Results 71 to 80 of about 100,521 (261)

The hippocampal-dependent learning deficit in PRL null mice can be rescued by infusion of PRL into the hippocampus.

open access: yes, 2013
Following a 28-day infusion of either PRL or saline into the hippocampus, PRL−/− and PRL+/+ mice were tested on hippocampal-dependent learning using the Y-maze. When saline was infused into the hippocampus, the PRL null mice spent significantly less time
Tara L. Walker (308979)   +8 more
core   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan   +6 more
wiley   +1 more source

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

open access: yesAdvanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao   +11 more
wiley   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

open access: yesAnnals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa   +6 more
wiley   +1 more source

Surface Charges Guided Quasi‐TEM‐mode Microwave Propagation along Dielectric Nanowire

open access: yesAdvanced Physics Research, EarlyView.
According to Maxwell's equations, a single‐conductor transmission line cannot allow TEM‐mode electromagnetic wave propagation, however, this is based upon the assumption that dielectric material is isolated from the environment. In practice, surface electrostatic charges widely existed in nano‐materials with large surface‐to‐volume ratio.
BoYan Xu   +7 more
wiley   +1 more source

Increased expression of PRL-1 protein correlates with shortened patient survival in human hepatocellular carcinoma

open access: yes, 2012
[[abstract]]"Background The purposes of the current study were to investigate whether overexpression of the PRL-1 is clinically relevant to hepatocellular carcinoma (HCC) and whether expression patterns of PRL-1 in HCC have diagnostic and prognostic ...
蔡進發;Jeffrey, J.P.Tsai;胡若梅;Hu, Rouh-Mei
core  

Comparison of baseline variables between f-PRL and s-PRL at the time of conception.

open access: yes, 2014
Data are depicted as mean ± standard deviation; median, interquartile range; or number (%).PRL: pregnancy-related lupus.f-PRL: flare of established lupus during pregnancy and puerperium.s-PRL: established lupus remained stable during pregnancy and ...
Wenjie Zheng (20285)   +9 more
core   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

open access: yesThe Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy   +3 more
wiley   +1 more source

Tissue-specific Alterations of PRL-1 and PRL-2 Expression in Cancer

open access: yes, 2012
The PRL-1 and PRL-2 phosphatases have been implicated as oncogenic, however the involvement of these molecules in human neoplasms is not well understood.
Sandusky, George E.   +5 more
core  

The precursor deficit in PRL-deficient mice cannot be rescued by the addition of PRL or KCl-induced depolarizarion.

open access: yes, 2013
(A) The addition of 2 ng/ml PRL to cultures of hippocampal cells from adult PRL+/+ mice resulted in a significant increase in neurosphere numbers ...
Tara L. Walker (308979)   +8 more
core   +1 more source

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