Results 171 to 180 of about 8,758 (210)

The brain proteome profile is highly conserved between Prnp −/− and Prnp +/+ mice

NeuroReport, 2008
The aim of this study is to compare the proteome of Prnp-/- (Zürich I) gene-ablated mouse brains with wild-type mouse brains. Fluorescence two-dimensional-difference gel electrophoresis (DIGE) and isotope-coded protein labeling (ICPL) were applied for brain homogenates. Similar quantitative protein profiles (
Anna C, Crecelius, Derrick, Helmstetter, Julia, Strangmann, Gerda, Mitteregger, Thomas, Fröhlich, Georg J, Arnold, Hans A, Kretzschmar   +6 more
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PRNP gene variation in Pakistani cattle and buffaloes

Gene, 2012
Bovine spongiform encephalopathy (BSE) is a neurodegenerative prion protein misfolding disorder of cattle. BSE is of two types, classical BSE and atypical BSE which in turn is of two types, H-type BSE and L-type BSE. Both H-type BSE and L-type BSE are primarily sporadic prion disorders.
Muhammad, Imran, Saqib, Mahmood, Masroor E, Babar, Rashid, Hussain, Muhammad Z, Yousaf, Noman B, Abid, Khalid P, Lone   +6 more
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Production of Prnp −/− goats by gene targeting in adult fibroblasts

Transgenic Research, 2008
Homozygous mice devoid of functional Prnp are resistant to scrapie and prion propagation, but heterozygous mice for Prnp disruption still suffer from prion disease and prion deposition. We have previously generated heterozygous cloned goats with one allele of Prnp functional disruption. To obtain goats with both alleles of Prnp be disrupted which would
Caihong Zhu, Jianquan Chen, Huiqing Yu   +2 more
exaly   +3 more sources

Polymorphism of PRNP codons in the normal Icelandic population

Acta Neurologica Scandinavica, 2006
Polymorphisms in the prion protein gene in humans influence susceptibility to, and phenotype of, prion diseases. Methionine-methionine (MM) homozygosity at codon 129 is a risk factor for sporadic Creutzfeldt-Jakob disease (CJD). Polymorphism at codon 117 and changes in the octapeptide repeat region have been associated with genetic CJD.
G, Georgsson, T, Tryggvason, A D, Jonasdottir, S, Gudmundsson, S, Thorgeirsdottir   +4 more
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Genetic Variability of PRNP in Chinese Indigenous Goats

Biochemical Genetics, 2012
Polymorphism of the prion protein gene (PRNP) is usually associated with scrapie susceptibility or resistance. To determine the variability of PRNP in Chinese indigenous goat breeds, we isolated genomic DNA from goat blood and amplified and sequenced the coding region of the gene.
Rongyan, Zhou, Xianglong, Li, Jianzhong, Xi, Lanhui, Li, Zhenhong, Zhang, Zhujun, Zhao   +5 more
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Frequency distribution of PRNP polymorphisms in the Pakistani population

Gene, 2012
Prion diseases are neurodegenerative conditions caused by misfolding of a normal host-encoded prion protein (PrPC) into pathogenic scrapie prion protein (PrPSc). In human prion diseases, the M129V prion protein polymorphism is known to confer susceptibility to the disease, determines PrPSc conformation and alters clinicopathological phenotypes. To date,
Muhammad, Imran, Saqib, Mahmood, Rashid, Hussain, Noman B, Abid, Khalid P, Lone   +4 more
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PRNP haplotype distribution in Moroccan goats

Animal Genetics, 2009
SummarySusceptibility/resistance to scrapie in sheep and goats is influenced by host prion protein gene (PRNP) genotype. In this study, we report the analysis of prion protein gene polymorphisms in 137 goats of two Moroccan populations: D’man and Chaouni. We found seven previously described amino acid polymorphisms at codons 37, 127, 137, 142, 154, 222
C, Serrano, M, Hammouchi, A, Benomar, J, Lyahyai, B, Ranera, C, Acín, M, el Hamidi, M, Monzón, J J, Badiola, N, Tligui, P, Zaragoza, I, Martín-Burriel   +11 more
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Sex and PRNP Genotype Determination in Preimplantation Caprine Embryos

Reproduction in Domestic Animals, 2010
ContentsThe objective of this study was to test the accuracy of genotype diagnosis after whole amplification of DNA extracted from biopsies obtained by trimming goat embryos and to evaluate the viability of biopsied embryos after vitrification/warming and transfer. Whole genome amplification (WGA) was performed using Multiple Displacement Amplification
Guignot, Florence, Perreau, Christine, Cavarroc, Cecile, Touze, Jean-Luc, Pougnard, Jean Louis, Dupont, Francis, Beckers, J.F., Rémy, B., Babilliot, Jean-Marc, Bed'Hom, Bertrand, Lamorinière, J.M., Mermillod, Pascal, Baril, Gérard   +12 more
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Variant CJD in an individual heterozygous for PRNP codon 129

The Lancet, 2009
A 30-year-old man was admitted to hospital in June, 2008, with a 13-month history of personality change, progres sive unsteadiness, and intellectual decline. He complained of severe leg pain and poor memory. 2 months later he developed visual hallucinations and falsely believed he had an abdominal tumour. Symptoms worsened over the next 3 months.
Diego, Kaski, Simon, Mead, Harpreet, Hyare, Sarah, Cooper, Ravi, Jampana, James, Overell, Richard, Knight, John, Collinge, Peter, Rudge   +8 more
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