Results 21 to 30 of about 100,521 (261)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source

Image_3_MiR-130a-3p Inhibits PRL Expression and Is Associated With Heat Stress-Induced PRL Reduction.tif

, 2020
MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202), Qianyun Xi (171989), Jiajie Sun (108078), Ting Chen (15205), Jiali Xiong (8177154), Qingyang Jiang (8521728), Baoyu Hu (8177151), Junyi Luo (7362434), Haojie Zhang (1528645)   +8 more
core   +1 more source

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Historiografia PRL

, 2020
Książka jest pierwszą w polskiej literaturze syntetyczną próbą przyjrzenia się fenomenowi historiografii Polski Ludowej. W centrum zainteresowania autora pozostają dzieje struktur organizacyjnych nauki historycznej, w tym relacje historycy–władza, jej założenia teoretyczno-metodologiczne oraz kreowany przez dziejopisów obraz dziejów Polski i historii ...
openaire   +4 more sources

Localized Temperature Monitoring in Mouse Brain during Light Delivery via a Non‐Planar Tapered Fiber‐Integrated µRTD Sensor

Advanced Materials, EarlyView.
We report a multifunctional tapered optical fiber integrating a conformal micro‐resistance temperature detector (µRTD) for local, real‐time thermometry during optical stimulation. The platform combines light‐delivery and temperature sensing within a minimally invasive footprint, enabling detection of sub‐degree cortical heating under representative ...
Antonio Balena, Marco Bianco, Barbara Spagnolo, Muhammad Fayyaz Kashif, Alberto Bramati, Massimo De Vittorio, Ferruccio Pisanello   +6 more
wiley   +1 more source

Pregnancy complications, treatment, and prognosis: Active PRL vs. s-PRL.

, 2014
Data are depicted as n (%).PRL: pregnancy-related lupus.a-PRL: active lupus during pregnancy and puerperium.n-PRL: new-onset lupus during pregnancy and puerperium.f-PRL: flare of established lupus during pregnancy and puerperium.s-PRL: established lupus ...
Wenjie Zheng (20285), Fulin Tang (553949), Huaxia Yang (614419), Qian Wang (32718), Xiaomei Leng (614420), Fengchun Zhang (309978), Hui Liu (33624), Xuan Zhang (56049), Lidan Zhao (553948), Dong Xu (21616)   +9 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Linkage disequilibrium (LD) plot across the prolactin (PRL) locus for all racial/ethnic groups combined

, 2011
Copyright information:Taken from "A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort"http://www.biomedcentral.com ...
Joel N Hirschhorn (84601), Christopher A Haiman (23593), Iona Cheng (85330), Noel P Burtt (85328), Laurence N Kolonel (85331), Loreall C Pooler (85329), Sulggi A Lee (85327), Daniel O Stram (23605), Brian E Henderson (23595), Malcolm C Pike (1093), David Altshuler (27754)   +10 more
core   +1 more source

Table_2_MiR-130a-3p Inhibits PRL Expression and Is Associated With Heat Stress-Induced PRL Reduction.XLSX

, 2020
MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202), Qianyun Xi (171989), Jiajie Sun (108078), Ting Chen (15205), Jiali Xiong (8177154), Qingyang Jiang (8521728), Baoyu Hu (8177151), Junyi Luo (7362434), Haojie Zhang (1528645)   +8 more
core   +1 more source