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Polymorphisms of the
) that affects sheep and goats. Certain amino acid poly-morphisms of prion protein (PrP) are associated with differ-ent susceptibilities to scrapie. At least 25 codons in the ovine PrP coding region are polymorphic, resulting in 40 different haplotypes (Goldmann and others 2005), although only four polymorphic codons have been linked to scrapie ...
C, Serrano +8 more
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Prnp knockdown in transgenic mice using RNA interference
Transgenic Research, 2008RNA interference has become a widely used approach to perform gene knockdown experiments in cell cultures and more recently transgenic animals. A designed miRNA targeting the prion protein mRNA was built and expressed using the human PRNP promoter. Its efficiency was confirmed in transfected cells and it was used to generate several transgenic mouse ...
Micaela, Gallozzi +16 more
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Polymorphisms of the Prion Protein Gene (PRNP) in a Serbian Population
International Journal of Neuroscience, 2010Prion diseases are a group of etiologically heterogeneous neurodegenerative disorders. We have analyzed the coding region of PRNP gene in 121 healthy citizens of Serbia to determine whether the frequencies of M129V, E219K, and octapeptide repeat number polymorphism.
Dimitrijević, Rajna +8 more
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PRNP polymorphisms in four Italian sheep breeds
Livestock Science, 2015Prions are responsible for transmissible spongiform encephalopathies (TSEs), also called scrapie in sheep. Single nucleotide polymorphisms (SNPs) in PRNP have been shown to play a crucial role in terms of incubation period and/or susceptibility to scrapie.
CURCIO, LUDOVICA +6 more
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High Expression of PRNP Predicts Poor Prognosis in Korean Patients with Gastric Cancer
Cancers, 2022Minseok Choi +2 more
exaly