Results 161 to 170 of about 14,159 (251)

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases. [PDF]

Acta Neuropathol
Masone A, Grasso A, Comerio L, Bruno R, Lavigna G, Vanni I, D'Agostino C, Orrù CD, Caughey B, Altmeppen HC, Castilla J, Giaccone G, Tagliavini F, Di Bari MA, Nonno R, Chiesa R.   +15 more
europepmc   +1 more source

Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP‐Induced Mouse Model of Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Oxidative stress induced by MPTP promotes hnRNP A1/A2–dependent alternative splicing toward PKM2 in dopaminergic neurons. Elevated PKM2 transactivates Nrf2, enhances antioxidant gene expression, and protects neurons from oxidative damage and degeneration.
Meng Mei, Qian‐qian Miao, Meng‐ke Li, Hao‐ran Wang, Jian‐hua Ding, Gang Hu, Yao Wei   +6 more
wiley   +1 more source

Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This review systematically explores exercise as a multi‐target intervention for RBD, highlighting its mechanisms of action and regulatory effects on key pathophysiological processes. ABSTRACT Backgrounds REM sleep behavior disorder (RBD) is a prodromal non‐motor symptom of Parkinson's disease (PD) and other α‐synucleinopathies, affecting approximately ...
Xinhui Qiu, Zihui Wang, Ruixue Xu, Yiying Hu, Weidong Le   +4 more
wiley   +1 more source

Overexpression of bank vole PrP(I109) in mice induces a spontaneous atypical prion disease with sex-dependent onset, early NfL elevation, and universal prion strain permissiveness. [PDF]

Acta Neuropathol Commun
Eraña H, Vidal E, Fernández-Borges N, Charco JM, Díaz-Domínguez CM, Sampedro-Torres-Quevedo C, San-Juan-Ansoleaga M, Fernández-Muñoz E, Galarza-Ahumada J, Pérez-Castro MÁ, Gonçalves-Anjo N, Piñeiro P, Pirisinu L, Di Bari MA, Giler S, Raimondi I, Espinosa JC, Vanni I, D'Agostino C, Rodríguez-Cuesta J, Pasetto L, Bonetto V, González-Martín N, Teijeira S, Zou WQ, Geijo M, Torres JM, Chiesa R, Sánchez-Martín MA, Nonno R, Requena JR, Castilla J.   +31 more
europepmc   +1 more source

Networks of Indirect Contact Promote Spread of an Environmentally Transmitted Pathogen in a Highly Social Species

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using behavioral observations and network simulations, we evaluate direct and indirect transmission of the MTBC pathogen M. mungi in banded mongooses. Incorporating intergroup scent marking reveals that environmentally mediated, socially directed pathways can promote spread at low transmissibility, elevating population prevalence even when direct ...
Jack R. Leitch, Neil R. Jordan, John M. Drake, Michael A. Cant, Kathleen A. Alexander   +4 more
wiley   +1 more source

Oligosaccharyltransferase (OST) complex inhibition effectively treats rodent and human prions. [PDF]

PLoS Pathog
Beauchemin KS, Kun J, Groveman B, Williams K, Salerno F, Francomacaro LM, Robison P, Haigh CL, Supattapone S.   +8 more
europepmc   +1 more source

Extralimital records of the Macaroni Penguin in East Antarctica at multiple locations during the molting season

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract Macaroni Penguins (Eudyptes chrysolophus) are abundant across sub‐Antarctic islands but occur only rarely in East Antarctica. Here, we report three concurrent extralimital records of Macaroni Penguins well south of their typical distribution during the austral summer of 2023–2024.
Benjamin Viola, Marcus Salton, Natacha Planque, Christophe Barbraud, Louise Emmerson   +4 more
wiley   +1 more source

A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation. [PDF]

Acta Neuropathol
Fang A, Tang X, Fleming M, Tancowny B, Wang X, Wang Y, Daude N, Dorosh L, Fleck SC, Rathod V, Coustou V, Cervantes SA, Velásquez CD, Westaway D, Aiken J, McKenzie D, Telling G, Stepanova M, Saupe SJ, Siemer AB, Wille H.   +20 more
europepmc   +1 more source

Creutzfeldt‐Jakob‐Like Presentation in Anti‐AMPAR Encephalitis

Annals of Neurology, Volume 99, Issue 6, Page 1466-1467, June 2026.
Kate Durbano, Marie Belley, Delphine Leclercq, Louis Cousyn   +3 more
wiley   +1 more source

Virgin Coconut Oil Attenuates Diabetic Kidney Disease via Gut Microbiota‐Metabolism‐Inflammation Axis Modulation in Type 2 Diabetic Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study elucidates the multi‐targeted mechanisms of Virgin Coconut Oil (CO) as a dietary intervention for ameliorating Diabetic Kidney Disease (DKD). High‐purity medium‐chain fatty acids (MCFAs, primarily octanoic acid [C8:0] and decanoic acid [C10:0]) in CO significantly remodel the gut microbiota by enriching short‐chain fatty acid (SCFA ...
Keke Shao, Yun Cao, Ruiqi Gao, Xueyun Dong, Xuehui Liu, Hao Xu, Yunhan Xie, Linlin Xu, Jiayuan He, Min Chen, Leilei Zhang, Asmaa Ali, Liang Wu, Pingping Wang   +13 more
wiley   +1 more source