Results 141 to 150 of about 251,912 (281)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi +14 more
wiley +1 more source
OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension
Cell Proliferation, EarlyView.This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang +12 more
wiley +1 more source
Prolactin, Estrogen, HbA1c and Interleukin-12 in Iraqi Smokers Single Females
Сахарный диабетBACKGROUND: Smoking disrupts the endocrine system, altering levels of key hormones such as estrogen (E2) and prolactin (PRL). This makes the relationship between smoking and sex hormones an important research topic.
G. S. Jawad +5 more
doaj +1 more source
Physiological and oncogenic roles of the PRL phosphatases
The FEBS Journal, 2018 S. Hardy +5 more
semanticscholar +1 more source
Phosphatase PPP1CC Regulates the First Lineage Segregation by GAS5 in Mouse Preimplantation Embryos
Cell Proliferation, EarlyView.Subcortical GAS5 directs PPP1CC phosphatase spatiotemporal positioning during mouse morula‐blastocyst transition, controlling YAP dephosphorylation to drive first embryonic lineage specification. ABSTRACT The transcriptional effector of the Hippo signalling pathway, YAP, regulates the first lineage specification in mouse preimplantation embryos ...
Jianwu Wang +10 more
wiley +1 more source
„Czterej pancerni i pies” między stereotypem a propagandą, czyli kim byli Czereśniakowie
Literatura i Kultura PopularnaThe portrayal of the Czereśniak family in both the print and TV iterations of Four Tankmen and a Dog constantly strives to achieve a balance between two extremes.
Paweł Kaczyński
doaj +1 more source
Journal of Fish Biology, EarlyView.Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe +4 more
wiley +1 more source
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Surgery is a common treatment for intracranial meningiomas in dogs, although the prognostic impact of the extent of resection (EOR) has not been systematically evaluated. This retrospective study identified prognostic factors associated with clinical outcomes in dogs that underwent surgery and early post‐operative magnetic resonance imaging ...
John H. Rossmeisl +6 more
wiley +1 more source
Root trait dynamics of historical canola varieties under low and high nitrogen supply
The Plant Phenome Journal, Volume 9, Issue 1, December 2026.Abstract Nitrogen fertilizer is a major input cost in crop production, making it crucial to enhance nitrogen use efficiency (NUE) to reduce fertilizer dependence without compromising yields. Root system architecture (RSA) is a key determinant of nutrient acquisition, particularly under nutrient‐limited conditions.
Shankar Pahari, Raju Soolanayakanahally
wiley +1 more source