Results 201 to 210 of about 3,465 (237)

Pro12Ala Polymorphism in PPARγ2 Associated with Depression in Chinese Nonagenarians/Centenarians

Archives of Medical Research, 2009
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been associated with decreased obesity, insulin resistance, type 2 diabetes and other age-associated diseases such as cognitive impairment, hypertension, cancer, osteoarthritis. Each one of these diseases had been linked to depression.
Yue, Ji-Rong, Dong, Bi-Rong, Huang, Chang-Quan, Lu, Zhen-Chan, Wu, Hong-Mei, Zhang, Yan-Ling, Tod A, Mattis   +6 more
openaire   +4 more sources

The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

Biochemical and Biophysical Research Communications, 2000
Peroxisome proliferator-activated receptor gamma (PPARgamma) has been implicated in adipocyte differentiation. Recently it was reported that heterozygous deficiency of PPARgamma led to the protection from high-fat diet-induced insulin resistance in an animal model. A Pro12Ala polymorphism has been detected in the human PPARgamma2 gene. Since this amino
K, Hara, T, Okada, K, Tobe, K, Yasuda, Y, Mori, H, Kadowaki, R, Hagura, Y, Akanuma, S, Kimura, C, Ito, T, Kadowaki   +10 more
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Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians

Diabetic Medicine, 2007
AbstractAims  The aim of the study was to investigate the association of serum adiponectin levels with the Pro12Ala polymorphism of the peroxisome proliferator activated receptor‐γ (PPARG) gene in Asian Indians.Methods  We selected 400 diabetic subjects, 200 with the Pro12Pro genotype (100 male and 100 female) and 200 with the Pro12Ala genotype (100 ...
Radha, V, Vimaleswaran, K S, Babu, S, Deepa, R, Anjana, M, Ghosh, S, Majumder, P P, Rao, M R S, Mohan, V   +8 more
openaire   +5 more sources

Quantitative evaluation of PPAR-γ2 Pro12Ala polymorphism with hypertension

Herz, 2017
The peroxisome proliferator-activated receptor γ2 (PPARγ2)Pro12Ala polymorphism has been reported to be associated with hypertension. However, relevant studies have shown inconsistent results.To quantitatively evaluate the relationship between the PPARγ2Pro12Ala polymorphism and hypertension risk, we conducted a meta-analysis based on all available ...
W, Yang, J, Wang, W, Ye, X, Li
openaire   +2 more sources

Interaction Between Pro12Ala Polymorphism of PPARγ2 and Diet on Adiposity Phenotypes

Current Atherosclerosis Reports, 2014
The aim of this report is to perform a systematic review and qualitative synthesis of the literature to address whether, and to what extent, diet modulates the effects of the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 (PPARγ2) on body weight and other measures of adiposity.
LAPICE, EMANUELA, VACCARO, OLGA
openaire   +3 more sources

Association between PPAR-γ2 Pro12Ala polymorphism and obesity: a meta-analysis

Molecular Biology Reports, 2014
The peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene has been reported in the pathogeny of obesity. However, the results have been inconsistent. The purpose of this meta-analysis was to acquire a more accurate assessment of the association between PPAR-γ2 Pro12Ala polymorphism and obesity.
Ying-Shui, Yao, Jie, Li, Yue-Long, Jin, Yan, Chen, Lian-Ping, He   +4 more
openaire   +2 more sources

Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases

Diabetes Research and Clinical Practice, 2004
To clarify the contribution of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene to susceptibility to insulin resistance and related diseases, 505 unrelated Japanese subjects were investigated, including 175 normotensive non-diabetic (NN) subjects, 125 normotensive diabetic (ND) subjects, 102 ...
Mayumi, Horiki, Hiroshi, Ikegami, Tomomi, Fujisawa, Yumiko, Kawabata, Masaya, Ono, Masanori, Nishino, Kazuaki, Shimamoto, Toshio, Ogihara   +7 more
openaire   +2 more sources

No evidence of a role for PPAR?? Pro12Ala polymorphism in endometrial cancer susceptibility

Pharmacogenetics, 2004
Endogenous oestrogens play a crucial role in endometrial cancer pathogenesis, with most endometrial cancer risk factors causing an increase in oestrogens. Adipose tissue, where androgens are converted to oestrogens by the enzyme aromatase, is an important source of endogenous oestrogen production in the postmenopausal woman. The peroxisome proliferator-
Randi A, Paynter, Susan E, Hankinson, Graham A, Colditz, David J, Hunter, Immaculata, De Vivo   +4 more
openaire   +2 more sources

An age-dependent diet-modified effect of the PPARγ Pro12Ala polymorphism in children

Metabolism, 2011
Variation in the peroxisome proliferator-activated receptor γ gene alters the risk for adiposity in adults, with evidence of interaction with diet. We investigated the age-related association between the Pro12Ala variant (rs1801282) and diet in obesity-related traits in children. The Pro12Ala variant was assayed in 2102 young children aged 1 to 6 years
Dedoussis, George V., Manios, Yannis, Kourlaba, Georgia, Kanoni, Stavroula, Lagou, Vasiliki, Butler, Johannah, Papoutsakis, Constantina, Scott, Robert A., Yannakoulia, Mary, Pitsiladis, Yannis, Hirschhorn, Joel N., Lyon, Helen N.   +11 more
openaire   +2 more sources