Results 61 to 70 of about 21,236 (231)

Development of an In Vitro Test Method to Replace an Animal-Based Potency Test for Pertactin Antigen in Multivalent Vaccines

open access: yesVaccines, 2023
There is increasing interest to replace animal-based potency assays used routinely to test vaccines, since they are highly variable, are costly, and present ethical concerns. The development of relevant in vitro assays is part of the solution.
Jason Szeto   +17 more
doaj   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples   +10 more
wiley   +1 more source

Systematic statistical analysis of change in SEIzure interVAL with diazepam nasal spray supports this novel clinical endpoint for immediate‐use seizure medication

open access: yesEpilepsia, EarlyView.
Abstract Objective Appropriate endpoints for daily antiseizure medications may differ from those for intermittent, immediate‐use seizure medications (ISMs). The observed interval between seizure clusters over time (SEIzure interVAL [SEIVAL]) has been proposed as a novel effectiveness endpoint for ISMs.
Wesley T. Kerr   +4 more
wiley   +1 more source

Degree design - exploring creativity from the start [PDF]

open access: yes, 2002
Curriculum design has occupied the attention of academics throughout the ages. In design related degrees the subject matter itself should inspire careful consideration of the structure of an academic programme.
Childs, PRN
core  

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger   +10 more
wiley   +1 more source

PRN sedative prescribing in the elderly [PDF]

open access: yesPsychiatric Bulletin, 2008
Doctors admitting elderly patients to hospital frequently prescribe sedation as required or pro re nata (prn). They may do this for a variety of reasons, including inexperience, habit and to avoid disturbing a medical colleague at night.
Rebecca Rawesh   +2 more
openaire   +1 more source

Molecular mechanisms of loss of Prn expression.

open access: yes, 2012
(A) Deletion of the Prn signal sequence (prn1ΔSS). Prn− isolates (n = 24) have an 84-bp deletion, resulting in a 28-amino acid deletion (Val9 to Trp36) in the N-terminal region. (B) IS481 insertion mutation in Prn1 gene (prn1::IS481). Eight Prn− isolates
Nao Otsuka (183789)   +6 more
core   +1 more source

Plasma Cell Mucositis: A 20‐Year Retrospective Review at a Tertiary Center

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Plasma cell mucositis (PCM) is a rare, chronic inflammatory condition of mucosal surfaces that is likely underdiagnosed and underreported, with limited data on its clinical characteristics, extracavitary involvement, and treatment outcomes.
Miguel A. Aristizabal‐Torres   +4 more
wiley   +1 more source

Children's postoperative 'pro re nata' (PRN) analgesia: Nurses' administration practices

open access: yes, 2014
'Aims and objectives': This paper reports a study aimed at exploring the nursing practices associated with the administration of pro re nata (PRN) postoperative analgesia to children, and at gaining a preliminary understanding of the decisions that ...
Usher, Kim   +2 more
core   +2 more sources

One-Year Outcomes of 1 Dose versus 3 Loading Doses Followed by Pro Re Nata Regimen Using Ranibizumab for Neovascular Age-Related Macular Degeneration: The ARTIS Trial

open access: yesJournal of Ophthalmology, 2019
Purpose. To compare the functional and anatomical outcomes of one dose and three loading doses followed by the pro re nata (PRN) regimen in Chinese neovascular age-related macular degeneration (nvAMD) (including polypoidal choroidal vasculopathy (PCV ...
Fenghua Wang   +14 more
doaj   +1 more source

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