Results 31 to 40 of about 111,764 (305)

Molecular mechanisms of the PRL phosphatases [PDF]

The FEBS Journal, 2012
The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase.
Pablo, Rios, Xun, Li, Maja, Köhn
openaire   +2 more sources

Multidirectional Investigations on Quiet Time Suprathermal Ions Measured by ASPEX-STEPS on Board Aditya L1

The Astrophysical Journal
The origin, acceleration, and anisotropy of suprathermal ions in the interplanetary medium during quiet time have remained poorly understood issues in solar wind physics.
Aakash Gupta, Dibyendu Chakrabarty, Santosh Vadawale, Aveek Sarkar, Bijoy Dalal, Shiv Kumar Goyal, Jacob Sebastian, P. Janardhan, Nandita Srivastava, M. Shanmugam, Neeraj Kumar Tiwari, Aaditya Sarda, Piyush Sharma, Anil Bhardwaj, Prashant Kumar, Manan S. Shah, Bhas Bapat, Pranav R. Adhyaru, Arpit R. Patel, Hitesh Kumar Adalja, Abhishek Kumar, Tinkal Ladiya, Sushil Kumar, Nishant Singh, Deepak Kumar Painkra, Abhishek J. Verma, Swaroop Banerjee, K. P. Subramanian, M. B. Dadhania   +28 more
doaj   +1 more source

Inhibition of Prolactin (PRL)-Induced Proliferative Signals in Breast Cancer Cells by a Molecular Mimic of Phosphorylated PRL, S179D-PRL [PDF]

Endocrinology, 2003
Abstract Posttranslational modifications of prolactin (PRL), including phosphorylation, vary with physiologic state and alter biologic activity. In light of the growing evidence for a role for PRL in proliferation in mammary cancer, we examined the ability of a mimic of phosphorylated human PRL, S179D-PRL, to initiate signals to several ...
Matthew D, Schroeder, Jennifer L, Brockman, Ameae M, Walker, Linda A, Schuler   +3 more
openaire   +2 more sources

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Kinetics of nanobody binding to PRL-3.

, 2023
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3’s oncogenic functions are not well understood, partly due to a lack of research tools available to study this protein.
K. Martin Chow (772610), Louis B. Hersh (15852915), Zachary A. Williamson (15852912), Konstantin V. Korotkov (9090), Caroline N. Smith (15852909), Kyle Kihn (11876012), Daniel Deredge (6308525), Jessica S. Blackburn (14256575)   +7 more
core   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Klinicheskiy sluchay gigantskoy prolaktin-sekretiruyushchey adenomy gipofiza u podrostka

Ожирение и метаболизм, 2010
Резюме. Пролактиномы редко выявляются у лиц детского возраста, но зачастую характеризуются более агрессивным ростом. И, несмотря на то, что подходы к лечению этих опухолей у взрослых хорошо изучены и в настоящее время предпочтение отдается ...

doaj   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source

Ultra-high-sensitive plasmonic sensor based on asymmetric hexagonal nano-ring resonator for cancer detection

Heliyon
A highly sensitive sensor based on two metal-insulator-metal waveguides coupled to an asymmetric hexagonal nano-ring resonator detecting cancerous cells is proposed. This novel design is utilized to facilitate the sensing of human cells.
Sara Gholinezhad Shafagh, Hassan Kaatuzian   +1 more
doaj   +1 more source

The influence of sGnRH-A and antidopaminergic drug - pimozide - on prolactin mRNA synthesis in female Prussian carp (Carassius gibelio Bloch) in vivo

Czech Journal of Animal Science, 2013
Effects of salmon gonadotropin releasing hormone analogue (sGnRH-A) and antidopaminergic drug, pimozide, on the synthesis of prolactin mRNA in vivo in female Prussian carp (Carassius gibelio Bloch) during two different stages of the reproductive cycle ...
J. Chyb, M. Socha, P. Szczerbik, M. Sokolowska-Mikolajczyk, T. Mikolajczyk, P. Epler   +5 more
doaj   +1 more source