Results 11 to 20 of about 49,072 (180)

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Animal prion diseases: A review of intraspecies transmission [PDF]

Open Veterinary Journal, 2021
Animal prion diseases are a group of neurodegenerative, transmissible, and fatal disorders that affect several animal species. The causative agent, prion, is a misfolded isoform of normal cellular prion protein, which is found in cells with higher ...
Mauro Julián Gallardo, Fernando Oscar Delgado   +1 more
doaj   +1 more source

Increasing prion propensity by hydrophobic insertion.

PLoS ONE, 2014
Prion formation involves the conversion of proteins from a soluble form into an infectious amyloid form. Most yeast prion proteins contain glutamine/asparagine-rich regions that are responsible for prion aggregation.
Aaron C Gonzalez Nelson, Kacy R Paul, Michelina Petri, Noe Flores, Ryan A Rogge, Sean M Cascarina, Eric D Ross   +6 more
doaj   +1 more source

Early increase and late decrease of purkinje cell dendritic spine density in prion-infected organotypic mouse cerebellar cultures. [PDF]

PLoS ONE, 2013
Prion diseases are infectious neurodegenerative diseases associated with the accumulation of protease-resistant prion protein, neuronal loss, spongiform change and astrogliosis.
Jody L Campeau, Gengshu Wu, John R Bell, Jay Rasmussen, Valerie L Sim   +4 more
doaj   +1 more source

Potential Therapeutic Use of Stem Cells for Prion Diseases

Cells, 2023
Prion diseases are neurodegenerative disorders that are progressive, incurable, and deadly. The prion consists of PrPSc, the misfolded pathogenic isoform of the cellular prion protein (PrPC).
Mohammed Zayed, Sung-Ho Kook, Byung-Hoon Jeong   +2 more
doaj   +1 more source

Encefalopatías subagudas espongiformes transmisibles (ESET) La Teoría Prión - Enfermedades Priónicas

Acta Neurológica Colombiana, 2005
La transmisión de algunas enfermedades entre especies ha atraído la atención de los científicos desde el siglo XVIII. El scrapie, la enfermedad de Creutzfeldt-Jakob y otras encefalopatías espongiformes permitieron identificar nuevos agentes ...
Gabriel Toro González, Oscar Eduardo Pacheco García, Uriel Esteban Sierra Zuleta, Mauricio Beltrán Durán, Arturo Díaz Gómez, Edgar Alberto Parra Saad, Edgar Bonilla Sandoval   +6 more
doaj   +2 more sources

Efficacy of Wex-cide 128 disinfectant against multiple prion strains

PLoS ONE, 2023
Prion diseases are transmissible, fatal neurologic diseases that include Creutzfeldt-Jakob Disease (CJD) in humans, chronic wasting disease (CWD) in cervids, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep.
Chase Baune, Bradley R. Groveman, Andrew G. Hughson, Tina Thomas, Barry Twardoski, Suzette Priola, Bruce Chesebro, Brent Race   +7 more
doaj   +2 more sources

Mechanical Deformation Mechanisms and Properties of Prion Fibrils Probed by Atomistic Simulations

Nanoscale Research Letters, 2017
Prion fibrils, which are a hallmark for neurodegenerative diseases, have recently been found to exhibit the structural diversity that governs disease pathology.
Bumjoon Choi, Taehee Kim, Eue Soo Ahn, Sang Woo Lee, Kilho Eom   +4 more
doaj   +1 more source

Detection of prion infectivity in fat tissues of scrapie-infected mice. [PDF]

PLoS Pathogens, 2008
Distribution of prion infectivity in organs and tissues is important in understanding prion disease pathogenesis and designing strategies to prevent prion infection in animals and humans.
Brent Race, Kimberly Meade-White, Michael B A Oldstone, Richard Race, Bruce Chesebro   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source