Results 91 to 100 of about 111,764 (305)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Implementation impacts of PRL methodology. [PRL (Plutonium Recovery Limit)] [PDF]

, 1993
This report responds to a DOE-SR request to evaluate the impacts from implementation of the proposed Plutonium Recovery Limit (PRL) methodology. The PRL Methodology is based on cost minimization for decisions to discard or recover plutonium contained in scrap, residues, and other plutonium bearing materials.
Caudill, J. A., Krupa, J. F., Meadors, R. E., Odum, J. V., Rodrigues, G. C.   +4 more
openaire   +2 more sources

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Totalitaryzm a PRL

Civitas. Studia z Filozofii Polityki, 2012
Was the PRP an incomplete authoritarianism, a version of corporativism, a new generation of dictatorship, a mixture or a resultant of these classifications in different ratios, or, perhaps, a totalitarian system after all? Our choice of response defines the content of the memory of the common past to which we refer, it determines our attitude to the ...
openaire   +2 more sources

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

A Study on Different Indian Space Agencies and Their Role in Bio Geographical Studies

Shodh Sari
This study explores the contributions of various Indian space agencies to the field of bio-geographical studies, an interdisciplinary area that investigates the interactions between biological life and geographical environments.
Dr. Nisha Chauhan, Manoj Kumar Singh
doaj   +1 more source

Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1

, 2018
Yongyong Yang,1,* Shenyi Lian,2,* Lin Meng,1,* Zhihua Tian,3 Qin Feng,2 Yue Wang,2 Ping Wang,2 Like Qu,1 Chengchao Shou1 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and ...
Tian Z, Shou C, Yang Y, Wang P, Qu L, Lian S, Meng L, Wang Y, Feng Q   +8 more
core  

Nanobodies are specific to PRL-3 in immunofluorescence assays.

, 2023
HCT116 colorectal cancer cells were transfected with CMV:GFP, CMV:GFP-PRL-1, CMV:GFP-PRL-2, or CMV:GFP-PRL-3 for 24 hours prior to cell fixation and permeabilization.
K. Martin Chow (772610), Louis B. Hersh (15852915), Zachary A. Williamson (15852912), Konstantin V. Korotkov (9090), Caroline N. Smith (15852909), Kyle Kihn (11876012), Daniel Deredge (6308525), Jessica S. Blackburn (14256575)   +7 more
core   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Relacje polsko-austriackie u schyłku zimnej wojny w świetle polskich źródeł dyplomatycznych

Przegląd Nauk Historycznych
Przyjęte metody badań historycznych miały za zadanie odpowiedzieć na pytanie, czy państwa wschodnie sąsiadujące z Austrią, ograniczone swym systemem gospodarczym i politycznym, mogły liczyć na pomoc w zakresie inicjowania reform politycznych ...
Agnieszka Kisztelińska-Węgrzyńska
doaj   +1 more source