Results 61 to 70 of about 100,521 (261)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA

, 2015
The pattern of PRL secretion depend on the physiological state. Due to insufficient detection sensitivity of existing assays, the precise description of these patterns in mice is lacking.
Bonnefont, Xavier, Chen, Chen, Abitbol, Karine, Martin, Agnès O, Steyn, Frederik, Duvoid-Guillou, Anne, Romano, Nicola, Martin, Agnès O., Guillou, Anne, Mollard, Patrice, Le Tissier, Paul   +10 more
core   +1 more source

Palatable‐Food–Driven Top‐Down Circuit Inhibits PVNCRF Activity to Mitigate Stress Via Peri‐PVNCRFR1 Neurons

Advanced Science, EarlyView.
Palatable food alleviates stress and prevents anxiety. This study uncovers a dedicated neural pathway: dopamine release in the PFC activates D1R neurons, whose projections to the peri‐PVN engage a population of anxiolytic CRFR1 neurons. These neurons then inhibit stress‐induced hyperactivity of PVNCRF neurons, providing a circuit‐level explanation for ...
Yuchuan Hong, Shirui Jun, Tianjiao Deng, Gaojie Shao, Dan Liu, Yi Sun, Yan Chen, Qian Xiao, Jie Shao, Sheng Wang, Tianwen Huang, Fan Yang, Jie Tu   +12 more
wiley   +1 more source

Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1

, 2018
Yongyong Yang,1,* Shenyi Lian,2,* Lin Meng,1,* Zhihua Tian,3 Qin Feng,2 Yue Wang,2 Ping Wang,2 Like Qu,1 Chengchao Shou1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and ...
Tian Z, Shou C, Yang Y, Wang P, Qu L, Lian S, Meng L, Wang Y, Feng Q   +8 more
core  

PRL deficiency results in hippocampal learning defects.

, 2013
(A) The PRL null mice spent significantly less time in the novel arm of a Y-maze compared to their wild-type littermates ...
Tara L. Walker (308979), Eirinn W. Mackay (308981), Daniel G. Blackmore (297180), Margaretha M. Koudijs (308980), Adam S. Hamlin (289993), Rupert W. Overall (122762), Perry F. Bartlett (205720), Jana Vukovic (297181), Alex M. Sykes (308982)   +8 more
core   +1 more source

Nanobody 19 is specific to PRL-3 in immunofluorescence assays.

, 2023
HCT116 colorectal cancer cells were transfected with CMV:GFP-PRL-1, CMV:GFP-PRL-2, or CMV:GFP-PRL-3 for 24 hours prior to cell fixation and permeabilization.
K. Martin Chow (772610), Louis B. Hersh (15852915), Zachary A. Williamson (15852912), Konstantin V. Korotkov (9090), Caroline N. Smith (15852909), Kyle Kihn (11876012), Daniel Deredge (6308525), Jessica S. Blackburn (14256575)   +7 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source

Characterization of PRL-1 and PRL-2 as human oncogenes

, 2004
One of the current goals in cancer research is to find molecular targets which may be exploited in the fight against the disease. A novel family of proteins which are currently being investigated as potential targets is the PRL family of phosphatases ...
Werner, Sean Richard
core  

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source