Results 91 to 100 of about 100,521 (261)

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

La mort du PRL

, 2019
La disparition du PRL, au moment des élections législatives de 1951, surprend peu les observateurs contemporains, dans la mesure où ce parti, qui avait suscité une certaine espérance au moment de sa création en 1945, était depuis plusieurs années ...
Bernard, Mathias
core   +1 more source

Prolactin and Triiodothyronine Modulate Seasonal Variation in Brown Adipose Tissue in Djungarian Hamsters

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Seasonal photoperiodic cycles regulate energy rheostasis in many animals. Brown adipose tissue (BAT) and the liver are key metabolic organs that show remarkable plasticity in response to photoperiodic conditions. Prolactin (PRL) and thyroid hormones are endocrine signals that transmit neural‐derived photoperiodic time measurement encoding to ...
Sayantan Sur, Grace Payling, Calum Stewart, Avalene Tan, Caitlin Diggle, Tyler J. Stevenson   +5 more
wiley   +1 more source

Clinical manifestations: a-PRL vs. Nonpregnant active SLE.

, 2014
Data are depicted as number (%).PRL: pregnancy-related lupus.SLE: systemic lupus erythematosus.a-PRL: active lupus during pregnancy and puerperium.n-PRL: new-onset lupus during pregnancy and puerperium.f-PRL: flare of established lupus during pregnancy ...
Wenjie Zheng (20285), Fulin Tang (553949), Huaxia Yang (614419), Qian Wang (32718), Xiaomei Leng (614420), Fengchun Zhang (309978), Hui Liu (33624), Xuan Zhang (56049), Lidan Zhao (553948), Dong Xu (21616)   +9 more
core   +1 more source

AI‐Powered Gradient Echo Plural Contrast Imaging (AI‐GEPCI)—A Comprehensive Neurological Protocol From a Single MRI Scan

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MRI is essential for diagnosing and monitoring neurological diseases. Conventional protocols require multiple sequences to obtain complementary contrasts, increasing scan time, cost, and tolerability. Generating multiple contrasts from a single acquisition may streamline workflow while maintaining clinical utility.
Jeramy Lewis, Manu S. Goyal, Gregory F. Wu, Yuyang Hu, Alexander L. Sukstanskii, Satya V. V. N. Kothapalli, Anne H. Cross, Ulugbek Kamilov, Dmitriy A. Yablonskiy   +8 more
wiley   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Discrepancy between prolactin (PRL) messenger ribonucleic acid and PRL content in rat fetal pituitary cells: possible role of dopamine

, 1988
peer reviewedData are controversial concerning the time when PRL-synthesizing cells are detected for the first time in the rat pituitary. Using a very sensitive immunocytochemical technique, we could visualize only a few PRL cells before day 10 after ...
Herregodts, P., Martial, Joseph, Vanhaelst, L., Smets, G., Belayew, A., Velkeniers, B., Hooghe-Peters, E. L.   +6 more
core   +1 more source

Interplay of Ser273 Phosphorylation and K268 and K293 Acetylation in PPARγ: Implications for PPARγ Activation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) play a critical role in regulating the transcriptional activity of PPARγ, a nuclear receptor central to glucose and lipid homeostasis. Among these, lysine acetylation at K268 and K293 and phosphorylation at S273 are particularly relevant to insulin sensitivity.
Caique Camargo Malospirito, Marieli Mariano Gonçalves Dias, Gabriel Ernesto Jara, Thayná Mendonça Avelino, Giovanna Blazutti Elias, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira   +6 more
wiley   +1 more source

Sufficient and Efficient Spending on Primary Care Benefits National Health and Health Systems

The Milbank Quarterly, EarlyView.
Policy Points Primary care is undervalued and under‐funded in many countries despite different care and payment models. High‐quality, accessible primary care requires sustained and strategic investment. Team‐based care, sustainable and engaged workforce models, and technology that enhances rather than fragments care are priorities that are shared ...
ROBERT L. PHILLIPS, REBECCA FISHER, CLAIRE JACKSON, DANIELLE MARTIN, TIM OLDE HARTMAN, FELICITY GOODYEAR‐SMITH   +5 more
wiley   +1 more source