Results 41 to 50 of about 100,521 (261)
, 1983 Prolactin (PRL) is under short-loop inhibitory control via the hypothalamus. However, earlier studies evaluated the effects on PRL secretion of PRL levels elevated for periods of days. In this study we evaluated the acute effects of intraventricular and
H. K. Mangat, S. M. McCann
core +1 more source
Advanced Science, EarlyView.A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi +23 more
wiley +1 more source
, 2017 Phosphatase of regenerating liver-3 (PRL-3) has been reported to be associated with colon and gastric cancer metastasis. However, the role and function of PRL-3 in human non-small cell lung cancer cells is unknown.
俞松良 +1 more
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Nanobody 19 stabilizes PRL-3 structure at two sites and destabilizes PRL-3 at one interaction point.
, 2023 (A) PRL-3 in complex with nanobody 19 shows regions of both increased (red) and decreased (blue) deuterium uptake, compared to apo-PRL-3. Heatmap indicates approximately 70% sequence coverage by mass spectrometry; gray areas represent portions of PRL-3 ...
K. Martin Chow (772610) +7 more
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Implementation impacts of PRL methodology. [PRL (Plutonium Recovery Limit)] [PDF]
, 1993 This report responds to a DOE-SR request to evaluate the impacts from implementation of the proposed Plutonium Recovery Limit (PRL) methodology. The PRL Methodology is based on cost minimization for decisions to discard or recover plutonium contained in scrap, residues, and other plutonium bearing materials.
Caudill, J. A. +4 more
openaire +2 more sources
Advanced Science, EarlyView.An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu +11 more
wiley +1 more source
, 2020 MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202) +8 more
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Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
, 2020 MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202) +8 more
core +1 more source
Analysis of molecular determinants of PRL‐3 [PDF]
Journal of Cellular and Molecular Medicine, 2009 AbstractIn order to analyse whether a C‐terminal polybasic sequence represents a nuclear localization signal (NLS) we obtained several truncated and mutant forms of protein of regerating liver (PRL)‐3 and evaluated their subcellular localization as compared to the wild‐type form. Our results invalidate the hypothesis that this is an NLS.
Pascaru, Mihaela +6 more
openaire +2 more sources