Results 11 to 20 of about 148 (137)
Prion-Prion Interactions [PDF]
Prion, 2007 The term prion has been used to describe self-replicating protein conformations that can convert other protein molecules of the same primary structure into its prion conformation. Several different proteins have now been found to exist as prions in Saccharomyces cerevisiae. Surprisingly, these heterologous prion proteins have a strong influence on each
Irina L, Derkatch, Susan W, Liebman
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Arquivos de Neuro-Psiquiatria, 1991 Os autores se propõem a revisar alguns aspectos básicos sobre os prions, alertando sobre a possível participação destes na etiologia de algumas enfermidades degenerativas do sistema nervoso.
Godoy, J. M. +2 more
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Cold Spring Harbor Protocols, 2017 Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of “variants,” each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be
Dmitry, Kryndushkin +3 more
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Cold Spring Harbor Perspectives in Biology, 2011 The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944).
David W, Colby, Stanley B, Prusiner
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Amino acid chalcogen analogues as tools in peptide and protein research
Journal of Peptide Science, Volume 26, Issue 2, February 2020., 2020 Although the chemistry of the chalcogen members oxygen, sulfur, selenium, and the metalloid tellurium are closely intertwined, the respective physicochemical aspects differ significantly imparting specific properties to the chalcogen‐containing side chains of proteinogenic and synthetic amino acids.
Luis Moroder, Hans‐Jürgen Musiol
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Prion protein and prion disease at a glance [PDF]
Journal of Cell Science, 2021 ABSTRACT Prion diseases are neurodegenerative disorders caused by conformational conversion of the cellular prion protein (PrPC) into scrapie prion protein (PrPSc). As the main component of prion, PrPSc acts as an infectious template that recruits and converts normal cellular PrPC into its pathogenic, misfolded isoform. Intriguingly, the
Zhu, Caihong, Aguzzi, Adriano
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Prions: Portable prion domains [PDF]
Current Biology, 2000 Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
Wickner, R.B. +3 more
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The Journal of Infectious Diseases, 2002 The “protein only” hypothesis states that the infectious agent causing transmissible spongiform encephalopathies is a conformational isomer of PrP, a host protein predominantly expressed in brain, and is strongly supported by many lines of evidence. Prion diseases are so far unique among conformational diseases in that they are transmissible, not only ...
C, Weissmann +4 more
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Die atomare dreidimensionale Struktur von Amyloid‐β‐Fibrillen mit der Osaka‐Mutation
Angewandte Chemie, Volume 127, Issue 1, Page 337-342, January 2, 2015., 2015 Die Fibrillenstruktur des Aβ1‐40‐Peptids mit der Osaka‐Mutation (E22Δ), die mit früh auftretender Alzheimer‐Erkrankung in Zusammenhang steht, wurde in atomarer Auflösung erhalten und unterscheidet sich grundlegend von allen bisher vorgeschlagenen Aβ‐Modellen: Sie ist komplex geordnet, wobei sich die Deletionsmutation in einer β‐Schleife der Struktur ...
Anne K. Schütz +9 more
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Proceedings of the National Academy of Sciences, 1984 Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present as genetic, infectious, or sporadic disorders, all of which involve modification of the prion protein (PrP).
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