Results 1 to 10 of about 49,072 (180)

Prion shedding is reduced by chronic wasting disease vaccination. [PDF]

PLoS Pathogens
Chronic wasting disease (CWD) is a strictly fatal and highly contagious prion disease of wild and farmed cervids currently expanding in North America. Prion diseases are caused by conversion of the cellular prion protein to its pathological isoform PrPSc.
Hanaa Ahmed-Hassan, Dalia Abdelaziz, Yo-Ching Cheng, Kevin Low, Shirley Phan, Byron Kruger, Chimoné S Dalton, Lech Kaczmarczyk, Walker S Jackson, Sabine Gilch, Hermann M Schätzl   +10 more
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Combination of structure-based virtual screening, molecular docking and molecular dynamics approaches for the discovery of anti-prion fibril flavonoids

Frontiers in Molecular Biosciences, 2023
Prion diseases are a group of rare neurodegenerative diseases caused by the structural conversion of cellular prion into Scrapie prion resulting aggregated fibrils. Therapy of prion diseases has been developed for several decades, especially drug designs
Cheng-Ping Jheng, Cheng-I Lee, Cheng-I Lee, Cheng-I Lee   +3 more
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Genetic aspects of human prion diseases

Frontiers in Neurology, 2022
Human prion diseases are rapidly progressive and fatal neurodegenerative conditions caused by a disease-causing isoform of the native prion protein. The prion protein gene (PRNP) encodes for the cellular prion protein, which is the biological substrate ...
Brian S. Appleby, Brian S. Appleby, Shashirekha Shetty, Shashirekha Shetty, Mohamed Elkasaby   +4 more
doaj   +1 more source

A high-content neuron imaging assay demonstrates inhibition of prion disease-associated neurotoxicity by an anti-prion protein antibody

Scientific Reports, 2022
There is an urgent need to develop disease-modifying therapies to treat neurodegenerative diseases which pose increasing challenges to global healthcare systems.
Madeleine Reilly, Iryna Benilova, Azadeh Khalili-Shirazi, Christian Schmidt, Parvin Ahmed, Daniel Yip, Parmjit S. Jat, John Collinge   +7 more
doaj   +1 more source

Astrocyte in prion disease: a double-edged sword

Neural Regeneration Research, 2022
Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein (PrPC) into the pathologic isoform PrPSc.
Waqas Tahir, Simrika Thapa, Hermann M Schatzl   +2 more
doaj   +1 more source

Enfermedades por priones: de la clínica a la biología molecular

Acta Neurológica Colombiana, 2023
Las enfermedades ocasionadas por priones son también conocidas como encefalitis espongiformes transmisibles o demencias de tipo infeccioso. En humanos las presentaciones clínicas más reconocidas son la enfermedad de Creutzfeldt-Jakob, el síndrome de ...
Carlos Andrés Villegas Lanau.
doaj   +2 more sources

Anti-Prion Systems in Saccharomyces cerevisiae Turn an Avalanche of Prions into a Flurry

Viruses, 2022
Prions are infectious proteins, mostly having a self-propagating amyloid (filamentous protein polymer) structure consisting of an abnormal form of a normally soluble protein.
Moonil Son, Reed B. Wickner
doaj   +1 more source

Teoría Prión - Enfermedades Priónicas

Acta Neurológica Colombiana, 2015
Un enorme progreso se ha logrado en la identificación, prevención, control y estudio de las enfermedades priónicas. El objetivo de esta actualización es presentar un breve Resumen de la historia de la Teoría Prión, de la participación nacional en ...
Gabriel Toro González, Uriel Esteban Sierra Zuleta, Luis Alberto Gómez Grosso   +2 more
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Conservation of Prion-Like Composition and Sequence in Prion-Formers and Prion-Like Proteins of Saccharomyces cerevisiae

Frontiers in Molecular Biosciences, 2019
Prions in eukaryotes have been linked to diseases, evolutionary capacitance, large-scale genetic control, and long-term memory formation. Prion formation and propagation have been studied extensively in the budding yeast Saccharomyces cerevisiae.
Ting-Yi Su, Paul M. Harrison
doaj   +1 more source

Treatment of Prion Disease with Heterologous Prion Proteins. [PDF]

PLoS ONE, 2015
Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment.
Pamela J Skinner, Hyeon O Kim, Damani Bryant, Nikilyn J Kinzel, Cavan Reilly, Suzette A Priola, Anne E Ward, Patricia A Goodman, Katherine Olson, Davis M Seelig   +9 more
doaj   +1 more source