Results 151 to 160 of about 14,159 (251)

mGem: Cut4/Apc1 and its prion form at the cross roads of cell cycle regulation, heterochromatin organization, RNAi, stress response, and evolution. [PDF]

mBio
Sharma S, Singh J.
europepmc   +1 more source

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1115-1124, June 2026.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source

Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains. [PDF]

Proc Natl Acad Sci U S A
DeFranco JP, Bian J, Kim S, Atkinson ZN, Crowell J, Kang HE, Bodrogi HO, Christiansen JR, Díaz-Domínguez CM, Telling GC.   +9 more
europepmc   +1 more source

The psychological experience of living at risk of an autosomal dominant neurological condition: A scoping review

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract As our understanding of genetic risk and the availability of genetic testing increases, consideration of the psychological impact of living at risk for an autosomal dominant neurological condition (ADNC) becomes more pertinent. A systematic search of PsycINFO, MEDLINE, and Web of Science was run to identify studies exploring the psychological ...
Rhianna Brien, Simon Mead, Marc Tibber, Edgar Chan   +3 more
wiley   +1 more source

Assessment of Human BSE Risks Through the Use of <i>Cattle-Derived MBM</i> ^*1 in Chicken, Pig, and Others Feed (Prions). [PDF]

Food Saf (Tokyo)
Food Safety Commission of Japan.
europepmc   +1 more source

5‐Hydroxytryptamine Distribution Alteration in Both Neuron and Synapse of Tg(SOD1*G93A)1gur Mice: A Potential Intervention Candidate Strategy for Amyotrophic Lateral Sclerosis

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou, Menghua Li, Qi Dai, Xiwang Liu, Cheng Li, Huifeng Jiao, Haili Pan, Renshi Xu   +7 more
wiley   +1 more source

Development of a Procedure for Prion Surveillance in the Laboratory Setting. [PDF]

J Infect Dis
Gorski D, Schauer I, Spicker K, Tupaki-Sreepurna A, Wang F, Soto C, Pritzkow S.   +6 more
europepmc   +1 more source

DL‐3‐n‐Butylphthalide Protects Against PrP106−126‐Induced Neurotoxicity Through NRF2 Signaling and OPA1/DRP1‐Mediated Mitochondrial Dynamics

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
NBP counteracts PrP106‐126‐induced neurotoxicity by activating NRF2 and restoring OPA1/DRP1‐mediated mitochondrial dynamics. It suppresses oxidative stress and preserves mitochondrial function and bioenergetics. These actions support NBP as a promising therapeutic candidate for prion‐related neurodegeneration.
Wei Wu, Xixi Zhang, Mingyue Jiang, Ning Ma   +3 more
wiley   +1 more source

Membrane-anchored PrPSc is the trigger for prion synaptotoxicity. [PDF]

PLoS Pathog
Gatdula JRP, Mercer RCC, Alepuz Guillen JA, Vultaggio JS, Harris DA.   +4 more
europepmc   +1 more source

Progress of Immunotherapies in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng, Xu‐hui Kang, Shun‐yu Yao, Xiuli Zhang, Sugimoto Kazuo, Jia Liu, Miao‐qiao Du, Lan‐xin Lin, Dai‐yi Jiang, Quan Chen, Hong Jin   +10 more
wiley   +1 more source