Results 111 to 120 of about 37,766 (292)
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
Without magic bullets: the biological basis for public health interventions against protein folding disorders [PDF]
, 2010 Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter
Rodrick Wallace
core +2 more sources
Stochastic Modelling Approach to the Incubation Time of Prionic Diseases
, 2003 Transmissible spongiform encephalopathies like the bovine spongiform encephalopathy (BSE) and the Creutzfeldt-Jakob disease (CJD) in humans are neurodegenerative diseases for which prions are the attributed pathogenic agents.
A. S. Ferreira +15 more
core +1 more source
International Journal of Cancer, EarlyView.What's New? While treatment strategies for solid brain metastases have been relatively uniform across cancer subtypes, tailored approaches are warranted. In this observational study, intracranial recurrences after microsurgical resection occurred significantly earlier and more frequently at distant sites in patients with triple‐negative breast cancer ...
Jonathan Weller +14 more
wiley +1 more source
Journal of the Chinese Chemical Society, EarlyView.While X‐ray crystallography has been the primary method for determining the structures of metalloproteins, cryoEM has taken over this role, illustrated by [4Fe4S]‐cluster containing proteins deposited in the Protein Data Bank. What will be the role for X‐ray crystallography as cryoEM and machine learning methods dominate the initial structural analysis?
Douglas C. Rees
wiley +1 more source
A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein
Emerging Infectious Diseases, 2008 To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates.
Vincent Béringue +6 more
doaj +1 more source
Harvest increase and culling as tools for managing chronic wasting disease in white‐tailed deer
The Journal of Wildlife Management, EarlyView.We used an agent‐based model to simulate the effect of CWD management on a white‐tailed deer population in northwest Indiana and northeast Illinois. Our results suggest that wildlife managers should reconsider how and if they should manage CWD. Abstract Chronic wasting disease (CWD), a transmissible spongiform encephalopathy that affects white‐tailed ...
Jonathan D. Brooks +3 more
wiley +1 more source
Oral transmissibility of prion disease is enhanced by binding to soil particles.
PLoS Pathogens, 2007 Soil may serve as an environmental reservoir for prion infectivity and contribute to the horizontal transmission of prion diseases (transmissible spongiform encephalopathies [TSEs]) of sheep, deer, and elk.
Christopher J Johnson +4 more
doaj +1 more source
Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis
Annals of Neurology, EarlyView.
Kate Durbano +3 more
wiley +1 more source