion-like protein gene (PRND) polymorphisms associated with scrapie susceptibility in Korean native black goats. [PDF]

PLoS ONE, 2018
The polymorphisms of the prion protein (PRNP) gene, which encodes normal prion proteins (PrP), are known to be involved in the susceptibility of prion diseases.
Min-Ju Jeong, Yong-Chan Kim, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Molecular evolution of the sheep prion protein gene [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2005
Transmissible spongiform encephalopathies (TSEs) are infectious, fatal neurodegenerative diseases characterized by aggregates of modified forms of the prion protein (PrP) in the central nervous system. Well known examples include variant Creutzfeldt-Jakob Disease (vCJD) in humans, BSE in cattle, chronic wasting disease in deer and scrapie in sheep and ...
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The Prion-like domain in the exomer-dependent cargo Pin2 serves as a trans-Golgi retention motif [PDF]

, 2014
Prion and prion-like domains (PLDs) are found in many proteins throughout the animal kingdom. We found that the PLD in the S. cerevisiae exomer-depen- dent cargo protein Pin2 is involved in the regulation of protein transport and localization. The domain
Ritz, Alicja M., Mark Trautwein, Trautwein, Mark, Anne Spang, Spang, Anne, Grassinger, Franziska, Alicja M. Ritz, Franziska Grassinger, Ritz, A. M., Grassinger, F., Spang, A., Trautwein, M.   +11 more
core   +1 more source