Results 271 to 280 of about 5,438,748 (355)

Identifying research priorities for post-collision care in the United Kingdom: protocol for a road injury priority setting partnership. [PDF]

Scand J Trauma Resusc Emerg Med
Nutbeam T, Leech C, E Baker C, Box E, R Rodgers L, Dungay K, Johnson L, Lee B, MacQueen M, Fenwick R, Marritt I, Dunbar I, Barnard EBG.   +12 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Identifying Research Priorities in Canadian Adult and Pediatric Critical Care: Results From a James Lind Alliance Priority Setting Partnership. [PDF]

Crit Care Med
Fiest KM, Krewulak KD, Rader T, Bain H, Burns KEA, Bergeron MM, Kho ME, Lamontagne F, Lee LA, McKenney S, Menon K, Reid M, Russell K, Sheffield H, Tsang JLY, Murthy S, Canadian Critical Care Trials Group (CCCTG).   +16 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Lipoedema research priorities: a Swedish priority-setting partnership for future treatment and diagnostic studies. [PDF]

BMJ Open
Dahlberg J, Österberg M, Hellberg C, Stenman J, Fundell S, Andersson ÅG, Edling S, Liss A.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Australian research priorities for inherited retinal diseases: a James Lind Alliance priority setting partnership. [PDF]

BMJ Open
Robertson EG, Hetherington K, Prain M, Ma A, Ayton LN, Jamieson RV, Shepard E, Boyd L, Hall J, Boyd R, Karandrews S, Feller H, Simunovic MP, Grigg JR, Yamamoto K, Wakefield CE, Gonzalez-Cordero A.   +16 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Not quite yet: Stakeholder perspectives on health economic evidence use in Non- Communicable Disease priority setting in Kenya

Oguta JO, Wambiya E, Breeze P, Akparibo R, Akoth C, Toweet SK, Mbuthia G, Nyakundi C, Okemwa S, Adjagba A, Dodd PJ.   +10 more
europepmc   +1 more source

Priority setting in dementia palliative care research for people living with dementia and carers: A mixed methods consensus study. [PDF]

Palliat Care Soc Pract
Guo P, Efstathiou N, Bailey C, Adab P, Glasby J.   +4 more
europepmc   +1 more source