Results 71 to 80 of about 111,764 (305)
, 2020 MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202) +8 more
core +1 more source
Advanced Science, EarlyView.In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang +11 more
wiley +1 more source
Characterization of PRL-1 and PRL-2 as human oncogenes
, 2004 One of the current goals in cancer research is to find molecular targets which may be exploited in the fight against the disease. A novel family of proteins which are currently being investigated as potential targets is the PRL family of phosphatases ...
Werner, Sean Richard
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, 2020 MicroRNAs (MiRNAs) play critical roles in the regulation of pituitary function. MiR-130a-3p has previously been found to be down-regulated in prolactinoma, but its roles in prolactin (PRL) regulation and the underlying mechanisms are still unclear.
Yongliang Zhang (122202) +8 more
core +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
Stereoelectronic Effects in the 02-mediated Autoxidation of Reduced Folate Derivatives
Pteridines, 1993 For over forty years pteridinologists have studied the O2-mediated autoxidation of reduced folate derivatives. This effort has resulted in the identification of several transient intermediates and many products. Until now.
Fitzhugh Anthony L.
doaj +1 more source
Nanobody 19 stabilizes PRL-3 structure at two sites and destabilizes PRL-3 at one interaction point.
, 2023 (A) PRL-3 in complex with nanobody 19 shows regions of both increased (red) and decreased (blue) deuterium uptake, compared to apo-PRL-3. Heatmap indicates approximately 70% sequence coverage by mass spectrometry; gray areas represent portions of PRL-3 ...
K. Martin Chow (772610) +7 more
core +1 more source
Advanced Science, EarlyView.Scheme of the KLF9/WTAP/YTHDF2/m6A/CSF1R regulatory axis in osteoclastogenesis and estrogen‐deficient osteoporosis. WTAP‐mediated m6A modification of Csf1r mRNA governs osteoclastogenesis via a YTHDF2‐mediated pathway. Pathological upregulation of KLF9 drives Wtap transcription, leading to increased m6A deposition on the 3’‐UTR of Csf1r mRNA.
Chen Shen +14 more
wiley +1 more source
Rola Józefa Tejchmy w kryzysie grudniowym 1970 r. Meandry rozgrywek na szczytach kierownictwa PZPR
Acta Universitatis Lodziensis: Folia HistoricaCelem artykułu jest przybliżenie roli Józefa Tejchmy podczas kryzysu grudniowego 1970 r. Praca analizuje działania Tejchmy, próbując określić wagę roli odegranej przez niego oraz jego postawę w dniach kryzysu.
Jakub Kuliś
doaj +1 more source
Ожирение и метаболизм, 2014 The goal of our study was to assess the prevalence and characteristics of lipid metabolism disorders in children Krasnodar region of Russia. Overall 6,000 children 10-17 years were included in the study.
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