Results 111 to 120 of about 111,764 (305)

Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA

, 2015
The pattern of PRL secretion depend on the physiological state. Due to insufficient detection sensitivity of existing assays, the precise description of these patterns in mice is lacking.
Bonnefont, Xavier, Chen, Chen, Abitbol, Karine, Martin, Agnès O, Steyn, Frederik, Duvoid-Guillou, Anne, Romano, Nicola, Martin, Agnès O., Guillou, Anne, Mollard, Patrice, Le Tissier, Paul   +10 more
core   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

Purification of PRL receptors from toad kidney: comparisons with rabbit mammary PRL receptors

, 1988
The binding characteristics of the prolactin (PRL) receptors present in toad (Bufo marinus) kidneys were investigated and compared to those of PRL receptors present in rabbit mammary glands.
J. P. Kraehenbuhl, M. L. Aubert, M. Dunand, B. C. Rossier   +3 more
core   +2 more sources

The hippocampal-dependent learning deficit in PRL null mice can be rescued by infusion of PRL into the hippocampus.

, 2013
Following a 28-day infusion of either PRL or saline into the hippocampus, PRL−/− and PRL+/+ mice were tested on hippocampal-dependent learning using the Y-maze. When saline was infused into the hippocampus, the PRL null mice spent significantly less time
Tara L. Walker (308979), Eirinn W. Mackay (308981), Daniel G. Blackmore (297180), Margaretha M. Koudijs (308980), Adam S. Hamlin (289993), Rupert W. Overall (122762), Perry F. Bartlett (205720), Jana Vukovic (297181), Alex M. Sykes (308982)   +8 more
core   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Comparison of baseline variables between f-PRL and s-PRL at the time of conception.

, 2014
Data are depicted as mean ± standard deviation; median, interquartile range; or number (%).PRL: pregnancy-related lupus.f-PRL: flare of established lupus during pregnancy and puerperium.s-PRL: established lupus remained stable during pregnancy and ...
Wenjie Zheng (20285), Fulin Tang (553949), Huaxia Yang (614419), Qian Wang (32718), Xiaomei Leng (614420), Fengchun Zhang (309978), Hui Liu (33624), Xuan Zhang (56049), Lidan Zhao (553948), Dong Xu (21616)   +9 more
core   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Prolactinomas in the transition from adolescence to young adulthood: A multicentre, retrospective study from the TALENT group. [PDF]

J Neuroendocrinol
Abstract Prolactinomas in the transition age present unique challenges; treatment strategies and long‐term outcomes in this population remain incompletely characterised. This is a multicentre, retrospective study of 110 consecutive patients (33 males) with prolactinomas, aged 15–25 years, across five Italian referral centres (2010–2025).
De Alcubierre D, Giavoli C, Feola T, Cerroni L, Vincenzi L, Profka E, Pedroli A, Puliani G, Pirchio R, Tenuta M, Auriemma RS, Appetecchia ML, Pivonello R, Mantovani G, Isidori AM, Jaffrain-Rea ML, Grossman A, Sbardella E.   +17 more
europepmc   +2 more sources