Results 81 to 90 of about 111,764 (305)

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition

, 2017
Phosphatase of regenerating liver-3 (PRL-3) has been reported to be associated with colon and gastric cancer metastasis. However, the role and function of PRL-3 in human non-small cell lung cancer cells is unknown.
俞松良, Lin, Sheng-Yi;Lee, Yue-Xun;Yu, Sung-Liang;Chang, Gee-Chen;Chen, Jeremy J. W.   +1 more
core   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Analysis of GH1, GHR and PRL gene polymorphisms for estimation of the genetic diversity of Buryat and Altai cattle breeds

Вавиловский журнал генетики и селекции, 2018
Small and unique Buryat and Altai cattle breeds of TuranoMongolian origin are well adapted to harsh conditions of the continental climate to be their habitat. However, the population-genetic structure of the breeds has been poorly studied.
I. V. Lazebnaya, A. V. Perchun, B. B. Lhasaranov, O. E. Lazebny, Yu. A. Stolpovskiy   +4 more
doaj   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

EKOLOGIA I OCHRONA ŚRODOWISKA W POLSKIEJ RZECZPOSPOLITEJ LUDOWEJ

Humanities and Social Sciences, 2018
Ideologia komunistyczna zakładała bezwzględne podporządkowanie przyrody człowiekowi mogącemu dowolnie zmieniać i kształtować oblicze Ziemi. Rozpoczęto realizowanie wielkich programów przekształcania środowiska przyrodniczego, które już w krótkim czasie ...
Radosław Domke
doaj   +1 more source

PRL w literaturze i literatura w PRL-u

Dzieciństwo. Literatura i Kultura, 2021
Tematem artykułu recenzyjnego jest monografia Bohater literatury dziecięcej i młodzieżowej z okresu PRL-u. Między kreacją a recepcją autorstwa Małgorzaty Chrobak (2019). W artykule zostały poddane analizie poszczególne rozdziały monografii, w których Chrobak omawia problematykę percepcji PRL-u we współczesnej literaturze dla młodych czytelników ...
openaire   +1 more source

PRL-3 activates mTORC1 in Cancer Progression [PDF]

, 2015
PRL-3, a metastasis-associated phosphatase, is known to exert its oncogenic functions through activation of PI3K/Akt, which is a key regulator of the rapamycin-sensitive mTOR complex 1 (mTORC1), but a coherent link between PRL-3 and activation of mTOR ...
Shen, H.-M, Gupta, Abhishek, Zeng, Qi, Gupta, A, Ye, Z, Park, J.E, Shen, Han-Ming, Al-Aidaroos, Abdul Qader Omer, Park, Jung Eun, Lin, Youbin, Zhang, S.D, Al-Aidaroos, A.Q.O, Ye, Zu, Zhang, Shu Dong, Yuen, H.F, Yuen, Hiu Fung, Lin, Y, Zeng, Q   +17 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Functional Models of Economic Propaganda in Different Political and Economic Systems – Socialism and Capitalism. Example of Selected Forms of Broadcast Advertising Messages in Poland in the Second Half of the Twentieth Century

Studies in Logic, Grammar and Rhetoric, 2019
Marketing communication in modern times is similar to the propaganda model, i.e. persuasive communication in all possible fields of exploitation. The last three decades in Central and Eastern Europe constituted a time of transformation in many areas of ...
Kinal Jarosław
doaj   +1 more source

Halina Evert-Kappesowa, (Co-)Founder of Post-War Polish Byzantine Studies

Studia Ceranea, 2020
This article aims to expand information on the life and academic career of a historian from Łódź, the co-founder of Polish post-war Byzantine studies – Halina Evert-Kappesowa.
Jolanta Kolbuszewska
doaj   +1 more source