Results 181 to 190 of about 3,838,438 (312)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Australian research priorities for inherited retinal diseases: a James Lind Alliance priority setting partnership. [PDF]

BMJ Open
Robertson EG, Hetherington K, Prain M, Ma A, Ayton LN, Jamieson RV, Shepard E, Boyd L, Hall J, Boyd R, Karandrews S, Feller H, Simunovic MP, Grigg JR, Yamamoto K, Wakefield CE, Gonzalez-Cordero A.   +16 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Global medium-term research priority setting for seasonal malaria chemoprevention: results from an eDelphi study. [PDF]

BMJ Glob Health
Richardson S, Steele A, Scott S, Ainsworth J, Eckert E, Tchouatieu AM, Sillah JS, Cuomo-Dannenburg G, Okereke E, Okeh DU, Tonks S, Ndiaye JL, Dentinger C, Rassi C, Baker K.   +14 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Research priorities for the most premature babies born <25 weeks' gestation: results of an international priority setting partnership. [PDF]

Arch Dis Child Fetal Neonatal Ed
Peart S, Ray O, Galletta L, Bates A, Boland RA, Davis PG, Gale C, Johnson S, Kinsella S, Knight M, Owen LS, Pallot L, Prentice TM, Santhanadass P, Stanbury K, Tingay D, Whitehead CL, Manley BJ, Roehr CC, Hardy P, Steering Group.   +20 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Priority setting in critical care: a multicriteria approach to ranking access to Intensive Care Unit beds. [PDF]

BMC Health Serv Res
Dos Santos AFA, Dos Santos LA, Frazão TDC, de Assis AG, de Oliveira MSC, da Costa Júnior JF, da S Ferro PAT, de Souza RP.   +7 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Research priorities for faecal incontinence in adults: A James Lind Alliance priority setting partnership. [PDF]

Colorectal Dis
O'Connor A, Rose SA, Carrington EV, Clements A, Cornish JA, Drake MJ, Dunford LJ, Grainger J, Hallett D, Lough K, Marunda T, Sesay A, Vasant DH, Willson T, Dudding T.   +14 more
europepmc   +1 more source