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Droga ideowa Konstantego Łubieńskiego (1910–1977). Zarys problematyki

Przegląd Nauk Historycznych, 2023
Tematem artykułu jest działalność polityczna i wybory ideowe Konstantego Łubieńskiego (1910–1977), który swoją aktywność zawodową rozpoczynał w około piłsudczykowskim ruchu „mocarstwowym”. Zawsze wrażliwy społecznie, już przed 1939 r. zastanawiał się nad
Ariel Krzysztof Orzełek
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Historiografia PRL

, 2020
Książka jest pierwszą w polskiej literaturze syntetyczną próbą przyjrzenia się fenomenowi historiografii Polski Ludowej. W centrum zainteresowania autora pozostają dzieje struktur organizacyjnych nauki historycznej, w tym relacje historycy–władza, jej założenia teoretyczno-metodologiczne oraz kreowany przez dziejopisów obraz dziejów Polski i historii ...
openaire   +4 more sources

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
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The association of five polymorphisms with milk production traits in Czech Fleckvieh cattle

Czech Journal of Animal Science, 2012
The aim of this study was to estimate allelic and genotypic frequencies of five DNA markers that are positional and functional candidates for milk production traits in Czech Fleckvieh cattle.
J. Boleckova, J. Matejickova, M. Stipkova, J. Kyselova, L. Barton   +4 more
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Image_3_MiR-130a-3p Inhibits PRL Expression and Is Associated With Heat Stress-Induced PRL Reduction.tif

, 2020
MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202), Qianyun Xi (171989), Jiajie Sun (108078), Ting Chen (15205), Jiali Xiong (8177154), Qingyang Jiang (8521728), Baoyu Hu (8177151), Junyi Luo (7362434), Haojie Zhang (1528645)   +8 more
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ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
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Tissue-specific Alterations of PRL-1 and PRL-2 Expression in Cancer [PDF]

, 2012
The PRL-1 and PRL-2 phosphatases have been implicated as oncogenic, however the involvement of these molecules in human neoplasms is not well understood.
Sandusky, George E., Soo, Han Weng, Dumaual, Carmen M., Randall, Stephen K., Crowell, Pamela L., Werner, Sean R.   +5 more
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Linkage disequilibrium (LD) plot across the prolactin (PRL) locus for all racial/ethnic groups combined

, 2011
Copyright information:Taken from "A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort"http://www.biomedcentral.com ...
Joel N Hirschhorn (84601), Christopher A Haiman (23593), Iona Cheng (85330), Noel P Burtt (85328), Laurence N Kolonel (85331), Loreall C Pooler (85329), Sulggi A Lee (85327), Daniel O Stram (23605), Brian E Henderson (23595), Malcolm C Pike (1093), David Altshuler (27754)   +10 more
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NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
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Exploring Contact Binaries: Observational Analysis of Four W Uma Binaries Using Photometry and Spectroscopy

The Astrophysical Journal
We present the multiband photometric and low-resolution spectroscopic analysis of four W Ursae Majoris eclipsing binaries (EWs)—J080510.1+141528 (hereinafter as J0805a), J080516.3+143138 (hereinafter as J0805b), J143358.7+053953 (hereinafter as J1433 ...
A. Panchal, Y. C. Joshi, V. Joshi, A. Chakraborty   +3 more
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