Results 251 to 260 of about 8,300 (285)
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Biochemistry, 1999
Transmissible spongiform encephalopathies (TSEs) are caused by a unique infectious agent which appears to be identical with PrPSc, an oligomeric, misfolded isoform of the cellular prion protein, PrPC. All inherited forms of human TSEs, i.e., familial Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia ...
S, Liemann, R, Glockshuber
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Transmissible spongiform encephalopathies (TSEs) are caused by a unique infectious agent which appears to be identical with PrPSc, an oligomeric, misfolded isoform of the cellular prion protein, PrPC. All inherited forms of human TSEs, i.e., familial Creutzfeldt-Jakob disease, Gerstmann-Sträussler-Scheinker syndrome, and fatal familial insomnia ...
S, Liemann, R, Glockshuber
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ChemInform Abstract: Molecular and Chemical Basis of Prion‐Related Diseases
ChemInform, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. B. L. NG, A. J. DOIG
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Prion Protein-Related Diseases Of Man And Animals
1998Abstract Scrapie, Creutzfeldt-Jakob disease (CJD), Gerstmann- Straussler-Sheinker (GSS) syndrome and related diseases of mink (transmissible mink encephalopathy), mule deer, and elk (chronic wasting disease) are the founder members of a group of diseases called the transmissible degenerative (or spongiform) encephalopathies (TSE); the
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Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein
The Lancet, 2004Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused by dietary or other exposure to bovine spongiform encephalopathy (BSE) prions. The prevalence of preclinical or subclinical prion infection in the UK is currently unknown. Since clinical variant CJD is uniformly associated with tonsillar prion infection, we screened 2000 anonymous surgical
Adam, Frosh +6 more
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The Prion Diseases: Creutzfeldt-Jakob, Gerstmann-Sträussler-Scheinker, and Related Disorders
Journal of Geriatric Psychiatry and Neurology, 1998The prion diseases are an interesting group of neurodegenerative disorders for a variety of reasons. The most obvious is their property of transmissibility, but beyond that they constitute a fascinating example of the diversity of disease expression possible from a common etiologic factor.
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Biochemical and Biophysical Research Communications, 2006
Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer's disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer's peptide Abeta1-28 and the segment of the prion protein Prp185-208.
Barbara, Klajnert +3 more
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Amyloid plaques composed of proteinaceous aggregates are commonly found in brains affected by Alzheimer's disease and spongiform encephalopaties. A structural homology has been recently described for the Alzheimer's peptide Abeta1-28 and the segment of the prion protein Prp185-208.
Barbara, Klajnert +3 more
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Chapter 11. Mouse Models of Prion Protein Related Diseases
2011Prion protein (PrP) related diseases are a heterogeneous group of fatal neurodegenerative conditions featuring aberrancies in the metabolism of the cellular prion protein (PrPC) that lead to the formation of neurotoxic or propagative conformers. Commonly referred to as transmissible spongiform encephalopaties or prion disorders, these diseases can be ...
María Gasset, Adriano Aguzzi
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Mini-Reviews in Medicinal Chemistry, 2008
Nucleic acids catalyse the conversion of alpha-helical prion protein to the beta-structured protein oligomers and amyloids structurally similar to the infectious isoform of protein. Simultaneously, the prion protein, similar to gene regulating proteins, bends, unwinds and condenses nucleic acid.
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Nucleic acids catalyse the conversion of alpha-helical prion protein to the beta-structured protein oligomers and amyloids structurally similar to the infectious isoform of protein. Simultaneously, the prion protein, similar to gene regulating proteins, bends, unwinds and condenses nucleic acid.
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1994
"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen,temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundanoluşan küçük, proteinden zengin, infeksiyöz partiküller" olaraktanımlanabilirler (42).Genetik bilginin nükleik asitlerden proteinlere dönüşümü , molekülerbiyolojinin temel doktrini olarak ...
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"Prionlar, nükleik asitleri modifiye eden işlemlerle inaktive edilemeyen,temel ve gerekli komponent olan hücresel bir proteinin anormal bir izoformundanoluşan küçük, proteinden zengin, infeksiyöz partiküller" olaraktanımlanabilirler (42).Genetik bilginin nükleik asitlerden proteinlere dönüşümü , molekülerbiyolojinin temel doktrini olarak ...
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